Zobrazeno 1 - 10
of 97
pro vyhledávání: '"αv integrin"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Immune system recognizes invading microbes at both pathogen and antigen levels. Toll-like receptors (TLRs) play a key role in the first-line defense against pathogens. Major functions of TLRs include cytokine and chemokine production. TLRs share comm
Externí odkaz:
https://doaj.org/article/ce97a850bb164120bb6ee1759eecb9e6
Autor:
Minxiao Yi, Ye Yuan, Li Ma, Long Li, Wan Qin, Bili Wu, Bolong Zheng, Xin Liao, Guangyuan Hu, Bo Liu
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Background Radiotherapy is the main treatment modality for thoracic tumours, but it may induce pulmonary fibrosis. Currently, the pathogenesis of radiation‐induced pulmonary fibrosis (RIPF) is unclear, and effective treatments are lacking.
Externí odkaz:
https://doaj.org/article/7848d1aaa00b40bdb73b49237ccd1d35
Akademický článek
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Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Autor:
Martin L. Decaris, Johanna R. Schaub, Chun Chen, Jacob Cha, Gail G. Lee, Megi Rexhepaj, Steve S. Ho, Vikram Rao, Megan M. Marlow, Prerna Kotak, Erine H. Budi, Lisa Hooi, Jianfeng Wu, Marina Fridlib, Shamra P. Martin, Shaoyi Huang, Ming Chen, Manuel Muñoz, Timothy F. Hom, Paul J. Wolters, Tushar J. Desai, Fernando Rock, Katerina Leftheris, David J. Morgans, Eve-Irene Lepist, Patrick Andre, Eric A. Lefebvre, Scott M. Turner
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Obj
Externí odkaz:
https://doaj.org/article/f75a5266ef724db48db905d69406f78e
Autor:
Jonathan Lagos, Sara Sagadiev, Jheimmy Diaz, Juan Pablo Bozo, Fanny Guzman, Caroline Stefani, Silvana Zanlungo, Mridu Acharya, Maria Isabel Yuseff
Publikováno v:
Cells, Vol 11, Iss 23, p 3883 (2022)
The engagement of B cells with surface-tethered antigens triggers the formation of an immune synapse (IS), where the local secretion of lysosomes can facilitate antigen uptake. Lysosomes intersect with other intracellular processes, such as Toll-like
Externí odkaz:
https://doaj.org/article/6c9744a0ca294dfaa38e8f7cf89cc240
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The presence of regulatory T cells (Tregs) in skin is important in controlling inflammatory responses in this peripheral tissue. Uninflamed skin contains a population of relatively immotile Tregs often located in clusters around hair follicles. Infla
Externí odkaz:
https://doaj.org/article/32c7ac60c9b0413381dfed41959b724a
Autor:
Xue, Yuan, Hu, Sihan, Chen, Chichi, He, Jiachen, Sun, Jie, Jin, Yesheng, Zhang, Yuanshu, Zhu, Guoqing, Shi, Qin, Rui, Yongjun
Publikováno v:
International Journal of Biological Sciences
Irisin is well-known to contribute to bone homeostasis due to its bidirectional regulation on osteogenesis and osteoclastogenesis. However, the mechanisms of irisin involved in mesenchymal stem/stromal cells (MSCs)-derived osteogenesis are still unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3722a07ca0b917486e441fd693812b3
https://doi.org/10.7150/ijbs.63505
https://doi.org/10.7150/ijbs.63505
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Autor:
Patrick Andre, Martin Decaris, Chun Chen, Munoz Manuel, Hom Timothy, Scott M. Turner, Ming Chen, Tushar J. Desai, Megan M. Marlow, Cha Jacob, Eric Lefebvre, Steve S. Ho, Paul J. Wolters, Shaoyi Huang, Eve-Irene Lepist, Katerina Leftheris, David J Morgans, Lisa Hooi, Johanna R. Schaub, Vikram R. Rao, Jianfeng Wu, Marina Fridlib, Fernando Rock, Megi Rexhepaj, Erine H. Budi, Prerna Kotak, Gail Lee, Shamra Martin
Publikováno v:
Respiratory research, vol 22, iss 1
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Objectives W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8943da51a8a3553a1e3711bc9a9ed07
https://escholarship.org/uc/item/5q12m0vq
https://escholarship.org/uc/item/5q12m0vq
Autor:
Katerina Komrskova, Pavla Postlerova, Veronika Palenikova, Eliska Valaskova, Michaela Frolikova
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9525, p 9525 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 17
International Journal of Molecular Sciences
Volume 22
Issue 17
Integrins are transmembrane receptors that facilitate cell adhesion and cell–extracellular matrix communication. They are involved in the sperm maturation including capacitation and gamete interaction, resulting in successful fertilization. αV int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bac270c47d537c45762fb441fde5fc
https://www.mdpi.com/1422-0067/22/17/9525
https://www.mdpi.com/1422-0067/22/17/9525