Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Žiga Urlep"'
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The liver is to date the best example of a sexually dimorphic non-reproductive organ. Over 1,000 genes are differentially expressed between sexes indicating that female and male livers are two metabolically distinct organs. The spectrum of liver dise
Externí odkaz:
https://doaj.org/article/5b120d8f2e884bfc8c4c931f5813a3c6
Autor:
Miha Mraz, Winnie Eskild, Žiga Urlep, Tadeja Režen, Damjana Rozman, Peter Juvan, Xiang Yi Kong, Kaja Blagotinšek Cokan, Miha Moškon
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 832, p 832 (2021)
Volume 22
Issue 2
International journal of molecular sciences, vol. 22, no. 2, 832, 2021.
International Journal of Molecular Sciences, Vol 22, Iss 832, p 832 (2021)
Volume 22
Issue 2
International journal of molecular sciences, vol. 22, no. 2, 832, 2021.
Multifactorial metabolic diseases, such as non-alcoholic fatty liver disease, are a major burden to modern societies, and frequently present with no clearly defined molecular biomarkers. Herein we used system medicine approaches to decipher signature
Autor:
Miha Moškon, Winnie Eskild, Damjana Rozman, Peter Juvan, Kaja Blagotinšek Cokan, Tadeja Režen, Miha Mraz, Žiga Urlep, Xiang Y. Kong
Multifactorial metabolic diseases, such as non-alcoholic fatty liver disease, are a major burden of modern societies and frequently present with no clearly defined molecular biomarkers. Herein we used systems medicine approaches to decipher signature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6f2c8f7293ba9bd492bafcaf5bfa6a9
https://doi.org/10.1101/2020.11.02.364901
https://doi.org/10.1101/2020.11.02.364901
Autor:
Damjana Rozman, Martina Perše, Kaja Blagotinšek Cokan, Cene Skubic, Gregor Lorbek, Peter Juvan, Tadeja Režen, Madlen Matz-Soja, Žiga Urlep, Jera Jeruc
Publikováno v:
Cancers, Vol 12, Iss 3302, p 3302 (2020)
Cancers
Cancers, vol. 12, no. 11, 3302, 2020.
Volume 12
Issue 11
Cancers
Cancers, vol. 12, no. 11, 3302, 2020.
Volume 12
Issue 11
While the role of cholesterol in liver carcinogenesis remains controversial, hepatocellular carcinoma generally prevails in males. Herein, we uncover pathways of female-prevalent progression to hepatocellular carcinoma due to chronic repression of ch
Autor:
Martina Perše, Cene Skubic, Damjana Rozman, Žiga Urlep, Peter Juvan, Kaja Blagotinšek Cokan, Tadeja Režen, Gregor Lorbek, Jera Jeruc, Madlen Matz-Soja
We uncover novel pathways of sex-dependent hepatocarcinogenesis due to chronic repression of cholesterol synthesis at the lanosterol 14α-demethylase (CYP51) step. The response to metabolic insult determined by global liver transcriptome, qPCR and st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8e71752bc5922d86cedd03fdc290ec0
https://doi.org/10.1101/2020.09.03.280974
https://doi.org/10.1101/2020.09.03.280974
Publikováno v:
Pharmacogenomics. 17:1273-1288
Nonalcoholic fatty liver disease (NAFLD) is a raising liver disease with increasing prevalence due to the epidemics of obesity and diabetes, with end points in cirrhosis or hepatocellular carcinoma. A multitude of genetic and metabolic perturbations,
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Frontiers in Physiology
Frontiers in Physiology
The liver is to date the best example of a sexually dimorphic non-reproductive organ. Over 1000 genes are differentially expressed between sexes indicating that female and male livers are two metabolically distinct organs. The spectrum of liver disea
Autor:
Michael P. Myers, Boštjan Matos, Ivana Jovčevska, Anton Buzdin, Neja Zupanec, Radovan Komel, Žiga Urlep, Andrej Vranič, Serge Muyldermans, Clara Limbaeck Stokin, Ivan Petrov
Publikováno v:
Oncotarget
// Ivana Jovcevska 1 , Neja Zupanec 1 , Žiga Urlep 2 , Andrej Vranic 3 , Bostjan Matos 4 , Clara Limbaeck Stokin 5 , Serge Muyldermans 6 , Michael P. Myers 7 , Anton A. Buzdin 8, 9 , Ivan Petrov 10, 11 and Radovan Komel 1 1 Medical Center for Molecu
Autor:
Rolf Gebhardt, Dan R. Littman, Martina Perše, Ingemar Björkhem, Gregor Lorbek, Damjana Rozman, Peter Juvan, Jason A. Hall, Richard Bonneau, Žiga Urlep, Madlen Matz-Soja, Jera Jeruc
Publikováno v:
Scientific Reports
Development of mice with hepatocyte knockout of lanosterol 14α-demethylase (HCyp51−/−) from cholesterol synthesis is characterized by the progressive onset of liver injury with ductular reaction and fibrosis. These changes begin during puberty a
Autor:
Marko Goličnik, Jure Acimovic, Rok Košir, Žiga Urlep, Martina Perše, Aleš Belič, Damjana Rozman, F. Peter Guengerich, Sandeep Goyal
Publikováno v:
Scientific Reports
Cholesterol synthesis is among the oldest metabolic pathways, consisting of the Bloch and Kandutch-Russell branches. Following lanosterol, sterols of both branches are proposed to be dedicated to cholesterol. We challenge this dogma by mathematical m