Role of β2‐glycoprotein I in the pathogenesis of the antiphospholipid syndrome

Autor: Jing Li, Xiangrui Zhu, Juan Feng

Publikováno v: Rheumatology & Autoimmunity, Vol 3, Iss 3, Pp 131-139 (2023)

Abstract Antiphospholipid syndrome (APS) is typically characterized by increased levels of three classes of antiphospholipid antibodies, namely lupus anticoagulant, anti‐β2‐glycoprotein I (anti‐β2GPI), and anticardiolipin antibodies. β2‐Gl

Externí odkaz: https://doaj.org/article/b2931fb11b894367a54bd6509ccc4024

Structural analyses of β2-glycoprotein I: is there a circular conformation?

Autor: Kumar, Suresh, Wulf, John, II, Basore, Katherine, Pozzi, Nicola

Publikováno v: In Journal of Thrombosis and Haemostasis December 2023 21(12):3511-3521

Epitope of antiphospholipid antibodies retrieved from peptide microarray based on R39‐R43 of β2‐glycoprotein I

Autor: Moghbel, Marc, Roth, Aline, Baptista, Daniela, Miteva, Kapka, Burger, Fabienne, Montecucco, Fabrizio, Vuilleumier, Nicolas, Mach, François, Brandt, Karim J. ^*

Publikováno v: In Research and Practice in Thrombosis and Haemostasis October 2022 6(7)

Identification of thrombosis-related conformational binding epitopes on domain I of β2-glycoprotein I.

Autor: Kim SJ; Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, United States of America; Departments of Physics and Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea., Schneidman-Duhovny D; Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, United States of America; School of Computer Science and Engineering, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., de Groot PG; Department of Functional Coagulation, Synapse Research Institute, Maastricht, the Netherlands; Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, the Netherlands., Urbanus RT; Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, the Netherlands., Carter L; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, United States of America., de Laat-Kremers R; Department of Data Analysis and Artificial Intelligence, Synapse Research Institute, Maastricht, the Netherlands., Weiss TM; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, United States of America., Chan MK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States of America., Sali A; Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, United States of America., Rand JH; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, United States of America., de Laat B; Department of Functional Coagulation, Synapse Research Institute, Maastricht, the Netherlands; Department of Data Analysis and Artificial Intelligence, Synapse Research Institute, Maastricht, the Netherlands. Electronic address: b.delaat@thrombin.com.

Publikováno v: Thrombosis research [Thromb Res] 2024 May; Vol. 237, pp. 145-147. Date of Electronic Publication: 2024 Mar 28.

An allosteric redox switch in domain V of β2-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition

Autor: Kumar, Suresh, Chinnaraj, Mathivanan, Planer, William, Zuo, Xiaobing, Macor, Paolo, Tedesco, Francesco, Pozzi, Nicola

Publikováno v: In Journal of Biological Chemistry August 2021 297(2)