Zobrazeno 1 - 10
of 666
pro vyhledávání: '"αIIbβ3"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Integrin αIIbβ3 is the predominant receptor for fibrinogen which mediates platelet aggregation, an important step in hemostasis and thrombosis. Several mutations have been reported in the genes encoding αIIb and β3 subunits among patient
Externí odkaz:
https://doaj.org/article/1c8366f51ae14188832fc7cf752632de
Autor:
Zhenzhen Zhao, Yixin Cheng, Yaqiong Zhang, Meinan Peng, Yue Han, Depei Wu, Aizhen Yang, Yi Wu
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 5, Pp 102524- (2024)
Background: Previous studies have shown that thiol isomerases such as ERp46 positively regulate platelet function by reducing integrin αIIbβ3 disulfides, and the transmembrane thiol isomerase TMX1 negatively regulates integrin αIIbβ3 activation.
Externí odkaz:
https://doaj.org/article/24c3bec525974e6db6e9fb4ac22ff4d6
Autor:
Jinmi Zou, Siyu Sun, Ilaria De Simone, Hugo ten Cate, Philip G. de Groot, Bas de Laat, Mark Roest, Johan W.M. Heemskerk, Frauke Swieringa
Publikováno v:
TH Open, Vol 08, Iss 02, Pp e232-e242 (2024)
Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation. The signal
Externí odkaz:
https://doaj.org/article/a1a44a63b65c416f94bc44b92ad11959
Publikováno v:
Annals of Medicine, Vol 55, Iss 1, Pp 1102-1110 (2023)
AbstractBackground/objective Type 2 diabetes is a major risk factor for atherosclerotic disease. It is well agreed that the reactivity of diabetic platelets is increased but how platelet reactivity regulates is unknown. In our laboratory, density sep
Externí odkaz:
https://doaj.org/article/41e07d64a34149d68999bc3385bf390a
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 9, p 325 (2024)
Background: Platelets have the hemostatic function, and their aberrant activation is associated with occlusive thrombus formation. Plasma exosomes are rich in platelets containing ubiquitin-specific peptidase 15 (USP15). Herein, we aim to explore the
Externí odkaz:
https://doaj.org/article/7b9342ef6da240f6b3956595170f8739
Publikováno v:
TH Open, Vol 08, Iss 01, Pp e96-e105 (2024)
Externí odkaz:
https://doaj.org/article/00de3a75164144a98be2428d0016e128
Autor:
Wei-Chieh Huang, Thanasekaran Jayakumar, Joen-Rong Sheu, Chih-Wei Hsia, Chih-Hsuan Hsia, Ting-Lin Yen, Chao-Chien Chang
Publikováno v:
Chinese Medicine, Vol 18, Iss 1, Pp 1-15 (2023)
Abstract Background Platelets play a crucial role in cardiovascular diseases (CVDs) and are activated by endogenous agonists like collagen. These agonists initiate signal transduction through specific platelet receptors, resulting in platelet aggrega
Externí odkaz:
https://doaj.org/article/08cd4386dd7e433882de1f0309f958d2
Autor:
Yi Chang, Chih-Wei Hsia, Wei-Chieh Huang, Thanasekaran Jayakumar, Chih-Hsuan Hsia, Ting-Lin Yen, Joen-Rong Sheu, Shaw-Min Hou
Publikováno v:
Heliyon, Vol 9, Iss 10, Pp e20286- (2023)
Platelets play a vital role in the formation of dangerous arterial thrombosis. Platelets are activated by adhesive proteins or soluble agonists through their specific receptors. The receptor-mediated signaling pathways lead to common signaling events
Externí odkaz:
https://doaj.org/article/6afe699405ae4e828d1494bec7b1eece
Publikováno v:
Thrombosis Journal, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Integrins are heterodimeric receptors comprising α and β subunits. They are expressed on the cell surface and play key roles in cell adhesion, migration, and growth. Several types of integrins are expressed on the platelets, including αv
Externí odkaz:
https://doaj.org/article/92ee379b93b24279b3fbca6e00314d92
Autor:
Sutherland, Mark, Gordon, Andrew, Al-Shammari, F.O.F.O., Throup, Adam E., La Corte, A.C., Philippou, H., Shnyder, Steven, Patterson, Laurence H., Sheldrake, Helen M.
Yes
The Arg-Gly-Asp (RGD)-binding family of integrin receptors, and notably the β3 subfamily, are key to multiple physiological processes involved in tissue development, cancer proliferation, and metastatic dissemination. While there is compell
The Arg-Gly-Asp (RGD)-binding family of integrin receptors, and notably the β3 subfamily, are key to multiple physiological processes involved in tissue development, cancer proliferation, and metastatic dissemination. While there is compell
Externí odkaz:
http://hdl.handle.net/10454/19561
