Zobrazeno 1 - 10
of 1 639
pro vyhledávání: '"Β-SECRETASE"'
Autor:
Sirinapa Thangsiri, Woorawee Inthachat, Piya Temviriyanukul, Yuraporn Sahasakul, Piyapat Trisonthi, Wanida Pan-utai, Dalad Siriwan, Uthaiwan Suttisansanee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Cyanobacteria, especially Arthrospira, are valuable resources of nutrients and natural pigments with many beneficial health-related properties. This study optimized the extraction conditions of Arthrospira to achieve high phenolic contents a
Externí odkaz:
https://doaj.org/article/77bde799c9954094a60f4401ee563ebf
Autor:
Richa Arya, Smita Jain, Sarvesh Paliwal, Kirtika Madan, Swapnil Sharma, Achal Mishra, Prashant Tiwari, Sunil Kumar Kadiri
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 9, Pp 369-381 (2024)
Alzheimer’s disease is a neurological disorder marked by the accumulation of amyloid beta (Aβ) aggregates, resulting from mutations in the amyloid precursor protein. The enzyme β-secretase, also known as β-site amyloid precursor protein cleaving
Externí odkaz:
https://doaj.org/article/951eb488d02145528b4cd5f5f3dabbf5
Autor:
Takeru Nagayama, Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Takashi Saito, Takaomi C. Saido, Shuji Wakatsuki, Toshiyuki Araki
Publikováno v:
Neuroscience Research, Vol 205, Iss , Pp 40-46 (2024)
Sleep apnea is regarded as an important risk factor in the pathogenesis of Alzheimer disease (AD). Chronic intermittent hypoxia treatment (IHT) given during the sleep period of the circadian cycle in experimental animals is a well-established sleep a
Externí odkaz:
https://doaj.org/article/2970af987d6f457b9f2fbe1bf4d1e0a0
Autor:
Ya Su, Qiong Wang, Feng Gao, Jiajie Xu, Jiayu Fu, Yunqing Ying, Yiwei Xia, Xiaoxiao Wang, Qiang Dong, Yong Shen, Xin Cheng
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 24 (2024)
Background β‐secretase 1 (BACE1) plays a key role in amyloidogenic pathway and is considered a new mechanism for cerebral small vessel disease (CSVD). We explore the potential role of plasma BACE1 in CSVD and the pathological process it may be inv
Externí odkaz:
https://doaj.org/article/f927a15129874784bfc8ae37ab73f56a
Autor:
Md. Enamul Kabir Talukder, Shahina Akhter, Foysal Ahammad, Asmim Aktar, Md. Saidul Islam, Aysha Akter Laboni, Mirola Afroze, Mala Khan, Mohammad Jashim Uddin, Md. Mashiar Rahman
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37178- (2024)
Argemone mexicana L. is a medicinal plant, but its impact on Alzheimer's disease (AD) is right now undetermined. We intended to investigate the in-vitro anti-AD potential of leaves and flowers of A. mexicana methanol, ethanol, and ethyl extracts and
Externí odkaz:
https://doaj.org/article/a13dc491c10e44cb9a19b79cc98a72e6
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Alzheimer’s disease (AD) is currently considered the major cause of cognitive impairment in older adults. This explains the close attention to the issue of AD research. The pathomorphological basis of the disease is a neurodegenerative process, the
Externí odkaz:
https://doaj.org/article/c2eda1848ea84405b6599dc5091c2d66
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
β-secretase 1, one of the most important proteins, is an aspartate protease. This membrane-associated protein is used for treating Alzheimer’s disease (AD). Several inhibitors have been pursued against β-secretase 1, but they still have not resul
Externí odkaz:
https://doaj.org/article/034131e897bc45a79b70c7a89e1a735f
Publikováno v:
Electronic Journal of Biotechnology, Vol 68, Iss , Pp 67-80 (2024)
Background: Alzheimer’s disease (AD) is the most common form of dementia and dementia constitutes the fifth leading cause of mortality across the globe. Available treatment modalities and drugs have abysmally failed to curtail AD. This study evalua
Externí odkaz:
https://doaj.org/article/861a9b6d874443bcb133ebc9294281fe
Autor:
Eduardo Suárez-González, Jesús Sandoval-Ramírez, Jorge Flores-Hernández, Alan Carrasco-Carballo
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 9674-9691 (2023)
Ginkgo biloba (GB) extracts have been used in clinical studies as an alternative therapy for Alzheimer’s disease (AD), but the exact bioaction mechanism has not yet been elucidated. In this work, an in silico study on GB metabolites was carried out
Externí odkaz:
https://doaj.org/article/e209a2a5dba942739044e3c4fa3e8151
Autor:
Takahiro Katsuki, Kayako Ogi, Ayaka Kinno, Shingo Kasamatsu, Hideshi Ihara, Hidenobu Sumitani
Publikováno v:
Foods, Vol 13, Iss 18, p 2858 (2024)
The number of people with dementia is increasing annually worldwide. Alzheimer’s disease (AD), which accounts for the highest percentage of dementia-causing diseases, remains difficult to cure, and prevention of its onset is important. We aimed to
Externí odkaz:
https://doaj.org/article/4aaec78a7b9e4e47a8fb62a66739d7cb