IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives

Autor: Španko, Michal, Strnadová, Karolína, Pavlíček, Aleš Jan, Szabo, Pavol, Kodet, Ondřej, Valach, Jaroslav, Dvořánková, Barbora, Smetana, Karel, Lacina, Lukáš

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11027, p 11027 (2021)
International Journal of Molecular Sciences

Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::94e9a51a964f141b1844a5373aa68161
https://www.mdpi.com/1422-0067/22/20/11027

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Desmoplastic Crosstalk in Pancreatic Ductal Adenocarcinoma Is Reflected by Different Responses of Panc-1, MIAPaCa-2, PaTu-8902, and CAPAN-2 Cell Lines to Cancer-associated/Normal Fibroblasts.

Autor: Novák Š; Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic.; Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic., Kolář M; Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Szabó A; Department of Pathology, Third Faculty of Medicine, Charles University and University Hospital Královske Vinohrady, Prague, Czech Republic., Vernerová Z; Department of Pathology, Third Faculty of Medicine, Charles University and University Hospital Královske Vinohrady, Prague, Czech Republic., Lacina L; Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic.; BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic.; Department of Dermatology and Venereology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic., Strnad H; Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Šáchová J; Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Hradilová M; Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Havránek J; Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.; Department of Informatics and Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, Prague, Czech Republic., Španko M; Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic.; Department of Stomatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic., Čoma M; Department of Pharmacology, Pavol Jozef Šafárik University, Košice, Slovak Republic.; Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Košice, Slovak Republic., Urban L; Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Košice, Slovak Republic.; Laboratory of Cell Interactions, Center of Clinical and Preclinical Research MediPark, Pavol Jozef Šafárik University, Košice, Slovak Republic., Kaňuchová M; Laboratory of Cell Interactions, Center of Clinical and Preclinical Research MediPark, Pavol Jozef Šafárik University, Košice, Slovak Republic., Melegová N; Laboratory of Cell Interactions, Center of Clinical and Preclinical Research MediPark, Pavol Jozef Šafárik University, Košice, Slovak Republic., Gürlich R; Department of Surgery, Third Faculty of Medicine, Charles University and University Hospital Královske Vinohrady, Prague, Czech Republic., Dvořák J; Department of Oncology, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic., Smetana K Jr; Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic.; BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic., Gál P; Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Košice, Slovak Republic; pavol.szabo@lf1.cuni.cz pgal@vusch.sk galovci@yahoo.com.; Laboratory of Cell Interactions, Center of Clinical and Preclinical Research MediPark, Pavol Jozef Šafárik University, Košice, Slovak Republic.; Prague Burn Centre, Third Faculty of Medicine, Charles University and University Hospital Královske Vinohrady, Prague, Czech Republic., Szabo P; Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic; pavol.szabo@lf1.cuni.cz pgal@vusch.sk galovci@yahoo.com.; BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic.; Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Košice, Slovak Republic.

Publikováno v: Cancer genomics & proteomics [Cancer Genomics Proteomics] 2021 May-Jun; Vol. 18 (3), pp. 221-243.