Výsledky vyhledávání - "živčani bojni otrovi"

Biokemijska analiza reaktivacije fosfilirane butirilkolinesteraze u ovisnosti o strukturi oksima

Autor: Čadež, Tena

Sposobnost butirilkolinesteraze (BChE) da vezanjem organofosfornih (OP) spojeva snižava njihovu koncentraciju u organizmu i time sprječava inhibiciju acetilkolinesteraze (AChE) predstavlja novi temelj terapije kod otrovanja ovim spojevima. Budući

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::dd497b2b0b4001b78c6034e82ace7ae3
https://www.bib.irb.hr/1260701

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Biochemical analysis of the reactivation of phosphylated butyrylcholinesterase in relation with the oxime structure

Autor: Čadež, Tena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3908::2ec6f889b383955f845980c6388bdb49
https://repozitorij.pmf.unizg.hr/islandora/object/pmf:11494/datastream/PDF

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Butyrylcholinesterase - steping out of acetylcholinesterase's shadow as pseudocatalytic bioscavenger of nerve agents

Autor: Čadež, Tena, Kovarik, Zrinka

In 1940s cholinesterases became interest of study because of their role in nerve transmission, but it was soon shown that butyrylcholinesterase (BChE) is not so important because even with complete absence of BChE subjects were still alive and health

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::c8452480c4f29c6e1a32a50b6c6cadf8
https://www.bib.irb.hr/1131998

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Sarin, VX, Novichok – zašto su još uvijek prijetnja?

Autor: Katalinić, Maja

Sarin, VX i Novichok su spojevi koji pripadaju skupini visokotoksičnih organofosfornih živčanih bojnih otrova. Razvoj, proizvodnja, nabava i skladištenje navedenih spojeva, kao i drugih iz skupine živčanih bojnih otrova, zabranjeni su međunaro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::4aad64e68347075ccc37803f9b430103
https://www.bib.irb.hr/977833

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Development of new chiral 2-hydroxyiminoacetamide reactivators of phosphylated cholinesterases

Autor: Maraković, Nikola

Korištenjem računalnih metoda molekulskog modeliranja proučavane su konformacijske promjene u aktivnom mjestu acetilkolinesteraze (AChE; EC 3.1.1.7) nakon vezanja raznih liganada te su definirane strukturne karakteristike učinkovitih oksimskih re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4a6d25a51497c86439ef00222d535d91
https://repozitorij.pmf.unizg.hr/islandora/object/pmf:1252/datastream/PDF

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Šaroliki svijet organofosfata

Autor: Maček Hrvat, Nikolina

Šaroliki svijet organofosfata je izvrstan primjer kako u jednoj skupini spojeva istovremeno možemo pronaći molekule koje »život znače«, molekule koje su korisne, ali i one koje su štetne i opasne za prirodu te smrtonosne za ljude. Zato je lju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::416eb042a2a839ac9d4bbaaea9aa9166
https://www.bib.irb.hr/920230

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Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning

Autor: Katalinić, Maja, Maček Hrvat, Nikolina, Ždarova Karasova, Jana, Misik, Jan, Kovarik, Zrinka

Publikováno v: Arhiv za higijenu rada i toksikologiju
Volume 66
Issue 4

Even if organophosphorus (OP) nerve agents were banned entirely, their presence would remain a problem as weapons of terror (like in Syria). Oxime antidotes currently used in medical practice still fall short of their therapeutic purpose, as they fai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::86c40a5aa8aa68d59a15cab67bd2d3a3
https://hrcak.srce.hr/149581

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Evaluation of Oxime K203 as Antidote in Tabun Poisoning

Autor: Kovarik, Zrinka, Lucić Vrdoljak, Ana, Berend, Suzana, Čalić, Maja, Kuča, Kamil, Musilek, Kamil, Radić, Božica

Publikováno v: Arhiv za higijenu rada i toksikologiju
Volume 60
Issue 1

We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyimino methylpyridinium)- but-2-ene dibromide] with tabun-inhibited human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro, and its antidotal effect on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::311f0dd76129203a6f3bc023ff03c5fe
https://hrcak.srce.hr/34843

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Structure-Activity Approach in the Reactivation of Tabun-Phosphorylated Human Acetylcholinesterase with Bispyridinium para-Aldoximes

Autor: Zrinka Kovarik, Maja Čalić, Goran Šinko, Anita Bosak

Publikováno v: Arhiv za higijenu rada i toksikologiju
Volume 58
Issue 2

We investigated interactions of bispyridinium para-aldoximes N,N’-(propano)bis(4-hydroxyiminomethyl) pyridinium bromide (TMB-4), N,N’-(ethano)bis(4-hydroxyiminomethyl)pyridinium methanosulphonate (DMB-4), and N,N’-(methano)bis(4-hydroxyiminomet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______951::15ed7e8270405885eb0d0760c8cca2f8
https://hrcak.srce.hr/12902

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Pyridinium Oximes: Rationale for Their Selection as Causal Antidotes Against Organophosphate Poisonings and Current Solutions for Auto-Injectors

Autor: Miloš P. Stojiljković, Milan Jokanović

Publikováno v: Arhiv za higijenu rada i toksikologiju
Volume 57
Issue 4

During the last five decades, five pyridinium oximes were found to be worthy of use as antidotes against nerve agents in humans: pralidoxime, in a form of chloride or PAM-2 Cl and mesylate or P2S (against sarin, cyclosarin and VX), trimedoxime or TMB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______951::afac68518c5bbb68df52959bd8bbe347
https://hrcak.srce.hr/file/9228

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