Zobrazeno 1 - 10
of 10 289
pro vyhledávání: '"β − amyloid"'
Autor:
Alexandra V. Sentyabreva, Olyesya A. Vasyukova, Yana A. Zorkina, Alisa V. Andryuschenko, Georgy P. Kostyuk, Irina Z. Eremina, Anna M. Kosyreva
Publikováno v:
RUDN Journal of Medicine, Vol 28, Iss 4, Pp 488-498 (2024)
Relevance. Alzheimer’s disease (AD) is the most cause of disability and dementia, which is the 7th leading cause of death worldwide. Diagnosis of AD includes detection of amyloid plaques and hyperphosphorylated tau protein (pTau) in the brain. Howe
Externí odkaz:
https://doaj.org/article/0f0c678ed60d4e1fbb2e0db4defb0f3b
Autor:
Pranav Preman, Daan Moechars, Emre Fertan, Leen Wolfs, Lutgarde Serneels, Disha Shah, Jochen Lamote, Suresh Poovathingal, An Snellinx, Renzo Mancuso, Sriram Balusu, David Klenerman, Amaia M Arranz, Mark Fiers, Bart De Strooper
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 12, Pp 3113-3141 (2024)
Abstract The major genetic risk factor for Alzheimer’s disease (AD), APOE4, accelerates beta-amyloid (Aβ) plaque formation, but whether this is caused by APOE expressed in microglia or astrocytes is debated. We express here the human APOE isoforms
Externí odkaz:
https://doaj.org/article/8623492f8242414195b2b4f5b3e4002e
Autor:
Hadir E. AlQot, Rebecca Jane Rylett
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Alzheimer’s disease (AD) is characterized by amyloidosis, neuroinflammation, cholinergic dysfunction and cognitive impairment. In AD, the cholinergic neuronal marker choline acetyltransferase (ChAT) is reduced and the primate-specific nucl
Externí odkaz:
https://doaj.org/article/6a1c4460b13e454b83e19b5852d0dedd
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 7993-8008 (2024)
Chi-Chen Huang,1 Sheng-Feng Tsai,2,3 Shu-Cheng Liu,4 Mei-Chen Yeh,5 Hao-Chang Hung,5 Chu-Wan Lee,6 Ching-Li Cheng,6 Pei-Ling Hsu,7– 9 Yu-Min Kuo2,3 1Division of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College o
Externí odkaz:
https://doaj.org/article/dd07563a26044af284d5fcdb7e35f483
Publikováno v:
Journal of Innate Immunity, Vol 16, Iss 1, Pp 501-512 (2024)
Introduction: Osteoarthritis (OA) is a prevalent chronic joint disorder. It is characterized by an immune response that maintains a low level of inflammation throughout its progression. During OA, cartilage degradation leads to the release of damage-
Externí odkaz:
https://doaj.org/article/152dd123181c4a98bbc3d73f8adaa8d5
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disease that causes cognitive dysfunction in older adults. One of the AD pathological factors, β-Amyloid (Aβ), triggers inflammatory responses and phagocytosis of microglia. C-ty
Externí odkaz:
https://doaj.org/article/8fec39495d024e938bed4c6fc44d369b
Autor:
Richa Arya, Smita Jain, Sarvesh Paliwal, Kirtika Madan, Swapnil Sharma, Achal Mishra, Prashant Tiwari, Sunil Kumar Kadiri
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 9, Pp 369-381 (2024)
Alzheimer’s disease is a neurological disorder marked by the accumulation of amyloid beta (Aβ) aggregates, resulting from mutations in the amyloid precursor protein. The enzyme β-secretase, also known as β-site amyloid precursor protein cleaving
Externí odkaz:
https://doaj.org/article/951eb488d02145528b4cd5f5f3dabbf5
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-48 (2024)
Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder, characterized pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and intracellular accumulation of hyperphosphorylated tau (pTau) as ne
Externí odkaz:
https://doaj.org/article/7e1c77e3b8ed40e2ae273155ed209e53
Autor:
Oliwia Koszła, Przemysław Sołek
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract The primary challenge in today’s world of neuroscience is the search for new therapeutic possibilities for neurodegenerative disease. Central to these disorders lies among other factors, the aberrant folding, aggregation, and accumulation
Externí odkaz:
https://doaj.org/article/decd79ac91bf42d9af4d437c2b88473e
Autor:
Ji-Won Lee, Kaito Mizuno, Haruhisa Watanabe, In-Hee Lee, Takuya Tsumita, Kyoko Hida, Yasutaka Yawaka, Yoshimasa Kitagawa, Akira Hasebe, Tadahiro Iimura, Sek Won Kong
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Multinucleated microglia have been observed in contexts associated with infection, inflammation, and aging. Though commonly linked to pathological conditions, the larger cell size of multinucleated microglia might enhance their phagocytic fu
Externí odkaz:
https://doaj.org/article/42390726e32e40f7b382cf7f7dcc8d93