Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions

Autor: Xiangling Meng, Christopher M McGraw, Wei Wang, Junzhan Jing, Szu-Ying Yeh, Li Wang, Joanna Lopez, Amanda M Brown, Tao Lin, Wu Chen, Mingshan Xue, Roy V Sillitoe, Xiaolong Jiang, Huda Y Zoghbi

Publikováno v: eLife, Vol 8 (2019)

Neurexophilins are secreted neuropeptide-like glycoproteins, and neurexophilin1 and neurexophilin3 are ligands for the presynaptic cell adhesion molecule α-neurexin. Neurexophilins are more selectively expressed in the brain than α-neurexins, howev

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Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions.

Autor: Meng X; Department of Neuroscience, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States., McGraw CM; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Program in Developmental Biology, Baylor College of Medicine, Houston, United States., Wang W; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States., Jing J; Department of Neuroscience, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States., Yeh SY; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Program in Developmental Biology, Baylor College of Medicine, Houston, United States., Wang L; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States., Lopez J; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States., Brown AM; Department of Neuroscience, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, United States., Lin T; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, United States., Chen W; Department of Neuroscience, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States., Xue M; Department of Neuroscience, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Program in Developmental Biology, Baylor College of Medicine, Houston, United States.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.; The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States., Sillitoe RV; Department of Neuroscience, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Program in Developmental Biology, Baylor College of Medicine, Houston, United States.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, United States., Jiang X; Department of Neuroscience, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States., Zoghbi HY; Department of Neuroscience, Baylor College of Medicine, Houston, United States.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.; Program in Developmental Biology, Baylor College of Medicine, Houston, United States.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, United States.

Publikováno v: ELife [Elife] 2019 Sep 16; Vol. 8. Date of Electronic Publication: 2019 Sep 16.