Zobrazeno 1 - 10
of 807
pro vyhledávání: '"αb crystallin"'
Publikováno v:
International Journal of Ophthalmology, Vol 17, Iss 10, Pp 1772-1779 (2024)
AIM: To evaluate if topical use of αB-crystallin mini-peptides supports corneal healing following flap surgery. METHODS: Cultured corneal cells were treated with fluorescent tagged αB-crystallin mini-peptides to assess its internalization. Cultured
Externí odkaz:
https://doaj.org/article/f23f232c36794e6ab5690e72c1a7a791
Publikováno v:
Fundamental Research, Vol 4, Iss 2, Pp 394-400 (2024)
Protein misfolding and aggregation are crucial pathogenic factors for cataracts, which are the leading cause of visual impairment worldwide. α-crystallin, as a small molecular chaperone, is involved in preventing protein misfolding and maintaining l
Externí odkaz:
https://doaj.org/article/15356200e4144ec184e68b4981823159
Publikováno v:
International Journal of Ophthalmology, Vol 16, Iss 3, Pp 342-347 (2023)
AIM: To evaluate the effect of epigallocatechin gallate (EGCG) in preventing lens opacity and the aggregation of lens αB-crystallin in model rats of diabetes mellitus (DM). METHODS: This experimental study included Wistar rats for DM as in vivo mode
Externí odkaz:
https://doaj.org/article/c2d62515796240078892fe1c53f2df41
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
A coordinated oxidative stress response, partly triggered by the transcription factor Nrf2, protects cells from the continual production of reactive oxygen species. Left unbuffered, reactive oxygen species can lead to protein aggregation that has bee
Externí odkaz:
https://doaj.org/article/8f3fa8a0e54f4d9b981c3dbfb156d882
Autor:
Raju Timsina, Preston Hazen, Geraline Trossi-Torres, Nawal K. Khadka, Navdeep Kalkat, Laxman Mainali
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1923 (2024)
α-Crystallin (αABc) is a major protein comprised of αA-crystallin (αAc) and αB-crystallin (αBc) that is found in the human eye lens and works as a molecular chaperone by preventing the aggregation of proteins and providing tolerance to stress.
Externí odkaz:
https://doaj.org/article/18a121cba872453793f63116ae26513d
Akademický článek
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Akademický článek
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Autor:
Elena Cannone, Valeria Guglielmi, Giulia Marchetto, Chiara Tobia, Barbara Gnutti, Barbara Cisterna, Paola Tonin, Alessandro Barbon, Gaetano Vattemi, Marco Schiavone
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11483 (2023)
Myofibrillar myopathies (MFMs) are a group of hereditary neuromuscular disorders sharing common histological features, such as myofibrillar derangement, Z-disk disintegration, and the accumulation of degradation products into protein aggregates. They
Externí odkaz:
https://doaj.org/article/972117391f7e4117aac7afc75a572df7
Autor:
Longjun Yan, Jing Li, Jialin Hu, Junwei Qu, Kejia Li, Mingli Wang, Shuang-Shuang An, Cun-cun Ke, Hui Li, Fengling Yuan, Weikai Guo, Mengyue Hu, Jing Zhang, Zhengyan Yang, Hongmei Mu, Fengyan zhang, Jun Zhang, Xiukun Cui, Yanzhong Hu
Publikováno v:
Biochemistry and Biophysics Reports, Vol 30, Iss , Pp 101227- (2022)
Genetic mutations in HSF4 cause congenital cataracts. HSF4 exhibits both positive and negative regulation on the transcription of heat shock and non-heat shock proteins during lens development, and its activity is regulated by posttranslational modif
Externí odkaz:
https://doaj.org/article/30f4559da22a4c14a3f989b27b77cf43