Zobrazeno 1 - 10
of 388
pro vyhledávání: '"β-cell mass"'
Autor:
Ikumi Shigesawa, Akinobu Nakamura, Yuki Yamauchi, Shinichiro Kawata, Asuka Miyazaki, Hiroshi Nomoto, Hiraku Kameda, Yasuo Terauchi, Tatsuya Atsumi
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 12, Pp 1732-1742 (2024)
ABSTRACT Aims/Introduction We previously showed that glucokinase haploinsufficiency improves the glucose tolerance of db/db mice by preserving pancreatic β‐cell mass and function. In the present study, we aimed to determine the effects of glucokin
Externí odkaz:
https://doaj.org/article/bba67f7c420a40d49d04e245e2831cca
Autor:
Francieli Caroline de Ramos, Robson Barth, Marcos Rizzon Santos, Milena dos Santos Almeida, Sandra Mara Ferreira, Alex Rafacho, Antônio Carlos Boschero, Gustavo Jorge dos Santos
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
AimsThis study investigates the role of Hepatocyte Nuclear Factor 4α (HNF4α) in the adaptation of pancreatic β-cells to an HFD-induced obesogenic environment, focusing on β cell mass expansion and metabolic adaptations.Main methodsWe utilized an
Externí odkaz:
https://doaj.org/article/4211cda4aaec48ddb2a189f0ed2242da
Autor:
Quiana C. Wilkerson-Vidal, Moses A. David, James Gerard Wolfsberger, Madushika M. Wimalarathne, Evann Fowler, John R. Diaz, Alexis Fink, Elijah S. Sterkel, Ian Ross, Bernhard Vogler, Sharifa T. Love-Rutledge
Publikováno v:
Journal of Molecular Pathology, Vol 5, Iss 3, Pp 276-291 (2024)
Characterizing changes in beta cell function during prolonged hyperinsulinemia and dietary stress is important to study to prevent diseases like metabolic dysfunction-associated steatotic liver disease and insulin resistance. This research investigat
Externí odkaz:
https://doaj.org/article/a656272b4e274117a462007e22eac689
Autor:
Takaaki Murakami, Toshihiro Nakamura, Hiroyuki Fujimoto, Junji Fujikura, Yoichi Shimizu, Kanae K. Miyake, Daisuke Otani, Kentaro Sakaki, Sakura Kiyobayashi, Takayuki Anazawa, Yuji Nakamoto, Nobuya Inagaki
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 10, Pp 1187-1191 (2023)
ABSTRACT It is crucial to develop practical and noninvasive methods to assess the functional beta‐cell mass in a donor pancreas, in which monitoring and precise evaluation is challenging. A patient with type 1 diabetes underwent noninvasive imaging
Externí odkaz:
https://doaj.org/article/36def31fe724486c943ffe2dd1442a7b
Akademický článek
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Akademický článek
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Autor:
Masato Kohata, Junta Imai, Tomohito Izumi, Junpei Yamamoto, Yohei Kawana, Akira Endo, Hiroto Sugawara, Junro Seike, Haremaru Kubo, Hiroshi Komamura, Toshihiro Sato, Shinichiro Hosaka, Yuichiro Munakata, Yoichiro Asai, Shinjiro Kodama, Kei Takahashi, Keizo Kaneko, Hideki Katagiri
Publikováno v:
Journal of Diabetes Investigation, Vol 13, Iss 10, Pp 1666-1676 (2022)
ABSTRACT Aims/Introduction Whether basal β‐cell proliferation during adulthood is involved in maintaining sufficient β‐cell mass, and if so, the molecular mechanism(s) underlying basal β‐cell proliferation remain unclear. FoxM1 is a critical
Externí odkaz:
https://doaj.org/article/d05dbe7f5379427983242b019fd55228
Autor:
Yukiko K. Kaneko, Yuki Tara, Stella Amarachi Ihim, Moe Yamamoto, Megumi Kaji, Tomohisa Ishikawa
Publikováno v:
Phytomedicine Plus, Vol 2, Iss 4, Pp 100367- (2022)
Background: Nobiletin, a polymethoxy flavone contained in the peel of Citrus reticulata, has been known to have health benefits especially those related to improvement of type 2 diabetes. Our previous in vitro study demonstrated the insulinotropic an
Externí odkaz:
https://doaj.org/article/1f45d57433f343509be7c2f6f45b2511
Akademický článek
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Autor:
Kazuhisa Tsuchida, Akinobu Nakamura, Hideaki Miyoshi, Kelaier Yang, Yuki Yamauchi, Shinichiro Kawata, Kazuno Omori, Kiyohiko Takahashi, Naoyuki Kitao, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, Yusuke Seino, Yasuo Terauchi, Tatsuya Atsumi
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 9, Pp 1545-1554 (2021)
Abstract Aims/Introduction We aimed to determine whether glucokinase is required for β‐cell mass expansion induced by high‐starch diet (HSTD)‐feeding, as has been shown in its high‐fat diet‐induced expansion. Materials and Methods Eight‐
Externí odkaz:
https://doaj.org/article/4a95baf82e6a47f19180c040641d7e6b