Výsledky vyhledávání - "Ş Güniz, Küçükgüzel"

Synthesis, antimicrobial properties and in silico studies of aryloxyacetic acid derivatives with hydrazone or thiazolidine-4-one scaffold

Autor: Sevil Şenkardeş, Didem Kart, Bilge Bebek, Miyase Gözde Gündüz, Ş Güniz Küçükgüzel

Publikováno v: Journal of Biomolecular Structure and Dynamics. :1-12

In this work, twenty hydrazide-hydrazone and 4-thiazolidinone derivatives were synthesized starting from m-cresol. Antimicrobial evaluation was carried out by microdilution method against Enterococcus faecalis and Staphylococcus aureus as Gram-positi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfe6d63240ddd4ecfd436b8432c6037
https://doi.org/10.1080/07391102.2022.2121761

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Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers

Autor: Ozlem Bingol Ozakpinar, M. İhsan Han, Merve Gürboğa, Sevil Şenkardeş, Ş. Güniz Küçükgüzel

Publikováno v: Medicinal Chemistry Research. 31:368-379

In the present study, the various 28 hybrid molecules containing hydrazone and sulfonate moiety were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy and LC-MS spectrometry, besides elemental analysis. The compounds were evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec213941953243000ea8023790ea9552
https://doi.org/10.1007/s00044-021-02837-z

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Design, synthesis, and in vitro and in vivo anticancer activity studies of new (S)-Naproxen thiosemicarbazide/1,2,4-triazole derivatives

Autor: M.İhsan Han, Cansu Ümran Tunç, Pınar Atalay, Ömer Erdoğan, Gökhan Ünal, Mehmet Bozkurt, Ömer Aydın, Özge Çevik, Ş. Güniz Küçükgüzel

Publikováno v: New Journal of Chemistry. 46:6046-6059

© 2022 The Royal Society of ChemistryIn this study, a series of novel (S)-Naproxen derivatives bearing a thiosemicarbazide/1,2,4-triazole moiety were designed, synthesized, and evaluated for anticancer activity. The structures of these compounds wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cdc5afc08fd7a874253052da4278be
https://doi.org/10.1039/d1nj05899a

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A Novel PEtOx Based Nanogel For Selective Drug Release Targeting Prostate Cancer Cells

Autor: Sevgi Gülyüz, Melike Sessevmez, Gokcen Ukuser, Melek Parlak Khalily, Selen Tiryaki, Tarik Sipahioglu, Kaan Birgül, Salih Özçubukçu, Dilek Telci, Ş. Güniz Küçükgüzel, Mahmut Durmus, Erdal Cevher, Ozgur Yilmaz

In this study, prostate cancer-targeted, drug-loaded PEtOx nanogel was prepared by the combination of living/cationic ring-opening polymerization and alkyne-azide cycloaddition “click” chemistry. A fluorescence probe was also conjugated with nano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc9821e4901ab7408cd7c85f181a0f00
https://doi.org/10.21203/rs.3.rs-2489117/v1

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Synthesis and biological evaluation of novel aryloxyacetic acid hydrazide derivatives as anticancer agents

Autor: Ş. Güniz Küçükgüzel, Ömer Erdoğan, Ozge Cevik, Sevil Şenkardeş

Publikováno v: Synthetic Communications. 51:2634-2643

In our continuing search for new anticancer agents, herein we report the synthesis of 2-(4-chloro-3-methylphenoxy)-N'-[(aryl)methylidene]acetohydrazides 3a–j and the evaluation of their anticancer ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee90775286eb522ab8c733426e657584
https://doi.org/10.1080/00397911.2021.1945105

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Akademický článek

Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines

Autor: Sevgi Koçyiğit Sevinç, Oya Orun, Pınar Mega Tiber, Pelin Çıkla-Süzgün, Ş. Güniz Küçükgüzel

Publikováno v: Proceedings, Vol 2, Iss 25, p 1573 (2018)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as anti-inflammatory and analgesic agents. This family of drugs suppresses prostaglandin synthesis through inhibition of cyclooxygenase (COX) enzymes. Recent studies showed that anti-car

Externí odkaz: https://doaj.org/article/b77fa821a1d04c118c7d49a6fcb558a7

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Molecular modelling studies to suggest novel scaffolds against SARS-CoV-2 target enzymes

Autor: Ahmet Fatih Şahin, Ş. Güniz Küçükgüzel, Atilla Akdemir

Publikováno v: Journal of Research in Pharmacy. 25:1110-1117

In this study, molecular modelling study of previously synthesized compounds against SARS-CoV-2 target enzyme was performed. A subset of 156 compounds from an in-house database has been subjected to molecular modelling studies against the SARS-CoV-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac88729f14d19a7c636e2e92b052a6a2
https://doi.org/10.29228/jrp.96

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Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents

Autor: Kübra Kale, Merve Eylul Kiymaci, İsa Murat Kozanoğlu, Ş. Güniz Küçükgüzel, Sevil Şenkardeş, Banu Kaskatepe

Publikováno v: Journal of Research in Pharmacy. 25:135-141

In this study, some N'-(substituted arylmethylidene)-4-nitrobenzenesulfonohydrazide derivatives were synthesis by reading various aldehydes and 4-nitrobenzenesulfonohydrazide. The structural characterization of the compounds was performed by IR, H-1-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb330db73d5436b977e2538adea2d2e
https://doi.org/10.29228/jrp.4

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