Zobrazeno 1 - 10
of 162
pro vyhledávání: '"β-amyloid plaques"'
Autor:
Ruiyi Zhou, Lihong Zhu, Zhaohao Zeng, Rixin Luo, Jiawei Zhang, Rui Guo, Lei Zhang, Qunying Zhang, Wei Bi
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 3, Pp n/a-n/a (2022)
Abstract Alzheimer's disease (AD) is an aging‐related neurodegenerative disease. The main pathological features of AD are β‐amyloid protein (Aβ) deposition and tau protein hyperphosphorylation. Currently, there are no effective drugs for the et
Externí odkaz:
https://doaj.org/article/c25f557b965c41c2be4c96704f0e318c
Autor:
Seyed Behnamedin Jameie, Abbas Pirasteh, Ali Naseri, Melika Sadat Jameie, Mona Farhadi, Javad Fahanik Babaee, Leila Elyasi
Publikováno v:
Basic and Clinical Neuroscience, Vol 12, Iss 3, Pp 383-394 (2021)
Introduction: The increasing cases of Alzheimer Disease (AD) has caused numerous problems. The risk of developing AD increases in menopausal women, too. Apigenin and β-estradiol are effective antioxidant and neuroprotective agents. We conducted the
Externí odkaz:
https://doaj.org/article/aa244086d03d4aa1b05cbeed040ed19c
Autor:
Antonietta Arminio, Tommaso Prioreschi
Publikováno v:
Journal of Biomedical Practitioners, Vol 6, Iss 1 (2022)
INTRODUCTION The development of PET radiopharmaceuticals suitable for the identification and in vivo quantification of β Amyloid plaques has been the focus of intense research, representing a useful means for the non-invasive detection of β Amyl
Externí odkaz:
https://doaj.org/article/a620e6ec760242b2a6d37e221cce1330
Autor:
Joanna E. Pankiewicz, Jenny R. Diaz, Mitchell Martá-Ariza, Anita M. Lizińczyk, Leor A. Franco, Martin J. Sadowski
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-22 (2020)
Abstract Background Disruption of β-amyloid (Aβ) homeostasis is the initial culprit in Alzheimer’s disease (AD) pathogenesis. Astrocytes respond to emerging Aβ plaques by altering their phenotype and function, yet molecular mechanisms governing
Externí odkaz:
https://doaj.org/article/48f180f5016e432d939bf20509db2b33
Autor:
Thrisha T. Reddy, Michael H. Iguban, Lusine L. Melkonyan, Jasmine Shergill, Christopher Liang, Jogeshwar Mukherjee
Publikováno v:
Molecules, Vol 28, Iss 2, p 865 (2023)
Radioiodinated imaging agents for Aβ amyloid plaque imaging in Alzheimer’s disease (AD) patients have not been actively pursued. Our previous studies employed the “diaza” derivatives [11C]TAZA and [18F]flotaza in order to develop successful po
Externí odkaz:
https://doaj.org/article/3625f45b454c460c97e01990a4c47db8
Publikováno v:
Molecules, Vol 27, Iss 14, p 4552 (2022)
Several fluorine-18-labeled PET β-amyloid (Aβ) plaque radiotracers for Alzheimer’s disease (AD) are in clinical use. However, no radioiodinated imaging agent for Aβ plaques has been successfully moved forward for either single-photon emission co
Externí odkaz:
https://doaj.org/article/be06e3b27ae74165a6ee67bb0b870c92
Publikováno v:
Marine Drugs, Vol 20, Iss 4, p 253 (2022)
This paper examined the toxins naturally produced by marine dinoflagellates and their effects on increases in β-amyloid plaques along with tau protein hyperphosphorylation, both major drivers of Alzheimer’s disease (AD). This approach is in line w
Externí odkaz:
https://doaj.org/article/ec0c832958144e88a03bcc3566c18d4c
Autor:
Jorge Berlanga-Acosta, Gerardo Guillén-Nieto, Nadia Rodríguez-Rodríguez, Maria Luisa Bringas-Vega, Diana García-del-Barco-Herrera, Jorge O. Berlanga-Saez, Ariana García-Ojalvo, Mitchell Joseph Valdés-Sosa, Pedro A. Valdés-Sosa
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Insulin plays a major neuroprotective and trophic function for cerebral cell population, thus countering apoptosis, beta-amyloid toxicity, and oxidative stress; favoring neuronal survival; and enhancing memory and learning processes. Insulin resistan
Externí odkaz:
https://doaj.org/article/0599b7aeff384cd1ab30f22a55016797
Autor:
Adele Woodhouse, Carmen Maria Fernandez-Martos, Rachel Alice Kathryn Atkinson, Kelsey Anne Hanson, Jessica Marie Collins, Aidan Ryan O’Mara, Nico Terblanche, Marcus Welby Skinner, James Clement Vickers, Anna Elizabeth King
Publikováno v:
BMC Anesthesiology, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background There is increasing interest in whether anesthetic agents affect the risk or progression of Alzheimer’s disease (AD). To mitigate many of the methodological issues encountered in human retrospective cohort studies we have used a
Externí odkaz:
https://doaj.org/article/9d31865b280e468a93007bf83d1b1f0f
Autor:
Elena Sánchez-López, Miren Ettcheto, Maria Antonia Egea, Marta Espina, Amanda Cano, Ana Cristina Calpena, Antoni Camins, Nuria Carmona, Amélia M. Silva, Eliana B. Souto, Maria Luisa García
Publikováno v:
Journal of Nanobiotechnology, Vol 16, Iss 1, Pp 1-16 (2018)
Abstract Background Memantine, drug approved for moderate to severe Alzheimer’s disease, has not shown to be fully effective. In order to solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could be a suitable solution to increase drug’
Externí odkaz:
https://doaj.org/article/09b836cd23f64c6aa9ac7db605e7ce8a