Zobrazeno 1 - 10
of 1 167
pro vyhledávání: '"α‐ketoglutarate"'
Autor:
Zhuozhi Wang, Jue Hu, Jeffrey S. Marschall, Ling Yang, Erliang Zeng, Shaoping Zhang, Hongli Sun
Publikováno v:
Small Science, Vol 4, Iss 10, Pp n/a-n/a (2024)
α‐ketoglutarate (AKG), a key component of the tricarboxylic acid cycle, has attracted attention for its antiaging properties. In the recent study, it is indicated that locally delivered cell‐permeable AKG significantly promotes osteogenic differ
Externí odkaz:
https://doaj.org/article/94c720d1182044c4977c7dea8981dea3
Autor:
Rong He, Yuchi Wei, Zeyu Peng, Jie Yang, Zhenwei Zhou, Ailin Li, Yongji Wu, Mingyue Wang, Xiangyan Li, Daqing Zhao, Zhonghua Liu, Haisi Dong, Xiangyang Leng
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-20 (2024)
Abstract Osteoarthritis (OA) is the most common degenerative joint disorder that causes disability in aged individuals, caused by functional and structural alterations of the knee joint. To investigate whether metabolic drivers might be harnessed to
Externí odkaz:
https://doaj.org/article/97d5651922a74afbb57cbaeefa279b09
Autor:
Qing Liu, Linqing Zhang, Zhen Chen, Yihan He, Yuhang Huang, Cui Qiu, Chengwen Zhu, Danxia Zhou, Zhenji Gan, Xia Gao, Guoqiang Wan
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract Cochlear hair cells are the sensory cells responsible for transduction of acoustic signals. In mammals, damaged hair cells do not regenerate, resulting in permanent hearing loss. Reprogramming of the surrounding supporting cells to functiona
Externí odkaz:
https://doaj.org/article/570456d1e41a4f4dbb0065986b0b3628
Autor:
Danyu Cheng, Mo Zhang, Yezi Zheng, Min Wang, Yilin Gao, Xudong Wang, Xuyun Liu, Weiqiang Lv, Xin Zeng, Konstantin N. Belosludtsev, Jiacan Su, Lin Zhao, Jiankang Liu
Publikováno v:
Redox Biology, Vol 74, Iss , Pp 103230- (2024)
α-Ketoglutarate (AKG), a crucial intermediate in the tricarboxylic acid cycle, has been demonstrated to mitigate hyperlipidemia-induced dyslipidemia and endothelial damage. While hyperlipidemia stands as a major trigger for non-alcoholic fatty liver
Externí odkaz:
https://doaj.org/article/24cffce7e43c4c43a2f0cc7061260deb
Autor:
Hao Yu, Daojing Gan, Zhen Luo, Qilin Yang, Dongqi An, Hao Zhang, Yingchun Hu, Zhuang Ma, Qingchun Zeng, Dingli Xu, Hao Ren
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-14 (2024)
Abstract Background In heart failure (HF), mitochondrial dysfunction and metabolic remodeling lead to a reduction in energy productivity and aggravate cardiomyocyte injury. Supplementation with α-ketoglutarate (AKG) alleviated myocardial hypertrophy
Externí odkaz:
https://doaj.org/article/c690094507a04a0e8f2266ae076e04fa
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Angiogenesis is essential for tissue repair in ischemic diseases, relying on glycolysis as its primary energy source. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1), the catalytic subunit of collagen prolyl 4-hydroxylase, is a glyco
Externí odkaz:
https://doaj.org/article/10fb5c6eb17f4118ba7ea521ec4aaf30
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background trans-4-Hydroxyproline (T-4-HYP) is a promising intermediate in the synthesis of antibiotic drugs. However, its industrial production remains challenging due to the low production efficiency of T-4-HYP. This study focused on desig
Externí odkaz:
https://doaj.org/article/5e26f1578fe94cb9a89bb12012b116a9
Autor:
Duo Tang, Yuchen Zheng, Guozhen Wang, Chao Sheng, Zijia Liu, Biqi Wang, Qi Zong, Yuchen Zhang, Xiaonan Hou, Mengfei Yao, Zhixiang Zhou
Publikováno v:
FEBS Open Bio, Vol 13, Iss 8, Pp 1522-1535 (2023)
Oncogene E6 plays a critical role in the development and progression of esophageal cancer caused by human papillomavirus (HPV) infection. Alpha‐ketoglutarate (AKG) is a key metabolite in the tricarboxylic acid cycle and has been widely used as a di
Externí odkaz:
https://doaj.org/article/e91020a105fa494aaf853dc73c46fdd1
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 470 (2024)
Imbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates the development of osteoporosis, which is the leading risk factor of disability in the elderly. Harmonizing the metabolic actions of bone-making cells and bone reso
Externí odkaz:
https://doaj.org/article/39e1afc5e1604e79b9b585a646d6ebe5
Autor:
Yang Kong, Pei‐Kang Liu, Yao Li, Nicholas D Nolan, Peter M J Quinn, Chun‐Wei Hsu, Laura A Jenny, Jin Zhao, Xuan Cui, Ya‐Ju Chang, Katherine J Wert, Janet R Sparrow, Nan‐Kai Wang, Stephen H Tsang
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp 1-20 (2023)
Abstract Iron accumulation causes cell death and disrupts tissue functions, which necessitates chelation therapy to reduce iron overload. However, clinical utilization of deferoxamine (DFO), an iron chelator, has been documented to give rise to syste
Externí odkaz:
https://doaj.org/article/dad16b5228fa4f2aae01a11f4bb1e21e