Zobrazeno 1 - 10
of 60
pro vyhledávání: '"αKG"'
Autor:
Zhiyang Quan, Takayoshi Awakawa
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 578-588 (2024)
Meroterpenoids are hybrid compounds that are partially derived from terpenoids. This group of natural products displays large structural diversity, and many members exhibit beneficial biological activities. This mini-review highlights recent advances
Externí odkaz:
https://doaj.org/article/029edf437f3c4c208f727eed356e03cc
Mitochondrial-to-nuclear communications through multiple routes regulate cardiomyocyte proliferation
Publikováno v:
Cell Regeneration, Vol 13, Iss 1, Pp 1-4 (2024)
Abstract The regenerative capacity of the adult mammalian heart remains a formidable challenge in biological research. Despite extensive investigations into the loss of regenerative potential during evolution and development, unlocking the mechanisms
Externí odkaz:
https://doaj.org/article/cc095e65c055475fb859bcea148a0d56
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The multifunctional molecules mechanistic target of rapamycin (mTOR) and α-ketoglutarate (αKG) are crucial players in the regulatory mechanisms that maintain cell homeostasis in an ever-changing environment. Cerebral ischemia is associated primaril
Externí odkaz:
https://doaj.org/article/8477c527b1f046e0a8fc33e007a01ba1
Publikováno v:
Engineering Microbiology, Vol 3, Iss 1, Pp 100062- (2023)
Fe(II)/α-ketoglutarate (αKG)-dependent oxygenases catalyze the oxidative modification of various molecules, from DNA, RNA, and proteins to primary and secondary metabolites. They also catalyze a variety of biochemical reactions, including hydroxyla
Externí odkaz:
https://doaj.org/article/1fb0d1ddb08642ac907e2f05df37820b
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Yoichi Sekita, Yuki Sugiura, Akari Matsumoto, Yuki Kawasaki, Kazuya Akasaka, Ryo Konno, Momoka Shimizu, Toshiaki Ito, Eiji Sugiyama, Terushi Yamazaki, Eriko Kanai, Toshinobu Nakamura, Makoto Suematsu, Fumitoshi Ishino, Yoshio Kodera, Takashi Kohda, Tohru Kimura
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2021)
Abstract Background Phosphoinositide-3 kinase (PI3K)/AKT signaling participates in cellular proliferation, survival and tumorigenesis. The activation of AKT signaling promotes the cellular reprogramming including generation of induced pluripotent ste
Externí odkaz:
https://doaj.org/article/305914cc50854a9697a903f692dbfafd
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Nishith M Shrimali, Sakshi Agarwal, Simrandeep Kaur, Sulagna Bhattacharya, Sankar Bhattacharyya, Josef T Prchal, Prasenjit Guchhait
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103672- (2021)
Background: Phospho-Akt1 (pAkt1) undergoes prolyl hydroxylation at Pro125 and Pro313 by the prolyl hydroxylase-2 (PHD2) in a reaction decarboxylating α-ketoglutarate (αKG). We investigated whether the αKG supplementation could inhibit Akt-mediated
Externí odkaz:
https://doaj.org/article/1f095c1e831047149bf72cc927d00585
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Berrak Ugur, Huan Bao, Michal Stawarski, Lita R. Duraine, Zhongyuan Zuo, Yong Qi Lin, G. Gregory Neely, Gregory T. Macleod, Edwin R. Chapman, Hugo J. Bellen
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3794-3806 (2017)
Neurotransmission is a tightly regulated Ca2+-dependent process. Upon Ca2+ influx, Synaptotagmin1 (Syt1) promotes fusion of synaptic vesicles (SVs) with the plasma membrane. This requires regulation at multiple levels, but the role of metabolites in
Externí odkaz:
https://doaj.org/article/b24801dd51874639a39d00f98dc8ed88