Zobrazeno 1 - 10
of 260
pro vyhledávání: '"α-Synucleinopathy"'
Autor:
Elisabet Jakova, Omozojie P. Aigbogun, Mohamed Taha Moutaoufik, Kevin J. H. Allen, Omer Munir, Devin Brown, Changiz Taghibiglou, Mohan Babu, Chris P. Phenix, Ed S. Krol, Francisco S. Cayabyab
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9386 (2024)
We previously found that chronic adenosine A1 receptor stimulation with N6-Cyclopentyladenosine increased α-synuclein misfolding and neurodegeneration in a novel α-synucleinopathy model, a hallmark of Parkinson’s disease. Here, we aimed to synthe
Externí odkaz:
https://doaj.org/article/661d72e5899d41dc9dfb46ad9d0e0d15
Publikováno v:
Nature and Science of Sleep, Vol Volume 15, Pp 691-703 (2023)
Jung-Ick Byun,1 Tae-Won Yang,2– 4 Jun-Sang Sunwoo,5 Won Chul Shin,1,6 Oh-Young Kwon,2,4,7,* Ki-Young Jung8,* 1Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Republic of Ko
Externí odkaz:
https://doaj.org/article/93a56ed655e048679adfb1e29ecac1b2
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
BackgroundThe importance of ferroptosis and the immune system has been mentioned in the pathogenesis of α-synucleinopathy. The α-synuclein-immunoreactive inclusions that primarily affect oligodendrocytes are the hallmark of multiple system atrophy
Externí odkaz:
https://doaj.org/article/9209b1a08c304bd3b1796d39b8f29f09
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1223 (2024)
Abnormal aggregation of α-synuclein is the hallmark of neurodegenerative diseases, classified as α-synucleinopathies, primarily occurring sporadically. Their onset is associated with an interaction between genetic susceptibility and environmental f
Externí odkaz:
https://doaj.org/article/b28d154e87c14abf9aae6dbb1aa1dae0
Autor:
John Fonda Crary
Publikováno v:
Free Neuropathology, Vol 4 (2023)
This paper reviews ten highly impactful studies published in the previous year selected by the author from the neurodegenerative neuropathology literature. As in previous years, the focus is to highlight human tissue-based experimentation most releva
Externí odkaz:
https://doaj.org/article/daecd2097e74494680d387491fb9dc09
Akademický článek
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Autor:
Ichiro Kawahata, Kohji Fukunaga
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 2, Pp 248-254 (2022)
An aging society leads to an increased number of patients with cognitive and movement disorders, such as Parkinson's disease and dementia with Lewy bodies. α-Synuclein accumulation in neuronal cells is a pathological hallmark of α-synucleinopathies
Externí odkaz:
https://doaj.org/article/a4460930b1e44580aa29db82cf8d998f
Autor:
Mika Hayakawa, Tomoyasu Matsubara, Yoko Mochizuki, Chisen Takeuchi, Motoyuki Minamitani, Masayuki Imai, Kenjiro Kosaki, Tomio Arai, Shigeo Murayama
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background The detailed neuropathological features of patients with autosomal recessive hereditary spastic paraplegia with a thin corpus callosum (TCC) and SPG11 mutations are poorly understood, as only a few autopsies have been reported. He
Externí odkaz:
https://doaj.org/article/65737180a3ed4d4b824a504c07a51d85
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 1, Pp n/a-n/a (2023)
Abstract The scope of the present review is to synthesize existing literature data on fluid biomarkers for Parkinson's disease (PD) and atypical parkinsonian syndromes (APS). Parkinsonian syndromes encompass a body of heterogeneous neurodegenerative
Externí odkaz:
https://doaj.org/article/815925c12c554223a2eb091bd88b04f4
Autor:
Jeong-Yong Shin, Bina Lee, Sangwoo Ham, Ji Hun Kim, Hyojung Kim, Heejeong Kim, Min Gi Jo, Hye Jung Kim, Sang Won Park, Hee-Seok Kweon, Yong Jun Kim, Seung Pil Yun, Yunjong Lee
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113908- (2022)
The aggregation of aminoacyl transfer RNA synthetase complex-interacting multifunctional protein-2 (AIMP2) accelerates α-synuclein aggregation via direct interaction, leading to enhanced dopaminergic neurotoxicity in Parkinson’s disease (PD). Thus
Externí odkaz:
https://doaj.org/article/384194fc65bd47e6acd7a06f169bd83a