Výsledky vyhledávání - "αv integrins"

Akademický článek

The effect of divalent metal cations on the αv integrin binding site is ligand and integrin specific

Publikováno v: Biomedicine & Pharmacotherapy, Vol 110, Iss , Pp 362-370 (2019)

The binding of orthosteric ligands to integrins requires the presence of divalent metal cations bound to metal ion-binding sites located in the I domains of the integrin α and β subunits. In this study the influence of the type and concentration of

Externí odkaz: https://doaj.org/article/1942c4a1b4574db9ac65e75985ad1f78

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Emerging therapeutic opportunities for integrin inhibitors

Autor: James A. Roper, Simon J. F. Macdonald, Robert J. Slack, Richard J. D. Hatley, R. G. Jenkins

Publikováno v: Nature Reviews. Drug Discovery

Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLβ2 for cardiovascular diseases, inflammatory bowel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec92279a6333adbcbbb9fa28d8e0c4b8
https://doi.org/10.1038/s41573-021-00284-4

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Iridium-catalysed C–H borylation of β-aryl-aminopropionic acids

Autor: Henry Robinson, Simon J. F. Macdonald, Klemensas Simelis, Andrew Nortcliffe, Joe Stillibrand

Publikováno v: Organic & Biomolecular Chemistry. 18:6696-6701

Iridium-catalysed catalytic, regioselective C–H borylation of β-aryl-aminopropionic acid derivatives gives access to 3,5-functionalised protected β-aryl-aminopropionic acid boronates. The synthetic versatility of these new boronates is demonstrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::376e265aa5dd5fadc2188b600e03164b
https://doi.org/10.1039/d0ob01495h

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Pivotal role for α V integrins in sustained Tfh support of the germinal center response for long-lived plasma cell generation

Autor: Deborah J. Fowell, Angela Hughson, James H. Miller, Scott A Leddon, Adam Lacy-Hulbert, Dillon C. Schrock

Publikováno v: Proceedings of the National Academy of Sciences. 116:4462-4470

CD4+ follicular helper T cells (Tfh) are essential for germinal center (GC) reactions in the lymph node that generate high-affinity, long-lived plasma cells (LLPCs). Temporal GC analysis suggests B memory cells (Bmem) are generated early, while LLPCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2965f87f65cf74e51ceff58e39f90ed
https://doi.org/10.1073/pnas.1809329116

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Targeting the αv Integrins in Fibroproliferative Disease

Autor: R. J. Slack, R. J. D. Hatley, C. B. Nanthakumar

Publikováno v: Anti-fibrotic Drug Discovery ISBN: 9781788015103

Fibrosis is the formation of abnormal scar tissue following repeated tissue injury, leading to the disruption of extracellular matrix homeostasis with loss of tissue architecture and function. In the developed world, fibrosis is a leading cause of mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b162b7d79de70f58473b4e7ac19ebb16
https://doi.org/10.1039/9781788015783-00037

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Perivascular cell αv integrins as a target to treat skeletal muscle fibrosis

Autor: Maria Angélica Miglino, Pedro H.D.M. Prazeres, Rodrigo da Silva Nunes Barreto, Osvaldo Delbono, Anaelise de Oliveira Macedo Turquetti, Patrick O. Azevedo, Alexander Birbrair, Akiva Mintz

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Fibrosis following injury leads to aberrant regeneration and incomplete functional recovery of skeletal muscle, but the lack of detailed knowledge about the cellular and molecular mechanisms involved hampers the design of effective treatments. Using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bc2f22aa6149732a95641f3083381c
https://doi.org/10.1016/j.biocel.2018.04.002

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The Design of Potent, Selective and Drug-Like RGD αvβ1 Small-Molecule Inhibitors Derived from non-RGD α4β1 Antagonists

Autor: Peter Pogány, James E. Rowedder, Simon J. F. Macdonald, Morag E. Watson, Yoshiaki Washio, Richard J. D. Hatley, Sandeep Pal, Tim N. Barrett, Anna Gruszka, Daniel J. Baillache, Robert J. Slack

Publikováno v: ChemMedChem. 14(14)

Up to 45 % of deaths in developed nations can be attributed to chronic fibroproliferative diseases, highlighting the need for effective therapies. The RGD (Arg-Gly-Asp) integrin αvβ1 was recently investigated for its role in fibrotic disease, and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b627f43c7428f4e4b2b594bcca0e11
https://pubmed.ncbi.nlm.nih.gov/31207080

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