Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Łukasz Witucki"'
Autor:
Łukasz Witucki, Hieronim Jakubowski
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Nutritional and genetic deficiencies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of atherosclerosis, which is a major cause of cardiovascular disease (CVD). Impaired auto
Externí odkaz:
https://doaj.org/article/d0b22d3492244cb8821495c45a419fed
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Hyperhomocysteinemia (HHcy), characterized by elevated homocysteine (Hcy) levels, is a known risk factor for cardiovascular, renal, and neurological diseases, as well as pregnancy complications. Our study aimed to investigate whether HHcy induced by
Externí odkaz:
https://doaj.org/article/c05efc88bd9e4d8a8247166223269762
Autor:
Łukasz Witucki, Hieronim Jakubowski
Publikováno v:
Cells, Vol 12, Iss 5, p 746 (2023)
Paraoxonase 1 (PON1), a homocysteine (Hcy)-thiolactone detoxifying enzyme, has been associated with Alzheimer’s disease (AD), suggesting that PON1 plays an important protective role in the brain. To study the involvement of PON1 in the development
Externí odkaz:
https://doaj.org/article/a1e95b9947ab43bf88325fa0a0f943c6
Publikováno v:
Medical Sciences Forum, Vol 8, Iss 1, p 5 (2022)
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor dysfunction associated with a loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies, mainly composed of ag
Externí odkaz:
https://doaj.org/article/e189e7f53c1c43799d46881b57592c64
Autor:
Łukasz Witucki, Monika Kurpik, Hieronim Jakubowski, Michał Szulc, Przemysław Łukasz Mikołajczak, Jadwiga Jodynis-Liebert, Małgorzata Kujawska
Publikováno v:
Nutrients, Vol 14, Iss 10, p 2014 (2022)
Rich in polyphenols, cranberry juice (CJ) with high antioxidant activity is believed to contribute to various health benefits. However, our knowledge of the neuroprotective potential of cranberries is limited. Previously, we have demonstrated that CJ
Externí odkaz:
https://doaj.org/article/10077536cd574a70b0c60255e6c3986b
Autor:
Małgorzata Kujawska, Michael Jourdes, Łukasz Witucki, Marta Karaźniewicz-Łada, Michał Szulc, Agata Górska, Przemysław Ł. Mikołajczak, Pierre-Louis Teissedre, Jadwiga Jodynis-Liebert
Publikováno v:
Brain Sciences, Vol 11, Iss 9, p 1127 (2021)
Pomegranate juice (PJ) is a rich source of ellagitannins (ETs), precursors of colonic metabolite urolithin A, which are believed to contribute to pomegranate’s neuroprotective effect. While many experimental studies involving PJ’s role in Alzheim
Externí odkaz:
https://doaj.org/article/4c62298e44f64d4da7dcd31c1b7fd72a
Autor:
Małgorzata Kujawska, Łukasz Witucki, Marta Karaźniewicz-Łada, Michał Szulc, Agata Górska, Jadwiga Jodynis-Liebert
Publikováno v:
Medical Sciences Forum, Vol 8, Iss 1, p 4 (2021)
Pomegranate juice (PJ) is a rich source of ellagitannins, precursors of the colonic metabolite urolithin A believed to contribute to pomegranate’s neuroprotective effect. While many experimental studies involving PJ’s role in Alzheimer’s diseas
Externí odkaz:
https://doaj.org/article/f3909bea00ec411ca6f716d7778b5ace
Autor:
Łukasz Witucki, Hieronim Jakubowski
The loss of cystathionine β-synthase (CBS), an important homocysteine (Hcy)-metabolizing enzyme or the loss of PHF8, an important histone demethylase participating in epigenetic regulation, causes severe mental retardation in humans. Similar neuropa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0a7cfe06e9b7598c1d6a01e0856fc2a
https://doi.org/10.1101/2023.03.22.533769
https://doi.org/10.1101/2023.03.22.533769
Autor:
Łukasz Witucki, Kamila Borowczyk, Joanna Suszyńska-Zajczyk, Ewelina Warzych, Piotr Pawlak, Hieronim Jakubowski
Bleomycin hydrolase (BLMH), a homocysteine (Hcy)-thiolactone detoxifying enzyme, is attenuated in brains of Alzheimer’s disease patients. In mice, Blmh depletion causes astrogliosis and behavioral changes. Depletion of histone demethylase PHF8, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe5b7697971e124fd3c32a25014e7ce
https://doi.org/10.1101/2023.03.20.533511
https://doi.org/10.1101/2023.03.20.533511
Autor:
Hieronim Jakubowski, Łukasz Witucki
Publikováno v:
Cells
Volume 12
Issue 5
Pages: 746
Volume 12
Issue 5
Pages: 746
Paraoxonase 1 (PON1), a homocysteine (Hcy)-thiolactone detoxifying enzyme, has been associated with Alzheimer’s disease (AD), suggesting that PON1 plays an important protective role in the brain. To study the involvement of PON1 in the development