Zobrazeno 1 - 10
of 573
pro vyhledávání: '"α galactosylceramide"'
Autor:
Adam Nelson, Nichole McMullen, Simon Gebremeskel, Roberto De Antueno, Duncan Mackenzie, Roy Duncan, Brent Johnston
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-17 (2024)
Abstract Background Metastatic breast cancer is a leading cause of cancer death in woman. Current treatment options are often associated with adverse side effects and poor outcomes, demonstrating the need for effective new treatments. Immunotherapies
Externí odkaz:
https://doaj.org/article/149fda54df0043feaa5581db68f00768
Autor:
Bianca L. Artiaga, Daniel Madden, Taeyong Kwon, Chester McDowell, Cassidy Keating, Velmurugan Balaraman, Darling Melany de Carvahlo Madrid, Laurie Touchard, Jamie Henningson, Philip Meade, Florian Krammer, Igor Morozov, Juergen A. Richt, John P. Driver
Publikováno v:
Vaccines, Vol 12, Iss 9, p 1068 (2024)
Invariant natural killer T (iNKT) cells are glycolipid-reactive T cells with potent immunoregulatory properties. iNKT cells activated with the marine-sponge-derived glycolipid, α-galactosylceramide (αGC), provide a universal source of T-cell help t
Externí odkaz:
https://doaj.org/article/4868f73269404e89aa4a6ae8e8623447
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPeanut allergy is one of the most prevalent food allergies globally. Currently, most research into the mechanisms involved in protein allergy focuses on the protein allergens under investigation, and information on the function of accompa
Externí odkaz:
https://doaj.org/article/e9d90058355144b693a38ed8c297734e
Publikováno v:
Annals of Medicine, Vol 54, Iss 1, Pp 2233-2245 (2022)
Background Immune responses are important in the progression of non-alcoholic fatty liver disease (NAFLD). Natural killer T (NKT) cells are main components of the innate immune system that modulate immunity. However, the role of NKT cells in NAFLD re
Externí odkaz:
https://doaj.org/article/caaa40aa2b4e4ada9438a5551dd9bc16
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Bianca L. Artiaga, Igor Morozov, Russell Ransburgh, Taeyong Kwon, Velmurugan Balaraman, Sabarish V. Indran, Darling Melany De Carvalho Madrid, Weihong Gu, Jamie Henningson, Wenjun Ma, Jürgen A. Richt, John P. Driver
Publikováno v:
Animal Diseases, Vol 2, Iss 1, Pp 1-15 (2022)
Abstract Natural killer T (NKT) cells activated with the glycolipid ligand α-galactosylceramide (α-GalCer) stimulate a wide variety of immune cells that enhance vaccine-mediated immune responses. Several studies have used this approach to adjuvant
Externí odkaz:
https://doaj.org/article/ea1265ba55ee48449878b912d3357abe
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Whitney Rabacal, Finja Schweitzer, Heather M. Kling, Lizabeth Buzzelli, Emily Rayens, Karen A. Norris
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionPneumocystis is a ubiquitous fungal pathogen that causes pneumonia (PCP) and pulmonary sequelae in HIV-infected individuals and other immunocompromised populations. With the success of anti-retroviral therapy for HIV-infected individuals
Externí odkaz:
https://doaj.org/article/9fcabf92075f4fc89f7d95a91d29657f
Autor:
Qiaochu Lin, Meggie Kuypers, Zhewei Liu, Julia K Copeland, Donny Chan, Susan J Robertson, Jean Kontogiannis, David S Guttman, E. Kate Banks, Dana J Philpott, Thierry Mallevaey
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytot
Externí odkaz:
https://doaj.org/article/545f76b4b1774dba9ea0db17924006eb
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The synthesis of α-galactosylceramide (KRN7000) and its C-6 modified analogs remains a challenge due to the difficult α-1,2-cis-glycosidic bond. A non-participating benzyl (Bn) protecting group has been commonly used to favor the α-glycosylation p
Externí odkaz:
https://doaj.org/article/8d0a486a1f344b03ab8061756b097b3c