Zobrazeno 1 - 10
of 2 566
pro vyhledávání: '"γ secretase"'
Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier
Autor:
Laura Fritzen, Katharina Wienken, Lelia Wagner, Magdalena Kurtyka, Katharina Vogel, Jakob Körbelin, Sascha Weggen, Gert Fricker, Claus U. Pietrzik
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-23 (2024)
Abstract Background The most crucial area to focus on when thinking of novel pathways for drug delivery into the CNS is the blood brain barrier (BBB). A number of nanoparticulate formulations have been shown in earlier research to target receptors at
Externí odkaz:
https://doaj.org/article/6959b746fc7b4f43abec3dada8978c0c
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101041- (2024)
The activation of the Notch pathway promotes the occurrence and progression of breast cancer. The Notch signal plays different roles in different molecular subtypes of breast cancer. In estrogen receptor-positive (ER+) breast cancer, the Notch pathwa
Externí odkaz:
https://doaj.org/article/8adbf8e4a83442dab4ae701daa40e8d1
Autor:
Steven S Hou, Yuya Ikegawa, Yeseo Kwon, Natalia Wieckiewicz, Mei CQ Houser, Brianna Lundin, Brian J Bacskai, Oksana Berezovska, Masato Maesako
Publikováno v:
eLife, Vol 13 (2024)
γ-Secretase plays a pivotal role in the central nervous system. Our recent development of genetically encoded Förster resonance energy transfer (FRET)-based biosensors has enabled the spatiotemporal recording of γ-secretase activity on a cell-by-c
Externí odkaz:
https://doaj.org/article/ff11a7dff0964b278922b4ba3c0fa4b1
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102314- (2024)
Adeno-associated virus (AAV) gene therapy for neurological disease has gained traction due to stunning advances in capsid evolution for CNS targeting. With AAV brain delivery now in focus, conventional improvements in viral expression vectors offer a
Externí odkaz:
https://doaj.org/article/364ed6dd98b84ec3a0c82e3411fd7ae9
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10294 (2024)
In the search for Alzheimer’s disease (AD) therapies, most animal models focus on familial AD, which accounts for a small fraction of cases. The majority of AD cases arise from stress factors, such as oxidative stress, leading to neurological chang
Externí odkaz:
https://doaj.org/article/4c54fb4326464178bfd2b59bbca7160d
Autor:
Kévin Muret, Vincent Le Goff, Claire Dandine-Roulland, Claire Hotz, Francette Jean-Louis, Bertrand Boisson, Lilia Mesrob, Florian Sandron, Delphine Daian, Robert Olaso, Edith Le Floch, Vincent Meyer, Pierre Wolkenstein, Jean-Laurent Casanova, Yves Lévy, Eric Bonnet, Jean-François Deleuze, Sophie Hüe
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10374 (2024)
Hidradenitis suppurativa (HS) is a chronic skin disease characterized by painful, recurrent abscesses, nodules, and scarring, primarily in skin folds. The exact causes of HS are multifactorial, involving genetic, hormonal, and environmental factors.
Externí odkaz:
https://doaj.org/article/f1aa4492718146ca81b822bc1aed3e8f
Autor:
Ali Yaghoubi
Publikováno v:
Journal of Kerman University of Medical Sciences, Vol 30, Iss 3, Pp 136-145 (2023)
Background: Alzheimer›s disease (AD) is characterized by excessive deposition of the amyloid-β peptide (Aβ) in the central nervous system and reducing its level is the goal of many medications. This study aimed to investigate the effect of aerobi
Externí odkaz:
https://doaj.org/article/2ce68136c6dc49a49a61b31660afd088
Autor:
Kevin C. Lahey, Christopher Varsanyi, Ziren Wang, Ahmed Aquib, Varsha Gadiyar, Alcina A. Rodrigues, Rachael Pulica, Samuel Desind, Viralkumar Davra, David C. Calianese, Dongfang Liu, Jong-Hyun Cho, Sergei V. Kotenko, Mariana S. De Lorenzo, Raymond B. Birge
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4404 (2024)
Mertk, a type I receptor tyrosine kinase and member of the TAM family of receptors, has important functions in promoting efferocytosis and resolving inflammation under physiological conditions. In recent years, Mertk has also been linked to pathophys
Externí odkaz:
https://doaj.org/article/58f6637deb6f481abb21a79db945bb96
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3322 (2024)
The highly conserved Notch signaling pathway affects embryonic development, neurogenesis, homeostasis, tissue repair, immunity, and numerous other essential processes. Although previous studies have demonstrated the location and function of the core
Externí odkaz:
https://doaj.org/article/1a4de2c980d34eedb425fbde2a7aeaba
Autor:
Jiaxuan Li, Xin Wu, Xin Tan, Shixin Wang, Ruisi Qu, Xiaofeng Wu, Zhouqing Chen, Zhong Wang, Gang Chen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
BackgroundThis meta-analysis evaluates the efficacy and safety of amyloid-β (Aβ) targeted therapies for delaying cognitive deterioration in Alzheimer’s disease (AD).MethodsPubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov were systemat
Externí odkaz:
https://doaj.org/article/b614396effef43078df3520f6bb820c4