Zobrazeno 1 - 10
of 148
pro vyhledávání: '"α-KG"'
Autor:
Ran Ding, Yongfeng Zhou, Qi Zhang, Xiangjie Kong, Qi Li, Sheng Zhang, Yibing Chen, Xinglan An, Ziyi Li
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The Myc family is essential for cell proliferation, differentiation, and metabolism, particularly in embryonic development and stem cell functions. However, the specific role of Myc in porcine early embryonic development is not fully understood. This
Externí odkaz:
https://doaj.org/article/34277e0cd50a4e38b8fd3564ffb1989a
Autor:
Andrey Volnitskiy, Konstantin Shabalin, Rimma Pantina, Elena Varfolomeeva, Roman Kovalev, Vladimir Burdakov, Svetlana Emelianova, Luiza Garaeva, Alexander Yakimov, Marina Sogoyan, Michael Filatov, Andrey L. Konevega, Tatiana Shtam
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 2, Pp 1107-1120 (2024)
The OCT4 transcription factor is necessary to maintain cell stemness in the early stages of embryogenesis and is involved in the formation of induced pluripotent stem cells, but its role in oncogenesis is not yet entirely clear. In this work, OCT4 ex
Externí odkaz:
https://doaj.org/article/240e4b208c2f418dbc1bf9dccd2c40d6
Autor:
Ji‐Yan Wang, Xin‐Tong Dai, Qing‐Le Gao, Hong‐Kai Chang, Shuai Zhang, Chang‐Liang Shan, Tao He
Publikováno v:
Ibrain, Vol 9, Iss 2, Pp 133-147 (2023)
Abstract Due to the existence of the blood–brain barrier in glioma, traditional drug therapy has a poor therapeutic outcome. Emerging immunotherapy has been shown to have satisfactory therapeutic effects in solid tumors, and it is clinically instru
Externí odkaz:
https://doaj.org/article/186cbac1f76941379f3b443df02d6212
Publikováno v:
Molecules, Vol 29, Iss 8, p 1861 (2024)
Alpha-ketoglutaric acid (α-KG), as an intermediate product of the tricarboxylic acid cycle, plays a crucial role in peptide and amino acid synthesis. In order to reduce costs and improve efficiency in the oxidative production of α-ketoglutaric acid
Externí odkaz:
https://doaj.org/article/3661a23ceeb444a3a899033e35133941
Akademický článek
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Akademický článek
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Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Background There is a lack of effective therapies for enteric nervous system (ENS) injury. Our previous study showed that transplanted bone marrow-derived mesenchymal stem cells (BMSCs) play a “glia-like cells” role in initiating ENS reg
Externí odkaz:
https://doaj.org/article/025c02c073124aa88c635025c2b9cb68
Autor:
Zheyi Xiang, Le Bai, Jennifer Q. Zhou, Ricardo R. Cevallos, Jonathan R. Sanders, Gang Liu, Karen Bernard, Yan Y. Sanders
Publikováno v:
Molecular Metabolism, Vol 67, Iss , Pp 101655- (2023)
Objective: Excessive extra-cellular-matrix production and uncontrolled proliferation of the fibroblasts are characteristics of many fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). The fibroblasts have enhanced glutaminolysis with up
Externí odkaz:
https://doaj.org/article/dd95ae331d94429bab83a46d0b50dd73
Akademický článek
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Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The inhibition of alpha-ketoglutarate (α-KG)-dependent dioxygenases is thought to contribute to isocitrate dehydrogenase (IDH) mutation-derived malignancy. Herein, we aim to thoroughly investigate the expression pattern and prognostic significance o
Externí odkaz:
https://doaj.org/article/0dcffdcdcdab4b13a2325014862a8da5