Zobrazeno 1 - 10
of 8 627
pro vyhledávání: '"β cell"'
Autor:
Ikumi Shigesawa, Akinobu Nakamura, Yuki Yamauchi, Shinichiro Kawata, Asuka Miyazaki, Hiroshi Nomoto, Hiraku Kameda, Yasuo Terauchi, Tatsuya Atsumi
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 12, Pp 1732-1742 (2024)
ABSTRACT Aims/Introduction We previously showed that glucokinase haploinsufficiency improves the glucose tolerance of db/db mice by preserving pancreatic β‐cell mass and function. In the present study, we aimed to determine the effects of glucokin
Externí odkaz:
https://doaj.org/article/bba67f7c420a40d49d04e245e2831cca
Autor:
Naeimeh Rezaei, Kianoush Dormiani, Abbas Kiani-Esfahani, Somayeh Mirdamadian, Mohsen Rahmani, Farnoosh Jafarpour, Mohammad Hossein Nasr-Esfahani
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract PDX1 is a crucial transcription factor in pancreas development and mature β-cell function. However, the regulation of PDX1 expression in larger animals mirroring human pancreas morphogenesis and endocrine maturation remains poorly understoo
Externí odkaz:
https://doaj.org/article/f25a74f0e1bc4f98b22f5064fe1b5d33
Autor:
Yanping SUN, Xueyu ZHANG, Ye TIAN, Meng CHEN, Shanshan DOU, Shuo LI, Huimin ZHANG, Huijia SONG, Yanfang ZHAO, Zibin GAO
Publikováno v:
Journal of Hebei University of Science and Technology, Vol 45, Iss 5, Pp 479-486 (2024)
In order to detemine the anti-diabetic effect and potential mechanism of a novel soluble epoxide hydrolas inhibitor (A34) on diabetic mice. Type 1 diabetes mellitus (T1DM) mice were induced by streptozotocin (50 mg/(kg·d) for 5 days, ip.)and the hyp
Externí odkaz:
https://doaj.org/article/405977c5828e46d7bf5727b36cf563d5
Autor:
Li FXZ, Xu F, Li CC, Lei LM, Shan SK, Zheng MH, Lin X, Guo B, Tang KX, Duan JY, Wu YY, Cao YC, Liu JJ, Yuan LQ
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 10077-10095 (2024)
Fu-Xing-Zi Li,1 Feng Xu,1 Chang-Chun Li,1 Li-Min Lei,1 Su-Kang Shan,1 Ming-Hui Zheng,1 Xiao Lin,2 Bei Guo,1 Ke-Xin Tang,1 Jia-Yue Duan,1 Yun-Yun Wu,1 Ye-Chi Cao,1 Jun-Jie Liu,3 Ling-Qing Yuan1 1Department of Metabolism and Endocrinology, National Cli
Externí odkaz:
https://doaj.org/article/f19967b0c8104e73a20c78d39621290b
Autor:
Francieli Caroline de Ramos, Robson Barth, Marcos Rizzon Santos, Milena dos Santos Almeida, Sandra Mara Ferreira, Alex Rafacho, Antônio Carlos Boschero, Gustavo Jorge dos Santos
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
AimsThis study investigates the role of Hepatocyte Nuclear Factor 4α (HNF4α) in the adaptation of pancreatic β-cells to an HFD-induced obesogenic environment, focusing on β cell mass expansion and metabolic adaptations.Main methodsWe utilized an
Externí odkaz:
https://doaj.org/article/4211cda4aaec48ddb2a189f0ed2242da
Publikováno v:
Медицинская иммунология, Vol 26, Iss 5, Pp 1037-1044 (2024)
Type 2 diabetes mellitus is characterized by a mild inflammatory reaction in the pancreas, which affects the structure and function of the pancreatic islets: the number of β-cells decreases and the number of α-cells increases. The work examined the
Externí odkaz:
https://doaj.org/article/b06ec4a586ec4ff7b8b18613253542c6
Autor:
Xia L, Yang M, Zang N, Song J, Chen J, Hu H, Wang K, Xiang Y, Yang J, Wang L, Zou Y, Lv X, Hou X, Chen L
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 9575-9596 (2024)
Longqing Xia,1 Mengmeng Yang,1 Nan Zang,1– 4 Jia Song,1– 4 Jun Chen,1– 4 Huiqing Hu,1 Kewei Wang,1 Yingyue Xiang,1 Jingwen Yang,1 Liming Wang,1 Ying Zou,1 Xiaoyu Lv,1 Xinguo Hou,1– 4 Li Chen1– 4 1Department of Endocrinology, Qilu Hospital o
Externí odkaz:
https://doaj.org/article/124f2a6845cc489787ba6c86d45b2f90
Autor:
Satomi Minato-Inokawa, Ayaka Tsuboi-Kaji, Mari Honda, Mika Takeuchi, Kaori Kitaoka, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract The present study investigated the associations of serum gamma-glutamyl transferase (GGT), a marker of fatty liver and oxidative stress, and ALT/AST, a marker of fatty liver, with percentage trunk fat and postload glucose, insulin resistance
Externí odkaz:
https://doaj.org/article/e1770139da1e434aaa6fad11e8e35231
Autor:
Satomi Minato-Inokawa, Mari Honda, Ayaka Tsuboi-Kaji, Mika Takeuchi, Kaori Kitaoka, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract The relationship of adipose tissue insulin resistance (AT-IR, a product of fasting insulin and free fatty acids) and homeostasis-model assessment-insulin resistance (HOMA-IR) to β-cell function was studied cross-sectionally in the setting o
Externí odkaz:
https://doaj.org/article/bf5db172db8a4c4ca671437364e00b00
Autor:
Quiana C. Wilkerson-Vidal, Moses A. David, James Gerard Wolfsberger, Madushika M. Wimalarathne, Evann Fowler, John R. Diaz, Alexis Fink, Elijah S. Sterkel, Ian Ross, Bernhard Vogler, Sharifa T. Love-Rutledge
Publikováno v:
Journal of Molecular Pathology, Vol 5, Iss 3, Pp 276-291 (2024)
Characterizing changes in beta cell function during prolonged hyperinsulinemia and dietary stress is important to study to prevent diseases like metabolic dysfunction-associated steatotic liver disease and insulin resistance. This research investigat
Externí odkaz:
https://doaj.org/article/a656272b4e274117a462007e22eac689