Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Štefan Bezek"'
Publikováno v:
Neurotoxicity Research. 36:844-858
The ROS-mediated lysosomal dysfunction and coinciding deterioration of mitochondrial function are thought to be the prominent mechanisms responsible for aging. Microglia, the resident macrophages in the central nervous system, were postulated to belo
Autor:
Çimen Karasu, Karol Svik, Lucia Kovacikova, Štefan Bezek, Marta Soltesova Prnova, Milan Stefek
Publikováno v:
Neurochemical Research. 44:1056-1064
Peripheral neuropathy is the most prevalent chronic complication of diabetes mellitus. Good glycemic control can delay the appearance of neuropathic symptoms in diabetic patients but it is not sufficient to prevent or cure the disease. Therefore ther
Autor:
Ružena Sotníková, B. Tyukos Kaprinay, Štefan Bezek, L. Slovák, D. Micháliková, Karol Svik, Boris Lipták, Zdenka Gasparova
Publikováno v:
European Pharmaceutical Journal, Vol 65, Iss 2, Pp 12-16 (2018)
The aim of this study was to determine pharmacological possibilities of influencing the risk factors of metabolic syndrome (MetS). Hypertriacylglycerolemic (HTG) rats fed with high-fat-fructose diet (HFFD) were used as a model of the MetS. Wistar rat
Publikováno v:
Free radical biologymedicine. 152
During brain ageing, microglia, the resident immune cells of the CNS, are immunologically activated and contribute to neuroinflammation, a vicious cycle that supports development of neurological disorders. Therapeutic approaches focus mainly on downr
Autor:
Stankovicová T, Zuzana Brnoliakova, Štefan Bezek, Viktor Bauer, Vladimir Knezl, Ružena Sotníková
Publikováno v:
Interdisciplinary Toxicology, Vol 10, Iss 3, Pp 86-92 (2017)
Interdisciplinary Toxicology
Interdisciplinary Toxicology
Metabolic syndrome belongs to the most important risk factors of cardiovascular diseases. The aim of this study was to investigate changes in cardiovascular system induced by high cholesterol and high fat diet (HCHF) in HTG rats and their influence b
Autor:
Ružena Sotníková, Zuzana Brnoliakova, Ema Paulovičová, Štefan Bezek, Jana Navarová, Viktor Bauer, Vladimir Knezl
Publikováno v:
Interdisciplinary Toxicology, Vol 10, Iss 3, Pp 81-85 (2017)
Interdisciplinary Toxicology
Interdisciplinary Toxicology
Elevated plasma cholesterol, especially low density lipoprotein (LDL) cholesterol, is one of the major risk factors for atherosclerosis and coronary heart disease. Hereditary hypertriglyceridemic rats (hHTG) were developed as a new inbred model for t
Autor:
Zubeyir Elmazoglu, Lucia Kovacikova, Karol Svik, Štefan Bezek, Milan Stefek, Çimen Karasu, Marta Soltesova Prnova
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 393(4)
Hyperglycemia is considered a key risk factor for development of diabetic complications including neuropathy. There is strong scientific evidence showing a primary role of aldose reductase, the first enzyme of the polyol pathway, in the cascade of me
Autor:
Karol Svik, Marta Soltesova Prnova, Çimen Karasu, Lucia Kovacikova, Štefan Bezek, Milan Stefek
Publikováno v:
Pathophysiology. 25:217-218
Autor:
Natália Sedláčková, Ivan Padej, Lucia Račková, Nataša Mrvová, Mojmír Mach, Martin Škandík, Zdenka Gasparova, Dominika Luptáková, Štefan Bezek
Publikováno v:
Interdisciplinary Toxicology
Interdisciplinary Toxicology, Vol 10, Iss 1, Pp 11-19 (2017)
Interdisciplinary Toxicology, Vol 10, Iss 1, Pp 11-19 (2017)
Synthetic pyridoindole-type substances derived from the lead compound stobadine represent promising agents in treatment of a range of pathologies including neurological disorders. The beneficial biological effects were suggested to be likely associat
Autor:
Norbert Vrbjar, Jana Vlkovicova, Z Kyselova, Štefan Bezek, Lucia Mézešová, Veronika Jendruchová-Javorková, Jana Navarová
Publikováno v:
Molecular and Cellular Biochemistry. 366:41-48
The study was focused to the influence of higher intake of cholesterol on properties of the renal Na,K-ATPase, a key system in maintaining the homeostasis of sodium in the organism. Feeding for 4 weeks with cholesterol-enriched food for rats afflicte