Zobrazeno 1 - 10
of 4 623
pro vyhledávání: '"β‐Lactams"'
Autor:
Grabrijan Katarina, Benedik Nika Strašek, Krajnc Alen, Bozovičar Krištof, Knez Damijan, Proj Matic, Zdovc Irena, Sosič Izidor, Contreras-Martel Carlos, Dessen Andréa, Rambaher Martina Hrast, Gobec Stanislav
Publikováno v:
Acta Pharmaceutica, Vol 74, Iss 3, Pp 423-440 (2024)
In the final phases of bacterial cell wall synthesis, penicillin-binding proteins (PBPs) catalyze the cross-linking of peptidoglycan. For many decades, effective and non-toxic β-lactam antibiotics have been successfully used as mimetics of the d-Ala
Externí odkaz:
https://doaj.org/article/0a44049b698a43a69a46f899c02c3c33
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1894-1899 (2024)
In this work, we report an efficient approach to 2-oxoazetidine-3-carboxylic acid derivatives based on a thermally promoted Wolff rearrangement of diazotetramic acids in the presence of nucleophiles. The method allows easy variation of the substituen
Externí odkaz:
https://doaj.org/article/7d51cedb72db4a7eb88259a2ac5f95f7
Autor:
Baolei Jia, Ju Hye Baek, Jae Kyeong Lee, Ying Sun, Kyung Hyun Kim, Ji Young Jung, Che Ok Jeon
Publikováno v:
Advanced Science, Vol 11, Iss 46, Pp n/a-n/a (2024)
Abstract β‐lactams, the most common antibiotics globally, have resistance primarily determined by β‐lactamases. Human microbiota and β‐lactams influence mutually; however, β‐lactamase variety and abundance in the human microbiome remain p
Externí odkaz:
https://doaj.org/article/6807c04cab8a4587983b4d99222a6f5a
Autor:
Diletta Mazzantini, Mariacristina Massimino, Marco Calvigioni, Virginia Rossi, Francesco Celandroni, Antonella Lupetti, Giovanna Batoni, Emilia Ghelardi
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionAntibiotic resistance represents one of the most significant threats to public health in the 21st century. Polyphenols, natural molecules with antibacterial activity produced by plants, are being considered as alternative antimicrobial st
Externí odkaz:
https://doaj.org/article/004b449279ba4af29f6c6d82a4d3115e
Publikováno v:
Foods, Vol 13, Iss 19, p 3201 (2024)
The emergence of inactivation enzyme-encoding genes tet(X), blaEBR, and estT challenges the effectiveness of tetracyclines, β-lactams, and macrolides. This study aims to explore the concurrence and polymorphism of their variants in Empedobacter sp.
Externí odkaz:
https://doaj.org/article/4c193ffcd0fe41968b8f284b430f6e3e
Autor:
Khalid M. Dousa, Eunjeong Shin, Sebastian G. Kurz, Mark Plummer, Mary Nantongo, Christopher R. Bethel, Magdalena A. Taracila, David C. Nguyen, Barry N. Kreiswith, Charles L. Daley, Kenneth E. Remy, Steven M. Holland, Robert A. Bonomo
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Mycobacterium abscessus (Mab) affects patients with immunosuppression or underlying structural lung diseases such as cystic fibrosis (CF). Additionally, Mab poses clinical challenges due to its resistance to multiple antibiotics. Herein, we
Externí odkaz:
https://doaj.org/article/fa9a808cd6454120a8ebb14d852179cd
Publikováno v:
Iranian Journal of Microbiology, Vol 16, Iss 2 (2024)
Background and Objectives: Multi-drug-resistant pathogens pose a significant threat as they can rapidly spread, leading to severe healthcare-associated invasive infections. In developing countries, diarrheagenic Escherichia coli (DEC) is a major bact
Externí odkaz:
https://doaj.org/article/be12d3506a6144d99060f9574f056fb8
Autor:
João Gonçalves Pereira, Joana Fernandes, Tânia Mendes, Filipe André Gonzalez, Susana M. Fernandes
Publikováno v:
Antibiotics, Vol 13, Iss 9, p 853 (2024)
Antimicrobial dosing can be a complex challenge. Although a solid rationale exists for a link between antibiotic exposure and outcome, conflicting data suggest a poor correlation between pharmacokinetic/pharmacodynamic targets and infection control.
Externí odkaz:
https://doaj.org/article/276e5f49d3164e529912c390e365738a
Publikováno v:
Antibiotics, Vol 13, Iss 8, p 783 (2024)
In recent years, bacterial resistance to conventional antibiotics has become a major concern in the medical field. The global misuse of antibiotics in clinics, personal use, and agriculture has accelerated this resistance, making infections increasin
Externí odkaz:
https://doaj.org/article/c26ea57cc51f4c878209cfa234ff0f01
Autor:
Mohammed S. Alasmari, Fawaz Alasmari, Shakir D. Alsharari, Abdullah F. Alasmari, Nemat Ali, Syed Rizwan Ahamad, Abdullah M. Alghamdi, Aban A. Kadi, Alaa M. Hammad, Yousif S. Mohamed Ali, Wayne E. Childers, Magid Abou-Gharbia, Youssef Sari
Publikováno v:
Toxics, Vol 12, Iss 8, p 604 (2024)
Opioid-related deaths are attributed to overdoses, and fentanyl overdose has been on the rise in many parts of the world, including the USA. Glutamate transporter 1 (GLT-1) has been identified as a therapeutic target in several preclinical models of
Externí odkaz:
https://doaj.org/article/f00966e2d097485eb570a59f9dccf2b0