Zobrazeno 1 - 10
of 4 073
pro vyhledávání: '"β-cells"'
Autor:
Haneen Yehya, Alexandra Wells, Michael Majcher, Dhruv Nakhwa, Ryan King, Faruk Senturk, Roshan Padmanabhan, Jan Jensen, Michael A. Bukys
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Background Type 1 diabetes, an autoimmune disorder leading to the destruction of pancreatic β-cells, requires lifelong insulin therapy. Islet transplantation offers a promising solution but faces challenges such as limited availability and
Externí odkaz:
https://doaj.org/article/5de5ed93cc004b8ebe83135ec58b7bd9
Publikováno v:
Медицинская иммунология, Vol 26, Iss 5, Pp 1037-1044 (2024)
Type 2 diabetes mellitus is characterized by a mild inflammatory reaction in the pancreas, which affects the structure and function of the pancreatic islets: the number of β-cells decreases and the number of α-cells increases. The work examined the
Externí odkaz:
https://doaj.org/article/b06ec4a586ec4ff7b8b18613253542c6
Autor:
Fanglin Niu, Wenxuan Liu, Yuanyuan Ren, Ye Tian, Wenzhen Shi, Man Li, Yujia Li, Yuyan Xiong, Lu Qian
Publikováno v:
Journal of Advanced Research, Vol 62, Iss , Pp 71-89 (2024)
Background: Diabetes Mellitus (DM), a chronic metabolic disease characterized by elevated blood glucose, is caused by various degrees of insulin resistance and dysfunctional insulin secretion, resulting in hyperglycemia. The loss and failure of funct
Externí odkaz:
https://doaj.org/article/24763a20252f4ad0b78b5708187e4a82
Autor:
Elisa Zanfrini, Manuj Bandral, Luka Jarc, Maria Alejandra Ramirez-Torres, Daniela Pezzolla, Vida Kufrin, Eva Rodriguez-Aznar, Ana Karen Mojica Avila, Christian Cohrs, Stephan Speier, Katrin Neumann, Anthony Gavalas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The significant advances in the differentiation of human pluripotent stem (hPS) cells into pancreatic endocrine cells, including functional β-cells, have been based on a detailed understanding of the underlying developmental mechanisms. How
Externí odkaz:
https://doaj.org/article/29312b1f86b841f09af33ee6d30fc804
Autor:
Emmanuel Kokori, Gbolahan Olatunji, Ikponmwosa Jude Ogieuhi, John Ehi Aboje, Doyin Olatunji, Sikiru Ademola Aremu, Stephen Chukwuemeka Igwe, Abdulrahmon Moradeyo, Yusuf Ismaila Ajayi, Nicholas Aderinto
Publikováno v:
Clinical Diabetes and Endocrinology, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract This review explores the immunomodulatory potential of Teplizumab and its impact on pancreatic β-cell function in T1D. Characterized by the autoimmune destruction of insulin-producing beta cells, T1D’s management involves maintaining glyc
Externí odkaz:
https://doaj.org/article/9115a43a5147473cbec01891fc6a9e78
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Glucocorticoids (GCs) are known to stimulate pancreatic beta (β)-cell apoptosis via several mechanisms, including oxidative stress. Our previous study suggested an increase in dexamethasone-induced pancreatic β-cell apoptosis via a reducti
Externí odkaz:
https://doaj.org/article/65d6afc4ecc1462aac3cc1992bb61a72
Autor:
Xu Jia, Danting Mao, Jianwei Guo, Jiangyu Ke, Yanlin Zhu, Xiaoyang Zhao, Ziren Luo, Xinghai Liu, Rui Tang, Ruihan Hou, Haitao Lan, Qian zheng
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Long-term exposure to hyperglycemic conditions leads to β-cell dysfunction, particularly mitochondrial dysfunction, and inflammatory and oxidative stress responses, which are considered the primary causes of β-cell death and the hallmarks
Externí odkaz:
https://doaj.org/article/0a7e093681f9453e8c355ffd13e3da01
Autor:
Esmaeel Ghasemi Gojani, Sweta Rai, Farzaneh Norouzkhani, Salma Shujat, Bo Wang, Dongping Li, Olga Kovalchuk, Igor Kovalchuk
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7621-7667 (2024)
The β-cells within the pancreas play a pivotal role in insulin production and secretion, responding to fluctuations in blood glucose levels. However, factors like obesity, dietary habits, and prolonged insulin resistance can compromise β-cell funct
Externí odkaz:
https://doaj.org/article/e7c55875d9b1454db99f789a8dec282f
Autor:
Kukkala Kiran Kumar, Elhadi Husein Aburawi, Milos Ljubisavljevic, Melvin Khee Shing Leow, Xu Feng, Suraiya Anjum Ansari, Bright Starling Emerald
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-31 (2024)
Abstract Diabetes mellitus is a chronic disease that impairs metabolism, and its prevalence has reached an epidemic proportion globally. Most people affected are with type 2 diabetes mellitus (T2DM), which is caused by a decline in the numbers or fun
Externí odkaz:
https://doaj.org/article/0bc565514e6c413996838412b83b87a1
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 6, Pp 684-692 (2024)
ABSTRACT Aims The aim of this study was to better understand how the chemotherapy drug doxorubicin contributes to the development of β‐cell dysfunction and to explore its relationship with mitochondrial aldehyde dehydrogenase‐2 (ALDH2). Material
Externí odkaz:
https://doaj.org/article/19eb8ed8b1574309887ca802bf57cd69