Výsledky vyhledávání - "α methylacyl coa racemase"

Akademický článek

α-Methylacyl-CoA Racemase from Mycobacterium tuberculosis—Detailed Kinetic and Structural Characterization of the Active Site

Autor: Otsile O. Mojanaga, Timothy J. Woodman, Matthew D. Lloyd, K. Ravi Acharya

Publikováno v: Biomolecules, Vol 14, Iss 3, p 299 (2024)

α-Methylacyl-CoA racemase in M. tuberculosis (MCR) has an essential role in fatty acid metabolism and cholesterol utilization, contributing to the bacterium’s survival and persistence. Understanding the enzymatic activity and structural features o

Externí odkaz: https://doaj.org/article/d66d65e2902d46ff934b3d658be25e44

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Akademický článek

IMMUNOHISTOCHEMICAL ANALYSIS AS A METHOD FOR INCREASING THE DETECTION OF PROSTATE CANCER IN PRIMARY BIOPSY

Autor: S. V. Popov, R. G. Guseynov, O. N. Skryabin, I. N. Orlov, A. A. Vorobyov, A. G. Martov, V. L. Shchukin

Publikováno v: Issledovaniâ i Praktika v Medicine, Vol 6, Iss 1, Pp 41-49 (2019)

Morphological manifestations of prostate cancer (PCa) in 15–20% of cases are similar to those with benign hyperplastic processes in prostate tissue and/or with a histological pattern of atypical small acinar proliferation (ASAP).The purpose of this

Externí odkaz: https://doaj.org/article/997183da92314201b6c8e9ef53cc9e6e

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Akademický článek

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Relationship Between Biopsy Core α-Methylacyl-CoA Racemase Positivity and Five-Year Biochemical Recurrence in D’Amico Low- and Intermediate-Risk Prostate Cancer

Autor: Burak Arslan, Ersin Gökmen, Oktay Özman, Serkan Gönültaş, Murat Kars

Publikováno v: Üroonkoloji Bülteni, Vol 20, Iss 2, Pp 92-95 (2021)

Objective:This study aims to explore the association between alpha methylacyl A coenzyme racemase (AMACR)/P504S staining intensity of prostate biopsy cores and five-year biochemical recurrence after radical prostatectomy in patients diagnosed with lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bb8233c8bd82bdc37d6c8c2f89e1a8
https://doi.org/10.4274/uob.galenos.2020.1721

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Combined α-methylacyl-CoA racemase inhibition and docetaxel treatment reduce cell proliferation and decrease expression of heat shock protein 27 in androgen receptor-variant-7–positive prostate cancer cells

Autor: Atsuhiko Yoshizawa, Kosuke Fukaya, Kenji Zennami, Masanobu Saruta, Takuhisa Nukaya, Hitomi Sasaki, Makoto Sumitomo, Ryoichi Shiroki, Mamoru Kusaka, Manabu Ichino, Atsuko Niimi, Kiyoshi Takahara, Motoshi Suzuki, Naohiko Fukami

Publikováno v: Prostate International
Prostate International, Vol 9, Iss 1, Pp 18-24 (2021)

Background Disease progression in castrate-resistant prostate cancer (PCa) is most commonly driven by the reactivation of androgen receptor (AR) signaling and involves AR splice variants including ARV7. Materials and methods We used the ARV7-positive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cc2fec2c258ffc034e7d611f5a0db5
http://europepmc.org/articles/PMC8053692

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Akademický článek

The influence of the branched-chain fatty acids pristanic acid and Refsum disease-associated phytanic acid on mitochondrial functions and calcium regulation of hippocampal neurons, astrocytes, and oligodendrocytes

Autor: Sabine Rönicke, Nicol Kruska, Stefan Kahlert, Georg Reiser

Publikováno v: Neurobiology of Disease, Vol 36, Iss 2, Pp 401-410 (2009)

Pristanic acid and phytanic acid are branched-chain fatty acids, which play an important role in diseases with peroxisomal impairment, like Refsum disease (MIM 266500), Zellwegers syndrome and α-methylacyl-CoA racemase deficiency (MIM 604489). Sever

Externí odkaz: https://doaj.org/article/861a8049f2164bffa22d5e5f12111929

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Akademický článek

Bile acids: the role of peroxisomes

Autor: Sacha Ferdinandusse, Simone Denis, Phyllis L. Faust, Ronald J.A. Wanders

Publikováno v: Journal of Lipid Research, Vol 50, Iss 11, Pp 2139-2147 (2009)

It is well established that peroxisomes play a crucial role in de novo bile acid synthesis. Studies in patients with a peroxisomal disorder have been indispensable for the elucidation of the precise role of peroxisomes. Several peroxisomal disorders

Externí odkaz: https://doaj.org/article/c9930892d08d493f995c0cd6ffbe84cf

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Structure-activity relationships of rationally designed AMACR 1A inhibitors

Autor: Guat Ling Lee, Maksims Yevglevskis, Tony D. James, Amit Nathubhai, Michael D. Threadgill, Timothy J. Woodman, Matthew D. Lloyd, Yoana D. Petrova

Publikováno v: Jevglevskis, M, Lee, G L, Nathubhai, A, Petrova, Y, James, T, Threadgill, M, Woodman, T & Lloyd, M 2018, ' Structure-activity relationships of rationally designed AMACR 1A inhibitors ', Bioorganic and Medicinal Chemistry, vol. 79, pp. 145-154 . https://doi.org/10.1016/j.bioorg.2018.04.024

α-Methylacyl-CoA racemase (AMACR; P504S) is a promising novel drug target for prostate and other cancers. Assaying enzyme activity is difficult due to the reversibility of the ‘racemisation’ reaction and the difficulties in the separation of epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59197f08a7a3fa30734d3e45afadcb6
https://doi.org/10.1016/j.bioorg.2018.04.024

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