Zobrazeno 1 - 10
of 10 214
pro vyhledávání: '"β amyloid"'
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-48 (2024)
Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder, characterized pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and intracellular accumulation of hyperphosphorylated tau (pTau) as ne
Externí odkaz:
https://doaj.org/article/7e1c77e3b8ed40e2ae273155ed209e53
Autor:
Oliwia Koszła, Przemysław Sołek
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract The primary challenge in today’s world of neuroscience is the search for new therapeutic possibilities for neurodegenerative disease. Central to these disorders lies among other factors, the aberrant folding, aggregation, and accumulation
Externí odkaz:
https://doaj.org/article/decd79ac91bf42d9af4d437c2b88473e
Autor:
Ji-Won Lee, Kaito Mizuno, Haruhisa Watanabe, In-Hee Lee, Takuya Tsumita, Kyoko Hida, Yasutaka Yawaka, Yoshimasa Kitagawa, Akira Hasebe, Tadahiro Iimura, Sek Won Kong
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Multinucleated microglia have been observed in contexts associated with infection, inflammation, and aging. Though commonly linked to pathological conditions, the larger cell size of multinucleated microglia might enhance their phagocytic fu
Externí odkaz:
https://doaj.org/article/42390726e32e40f7b382cf7f7dcc8d93
Publikováno v:
Journal of Taibah University Medical Sciences, Vol 19, Iss 3, Pp 549-565 (2024)
الملخص: تطور مرض ألزهايمر كنتيجة لتكوين علامتين رئيسيتين، والتي تتضمن تشكيل طفيليات البيتا-أميلويد خارج الخلو وفرط فسفرة بروتين الـ تاو
Externí odkaz:
https://doaj.org/article/7285c341bed94ce79ecdb3672abd03de
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background Recent reports suggest that amyloid beta (Aβ) peptides can exhibit prion-like pathogenic properties. Transmission of Aβ peptide and the development of associated pathologies after surgeries with contaminated instruments and intr
Externí odkaz:
https://doaj.org/article/138af1cc6e0145c7ac61284247af3f6e
Autor:
Iram Iqbal, Fatima Saqib, Zobia Mubarak, Muhammad Farhaj Latif, Muqeet Wahid, Bushra Nasir, Hamna Shahzad, Javad Sharifi-Rad, Mohammad S. Mubarak
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-20 (2024)
Abstract Alzheimer's disease (AD) is a diverse disease with a complex pathophysiology. The presence of extracellular β-amyloid deposition as neuritic plaques and intracellular accumulation of hyper-phosphorylated tau as neurofibrillary tangles remai
Externí odkaz:
https://doaj.org/article/f02291430fa24c19b79083fa28bcc496
Autor:
Emily Nicole Holy, Elizabeth Li, Anjan Bhattarai, Evan Fletcher, Evelyn R. Alfaro, Danielle J. Harvey, Benjamin A. Spencer, Simon R. Cherry, Charles S. DeCarli, Audrey P. Fan
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Background Kinetic modeling of 18F-florbetaben provides important quantification of brain amyloid deposition in research and clinical settings but its use is limited by the requirement of arterial blood data for quantitative PET. The total-b
Externí odkaz:
https://doaj.org/article/3ececbf692bd45db9c93eea02bbbfaa9
Autor:
Meiqi Wu, Chao Ren, Chenhui Mao, Liling Dong, Bo Li, Xueqian Yang, Zhenghai Huang, Haiqiong Zhang, Yuying Li, Mengshi Yan, Qi Ge, Runze Wu, Feng Feng, Mengchao Cui, Jing Gao, Li Huo
Publikováno v:
NeuroImage, Vol 298, Iss , Pp 120779- (2024)
[18F]-Florbetazine ([18F]-92) is a selective PET tracer for β-amyloid (Aβ) depositions with a novel diaryl-azine scaffold to reduce lipophilicity and to achieve higher gray-to-white matter contrast. We aimed to assess its diagnostic value in Alzhei
Externí odkaz:
https://doaj.org/article/5d31dd3711724024be285c142a7fafe2
Publikováno v:
Experimental Gerontology, Vol 194, Iss , Pp 112514- (2024)
Mitochondrial dysfunction is a prominent hallmark of Alzheimer's disease (AD). The transcriptional coactivator PPARγ coactivator 1 (PGC-1a) has been identified as a key regulator of mitochondrial biogenesis and function. However, the precise structu
Externí odkaz:
https://doaj.org/article/d9cea98039914a2d951166fe1df3d2ee
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
In Alzheimer’s Disease (AD), amyloidogenic proteins (APs), such as β-amyloid (Aβ) and tau, may act as alarmins/damage-associated molecular patterns (DAMPs) to stimulate neuroinflammation and cell death. Indeed, recent evidence suggests that brain
Externí odkaz:
https://doaj.org/article/dd04d25fb9a746929da286ac594a8102