Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Šárka Šimečková"'
Autor:
Hana Paculová, Juraj Kramara, Šárka Šimečková, Radek Fedr, Karel Souček, Ondřej Hylse, Kamil Paruch, Marek Svoboda, Martin Mistrík, Jiří Kohoutek
Publikováno v:
Tumor Biology, Vol 39 (2017)
A broad spectrum of tumors develop resistance to classic chemotherapy, necessitating the discovery of new therapies. One successful strategy exploits the synthetic lethality between poly(ADP-ribose) polymerase 1/2 proteins and DNA damage response gen
Externí odkaz:
https://doaj.org/article/e7bcbdc4ad754e1e8d403ed31b65297e
Publikováno v:
Cytometry Part A. 93:239-248
Complex analysis of cellular responses after experimental treatment is important for screening, mechanistic understanding of treatment effects, and the identification of sensitive and resistant cell phenotypes. Modern multicolor flow cytometry has de
Autor:
Vladimír Študent, Zuzana Kahounová, Jan Bouchal, Alois Kozubík, Karel Souček, Gvantsa Kharaishvili, Ján Remšík, Daniela Kurfürstová, Šárka Šimečková, Jiří Navrátil
Publikováno v:
Cytometry Part A. 93:941-951
The identification of fibroblasts and cancer-associated fibroblasts from human cancer tissue using surface markers is difficult, especially because the markers used currently are usually not expressed solely by fibroblasts, and the identification of
Autor:
Zuzana Kahounová, Petr Beneš, Ján Remšík, Jiřina Procházková, Jan Bouchal, Tereza Suchankova, Gvantsa Kharaishvili, Karel Souček, Milan Král, Radek Fedr, Eva Slabáková, Šárka Šimečková
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Skp2 is a crucial component of SCFSkp2 E3 ubiquitin ligase and is often overexpressed in various types of cancer, including prostate cancer (PCa). The epithelial-to-mesenchymal transition (EMT) is involved in PCa progression. The acquisition of a mes
Autor:
Sára Lenárt, Šárka Šimečková, Radek Fedr, Zuzana Kahounová, Jan Bouchal, Petr Beneš, Gvantsa Kharaishvili, Lucia Binó, Eva Slabáková, Milan Král, Tereza Kučírková, Ján Remšík, Lucia Knopfová, Karel Souček, Ximena Maria Muresan
Publikováno v:
Carcinogenesis. 39(11)
The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype i
Autor:
Martin Mistrik, Radek Fedr, Ondřej Hylse, Jiří Kohoutek, Šárka Šimečková, Kamil Paruch, Juraj Kramara, Hana Paculová, Karel Souček, Marek Svoboda
Publikováno v:
Tumor Biology, Vol 39 (2017)
A broad spectrum of tumors develop resistance to classic chemotherapy, necessitating the discovery of new therapies. One successful strategy exploits the synthetic lethality between poly(ADP-ribose) polymerase 1/2 proteins and DNA damage response gen
Autor:
Šárka Šimečková, Radek Fedr, Ján Remšík, Lucia Binó, Alois Kozubík, Zuzana Pernicová, Eva Slabáková, Karel Souček
Publikováno v:
Endocrine Abstracts.
Autor:
Zuzana, Kahounová, Daniela, Kurfürstová, Jan, Bouchal, Gvantsa, Kharaishvili, Jiří, Navrátil, Ján, Remšík, Šárka, Šimečková, Vladimír, Študent, Alois, Kozubík, Karel, Souček
Publikováno v:
Cytometry. Part A : the journal of the International Society for Analytical Cytology. 93(9)
The identification of fibroblasts and cancer-associated fibroblasts from human cancer tissue using surface markers is difficult, especially because the markers used currently are usually not expressed solely by fibroblasts, and the identification of
Autor:
Lucia Knopfová, Eva Slabáková, Jan Bouchal, Ján Remšík, Gvantsa Kharaishvili, Petr Beneš, Lucia Binó, Tereza Nehybová, Radek Fedr, Šárka Šimečková, Karel Souček, Milan Král, Zuzana Kahounová
Publikováno v:
Cancer Research. 78:B084-B084
Dissemination of cancer cells to distant organs has fatal consequences to most of the patients with malignant tumors. Patients with prostate and breast cancer show apparent overlap of the most common sites of cancer metastasis, suggesting that breast
Autor:
Milan Král, Gvantsa Kharaishvili, Josef Jaroš, Šárka Šimečková, Alois Kozubík, Radek Fedr, Jan Bouchal, Tereza Suchankova, Karel Souček, Zuzana Pernicová, Eva Slabáková
Publikováno v:
Molecular Cancer
Background Tumor heterogeneity and the plasticity of cancer cells present challenges for effective clinical diagnosis and therapy. Such challenges are epitomized by neuroendocrine transdifferentiation (NED) and the emergence of neuroendocrine-like ca