Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Šárka Štěpánková"'
Autor:
Neto-Honorius Houngbedji, Šárka Štěpánková, Václav Pflégr, Katarína Svrčková, Markéta Švarcová, Jarmila Vinšová, Martin Krátký
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 172 (2023)
On the basis of previous reports, novel 2-benzoylhydrazine-1-carboxamides were designed as potential inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Inhibitors of these enzymes have many clinical applications. 2-(Substitut
Externí odkaz:
https://doaj.org/article/765f957263a74e0280aa81923c999a84
Autor:
Václav Pflégr, Šárka Štěpánková, Katarína Svrčková, Markéta Švarcová, Jarmila Vinšová, Martin Krátký
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 400 (2022)
2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthe
Externí odkaz:
https://doaj.org/article/38ecdfbecb5d41db82182a3502ac2718
Autor:
Martin Krátký, Šárka Štěpánková, Klára Konečná, Katarína Svrčková, Jana Maixnerová, Markéta Švarcová, Ondřej Janďourek, František Trejtnar, Jarmila Vinšová
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1229 (2021)
A series of thirty-one hydrazones of aminoguanidine, nitroaminoguanidine, 1,3-diaminoguanidine, and (thio)semicarbazide were prepared from various aldehydes, mainly chlorobenzaldehydes, halogenated salicylaldehydes, 5-nitrofurfural, and isatin (yield
Externí odkaz:
https://doaj.org/article/fcac6a015aab4e599dcb6c73d4149617
Autor:
Pratibha Magar, Oscar Parravicini, Šárka Štěpánková, Katarina Svrčková, Adriana D. Garro, Izabela Jendrzejewska, Karel Pauk, Jan Hošek, Josef Jampílek, Ricardo D. Enriz, Aleš Imramovský
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9447 (2021)
A series of 14 target benzyl [2-(arylsulfamoyl)-1-substituted-ethyl]carbamates was prepared by multi-step synthesis and characterized. All the final compounds were tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinester
Externí odkaz:
https://doaj.org/article/aef292e3ee0341f19459eb0ce4ca8b4e
Publikováno v:
Molecules, Vol 26, Iss 4, p 989 (2021)
Based on the broad spectrum of biological activity of hydrazide–hydrazones, trifluoromethyl compounds, and clinical usage of cholinesterase inhibitors, we investigated hydrazones obtained from 4-(trifluoromethyl)benzohydrazide and various benzaldeh
Externí odkaz:
https://doaj.org/article/279c19a6ab754560a19480f1e7bf4271
Autor:
Martin Krátký, Zsuzsa Baranyai, Šárka Štěpánková, Katarína Svrčková, Markéta Švarcová, Jiřina Stolaříková, Lilla Horváth, Szilvia Bősze, Jarmila Vinšová
Publikováno v:
Molecules, Vol 25, Iss 10, p 2268 (2020)
Based on the isosterism concept, we have designed and synthesized homologous N-alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides (from C1 to C18) as potential antimicrobial agents and enzyme inhibitors. They were obtained from 4-(trifluoro
Externí odkaz:
https://doaj.org/article/3c6d6b176c1346e4b2467b3b3616f90b
Autor:
Jarmila Vinšová, Martin Krátký, Markéta Komlóová, Echchukattula Dadapeer, Šárka Štěpánková, Katarína Vorčáková, Jiřina Stolaříková
Publikováno v:
Molecules, Vol 19, Iss 6, Pp 7152-7168 (2014)
A new series of 27 diethyl 2-(phenylcarbamoyl)phenyl phosphorothioates (thiophosphates) was synthesized, characterized by NMR, IR and CHN analyses and evaluated against Mycobacterium tuberculosis H37Rv, Mycobacterium avium and two strains of Mycobact
Externí odkaz:
https://doaj.org/article/61e6a30b8749480ba20de41b367501d3
2-Hydroxy-N-phenylbenzamides and Their Esters Inhibit Acetylcholinesterase and Butyrylcholinesterase
Autor:
Martin Krátký, Šárka Štěpánková, Neto-Honorius Houngbedji, Rudolf Vosátka, Katarína Vorčáková, Jarmila Vinšová
Publikováno v:
Biomolecules, Vol 9, Iss 11, p 698 (2019)
The development of novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) represents a viable approach to alleviate Alzheimer’s disease. Thirty-six halogenated 2-hydroxy-N-phenylbenzamides (salicylanilides) with various s
Externí odkaz:
https://doaj.org/article/827e22d74bb147fc85350ec30870a88a
Autor:
Jakub Chlebek, Jan Korábečný, Rafael Doležal, Šárka Štěpánková, Daniel I. Pérez, Anna Hošťálková, Lubomír Opletal, Lucie Cahlíková, Kateřina Macáková, Tomáš Kučera, Martina Hrabinová, Daniel Jun
Publikováno v:
Molecules, Vol 24, Iss 7, p 1340 (2019)
In recent studies, several alkaloids acting as cholinesterase inhibitors were isolated from Corydalis cava (Papaveraceae). Inhibitory activities of (+)-thalictricavine (1) and (+)-canadine (2) on human acetylcholinesterase (hAChE) and butyrylcholines
Externí odkaz:
https://doaj.org/article/4222d098d41c4d2aa46c3ac96c25eacb
Publikováno v:
Molecules, Vol 21, Iss 2, p 191 (2016)
Based on the presence of carbamoyl moiety, twenty salicylanilide N,N-disubstituted (thio)carbamates were investigated using Ellman’s method for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). O-Aromatic (thio)
Externí odkaz:
https://doaj.org/article/1c358195046647c3a0b097c55cdc60a2