Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents

Autor: Waszkielewicz, A.M., Gunia-Krzyżak, A., Powroźnik, B., Słoczyńska, K., Pękala, E., Walczak, M., Bednarski, M., Żesławska, E., Nitek, W., Marona, H.

Publikováno v: In Bioorganic & Medicinal Chemistry 15 April 2016 24(8):1793-1810

Promising anticonvulsant and/or analgesic compounds among 5-chloro-2- or 5-chloro-4-methyl derivatives of xanthone coupled to aminoalkanol moieties-Design, synthesis and pharmacological evaluation.

Autor: Mazur G; Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Pańczyk-Straszak K; Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Rapacz A; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Kiszela J; Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Smolik M; Chair and Department of Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Gawlik M; Chair and Department of Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Walczak M; Chair and Department of Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Czekajewska J; Department of Microbiology, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Poloczek C; Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Karczewska E; Department of Microbiology, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Żesławska E; Institute of Biology, Pedagogical University of Krakow, Kraków, Poland., Nitek W; Department of Crystallochemistry and Crystallophysics, Faculty of Chemistry, Jagiellonian University, Kraków, Poland., Niedbał A; Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Leśniak J; Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland., Ciapala K; Department of Pain Pharmacology, Maj Institute of Pharmacology, Kraków, Poland., Pawlik K; Department of Pain Pharmacology, Maj Institute of Pharmacology, Kraków, Poland., Mika J; Department of Pain Pharmacology, Maj Institute of Pharmacology, Kraków, Poland., Waszkielewicz AM; Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.

Publikováno v: Chemical biology & drug design [Chem Biol Drug Des] 2023 Feb; Vol. 101 (2), pp. 278-325. Date of Electronic Publication: 2022 Dec 16.

Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT 6 R agents.

Autor: Sudoł-Tałaj S; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, Św. Łazarza 16, PL 31-530, Kraków, Poland., Kucwaj-Brysz K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Podlewska S; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, Smętna 12, PL 31-343, Kraków, Poland., Kurczab R; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, Smętna 12, PL 31-343, Kraków, Poland., Satała G; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, Smętna 12, PL 31-343, Kraków, Poland., Mordyl B; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Głuch-Lutwin M; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Wilczyńska-Zawal N; Department of Clinical Pharmacy, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Jastrzębska-Więsek M; Department of Clinical Pharmacy, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Czarnota-Łydka K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, Św. Łazarza 16, PL 31-530, Kraków, Poland., Kurowska K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Kubacka M; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Żesławska E; Institute of Biology and Earth Sciences, Pedagogical University of Krakow, Podchorążych 2, PL 30-084, Kraków, Poland., Nitek W; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, PL 30-387, Kraków, Poland., Olejarz-Maciej A; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Doroz-Płonka A; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Partyka A; Department of Clinical Pharmacy, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Latacz G; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Wesołowska A; Department of Clinical Pharmacy, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland., Handzlik J; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Kraków, Poland. Electronic address: j.handzlik@uj.edu.pl.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Nov 15; Vol. 260, pp. 115756. Date of Electronic Publication: 2023 Aug 24.

Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT 6 R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.

Autor: Czarnota-Łydka K; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, św. Łazarza 15, 31-530, Krakow, Poland. Electronic address: kinga.czarnota@doctoral.uj.edu.pl., Sudoł-Tałaj S; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, św. Łazarza 15, 31-530, Krakow, Poland. Electronic address: s.sudol@doctoral.uj.edu.pl., Kucwaj-Brysz K; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: katarzyna.kucwaj@uj.edu.pl., Kurczab R; Maj Institute of Pharmacology Polish Academy of Sciences, Department of Medicinal Chemistry, Smętna 12, PL 31-343, Krakow, Poland. Electronic address: kurczab@if-pan.krakow.pl., Satała G; Maj Institute of Pharmacology Polish Academy of Sciences, Department of Medicinal Chemistry, Smętna 12, PL 31-343, Krakow, Poland. Electronic address: satala@if-pan.krakow.pl., de Candia M; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: modesto.decandia@uniba.it., Samarelli F; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: francesco.samarelli@uniba.it., Altomare CD; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: cosimodamiano.altomare@uniba.it., Carocci A; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: alessia.carocci@uniba.it., Barbarossa A; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: alexia.barbarossa@uniba.it., Żesławska E; Pedagogical University of Krakow, Institute of Biology and Earth Sciences, Podchorążych 2, PL 30-084, Krakow, Poland. Electronic address: ewa.zeslawska@up.krakow.pl., Głuch-Lutwin M; Department of Pharmacobiology, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: monika.gluch-lutwin@uj.edu.pl., Mordyl B; Department of Pharmacobiology, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: barbara.mordyl@uj.edu.pl., Kubacka M; Department of Pharmacodynamics, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: monika.kubacka@uj.edu.pl., Wilczyńska-Zawal N; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: natalia.wilczynska@uj.edu.pl., Jastrzębska-Więsek M; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: m.jastrzebska-wiesek@uj.edu.pl., Partyka A; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: annairena.partyka@uj.edu.pl., Khan N; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, św. Łazarza 15, 31-530, Krakow, Poland; Department of Pathophysiology, Jagiellonian University, Medical College, Czysta 18, PL 30-688, Krakow, Poland. Electronic address: nadia.khan@doctoral.uj.edu.pl., Więcek M; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: malgorzata.wiecek@uj.edu.pl., Nitek W; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, PL 30-387, Krakow, Poland. Electronic address: wojciech.nitek@uj.edu.pl., Honkisz-Orzechowska E; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: ewelina.honkisz@uj.edu.pl., Latacz G; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: gniewomir.latacz@uj.edu.pl., Wesołowska A; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: a.wesolowska@uj.edu.pl., Carrieri A; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: antonio.carrieri@uniba.it., Handzlik J; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: j.handzlik@uj.edu.pl.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Nov 05; Vol. 259, pp. 115695. Date of Electronic Publication: 2023 Jul 30.

New Triazine Derivatives as Serotonin 5-HT 6 Receptor Ligands.

Autor: Łażewska D; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland., Więcek M; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland., Satała G; Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland., Chałupnik P; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland., Żesławska E; Institute of Biology, Pedagogical University of Krakow, Podchorążych 2, 30-084 Kraków, Poland., Honkisz-Orzechowska E; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland., Tarasek M; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland., Latacz G; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland., Nitek W; Faculty of Chemistry, Jagiellonian University in Kraków, Gronostajowa 2, 30-387 Kraków, Poland., Szymańska E; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland., Handzlik J; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 22; Vol. 28 (3). Date of Electronic Publication: 2023 Jan 22.