Dexmedetomidine’s inhibitory effects on acetylcholine release from cholinergic nerves in guinea pig trachea: a mechanism that accounts for its clinical benefit during airway irritation

Autor: Maya Mikami, Yi Zhang, Benjamin Kim, Tilla S. Worgall, Harald Groeben, Charles W. Emala

Publikováno v: BMC Anesthesiology, Vol 17, Iss 1, Pp 1-11 (2017)

Abstract Background Airway instrumentation can evoke upper airway reflexes including bronchoconstriction and cough which can cause serious complications including airway trauma, laryngospasm or bronchospasm which may in turn lead to difficulty with v

Externí odkaz: https://doaj.org/article/337aa89a58ce43848cedcf77391e8b43

Vatinoxan: a new development in the clinical use of α2-adrenoceptor agonists in dogs, part 1

Autor: Rachel C. Bennett

Publikováno v: Companion Animal. 26:176-181

Vatinoxan, formerly known as MK-467 or L-659 066, is a peripherally acting α2 adrenoceptor antagonist. In a similar manner to atipamezole, it antagonises the pharmacodynamic effects of the α2 adrenoceptor agonist medetomidine and its active enantio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b524accf8a3c65cd19db0238b16a29e
https://doi.org/10.12968/coan.2021.0040

Effect of Different Doses of Atipamezole on Reversal of Medetomidine-Induced Tear-Flow Decrease in Rats

Autor: Takamasa Itoi, Toshinori Furukawa, Teppei Kanda, Kayo Furumoto, Ayumi Makino, Yuki Shimizu, Noritaka Maeta, Manami Gotoh

Publikováno v: Veterinary Sciences, Vol 7, Iss 197, p 197 (2020)
Veterinary Sciences
Volume 7
Issue 4

It has been reported that &alpha
2-adrenoceptor agonists such as medetomidine decrease tear flow in many species, including rats. Few studies have investigated the involvement of &alpha
2-adrenoceptor in decreased tear flow
the issue h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d875109d620a875ca75aeae78378ed9
https://www.mdpi.com/2306-7381/7/4/197

A novel and facile route for the synthesis of medetomidine as the α2-adrenoceptor agonist

Autor: Leila Behrouzi, Hiroshi Aoyama, Foad Kazemi, Hamideh Haghighat, Tsutomu Yokomatsu, Samira Aieni, Babak Kaboudin, Jun-ya Kato

Publikováno v: Journal of the Iranian Chemical Society. 14:1735-1739

We report here a novel and facile method for the synthesis of (±)-4(5)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole (medetomidine) in a good yield in five steps. The method involves Wittig olefination of the phenylimidazolylketones, followed by a hydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1eba68ddf357a6e55299a00f731fafa9
https://doi.org/10.1007/s13738-017-1114-0

Preparative Separation and Structural Identification of Impurities of a New α2-Adrenoceptor Agonist Using Stacking Injection, LC-MSn and LC-SPE-NMR

Autor: Regina V. Oliveira, Ivan da Rocha Pitta, Tiago Venâncio, Josiane de Oliveira Cardoso, Maria do Carmo Alves de Lima, Sérgio Scherrer Thomasi

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 28, Issue: 6, Pages: 1038-1047, Published: JUN 2017
Journal of the Brazilian Chemical Society v.28 n.6 2017
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

Identifying impurities in drug substances has become one of the most important issues in pharmaceutical analysis since it can have a significant impact on the efficacy of new pharmaceutical products. Due to the purity requirements, in this paper a ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808324dfb40c632e9dcaebb1705b29fd
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000601038&lng=en&tlng=en