Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Łukasz Winiarski"'
Autor:
Łukasz Winiarski, Józef Oleksyszyn, Agnieszka Chryplewicz, Marcin Sieńczyk, Sandra Olewińska, Maciej A. Walczak, Mateusz Psurski, Karolina Torzyk
Publikováno v:
Chemistrybiodiversity. 18(2)
Acylpeptide hydrolase is a serine protease, which, together with prolyl oligopeptidase, dipeptidyl peptidase IV and oligopeptidase B, belongs to the prolyl oligopeptidase family. Its primary function is associated with the removal of N-acetylated ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42b18161d49f0262c6e198f4d023705
https://pubmed.ncbi.nlm.nih.gov/33427376
https://pubmed.ncbi.nlm.nih.gov/33427376
Autor:
Kamila Sychowska, Łukasz Winiarski, Mirosław Jarząb, Marcin Skoreński, Mateusz Psurski, Przemyslaw Glaza, Marcin Sieńczyk, Adam Lesner, Artur Giełdoń, Barbara Lipinska, Tomasz Wenta, Natalia Gruba, Magdalena Wysocka, Joanna Makowska, Joanna Zdancewicz
Publikováno v:
ACS Combinatorial Science. 19:565-573
Herein, we report selection, synthesis, and enzymatic evaluation of a peptidomimetic library able to increase proteolytic activity of HtrA3 (high temperature requirement A) protease. Iterative deconvolution in solution of synthesized modified pentape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a69ce8edcefefa00178d4062557551b
https://doi.org/10.1021/acscombsci.7b00051
https://doi.org/10.1021/acscombsci.7b00051
Autor:
Łukasz Winiarski, Mateusz Psurski, Marta Świtalska, Łukasz Janczewski, Tadeusz Gajda, Jarosław Ciekot, Joanna Wietrzyk, Tomasz M. Goszczyński, Anna Gajda, Józef Oleksyszyn
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(15)
A series of phosphonates, phosphinates and phosphine oxides isothiocyanate-derived mercapturic acids were synthesized. A temperature dependence dynamic proton decoupled 31P NMR studies indicated that in most cases the compounds were obtained as a mix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1083ea9750dc6adb0ed752ae48c28bc4
https://pubmed.ncbi.nlm.nih.gov/29945793
https://pubmed.ncbi.nlm.nih.gov/29945793
Publikováno v:
Molecules, Vol 29, Iss 5, p 1120 (2024)
Despite many years of research, human neutrophil elastase (HNE) still remains an area of interest for many researchers. This multifunctional representative of neutrophil serine proteases is one of the most destructive enzymes found in the human body
Externí odkaz:
https://doaj.org/article/926babdf69c8444d8d52894599f342ea
Publikováno v:
Journal of Medicinal Chemistry. 55:6541-6553
Herein, we present the synthesis and the measurement of the inhibitory activity of novel peptidyl derivatives of α-aminoalkylphosphonate diaryl esters as human neutrophil elastase inhibitors. Their selectivity against other serine proteases, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c399e5d4df061b46a03d2cbb8383b9d7
https://doi.org/10.1021/jm300599x
https://doi.org/10.1021/jm300599x
Autor:
Łukasz Winiarski, Józef Oleksyszyn, Mateusz Psurski, Marcin Sieńczyk, Paulina Kasperkiewicz, Joanna Wietrzyk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1310-1314
Herein, we describe the synthesis and resulting activity of a complex series of α-aminophosphonate diaryl esters as irreversible human neutrophil elastase inhibitors and their selectivity preference for human neutrophil elastase over several other s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14036e09d8c91c7298ad40e70ec2cd8
https://doi.org/10.1016/j.bmcl.2011.01.083
https://doi.org/10.1016/j.bmcl.2011.01.083
Autor:
Łukasz Winiarski, Agata Rudnicka, Renata Grzywa, Mateusz Psurski, Józef Oleksyszyn, Joanna Wietrzyk, Tadeusz Gajda
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(2)
This Letter deals with new non-natural diisothiocyanates, their mercapturic acid derivatives-conjugated with N-acetylcysteine as well as their antiproliferative activity towards human colon cancer cell lines and their inhibitory potency towards histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187a3d4af805549323d2629b5c2d965f
https://pubmed.ncbi.nlm.nih.gov/26639764
https://pubmed.ncbi.nlm.nih.gov/26639764
Autor:
Joanna Wietrzyk, Łukasz Winiarski, Mateusz Psurski, Marta Pigula, Józef Oleksyszyn, Jarosław Ciekot
Publikováno v:
Tetrahedron Letters. 53:5845-5847
Herein, we describe a convenient method for the syntheses of novel 1-isothiocyano-alkylphosphonate diaryl ester derivatives and their antiproliferative activity. The syntheses are based on dithiocarbamates obtained in situ with the use of carbon disu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ead0c87dba12ba1d081da1f10079697
https://doi.org/10.1016/j.tetlet.2012.08.037
https://doi.org/10.1016/j.tetlet.2012.08.037
Autor:
Pengfei Xu, Mike-Andrew Westhoff, Amina Hadzalic, Klaus-Michael Debatin, Lukasz Winiarski, Jozef Oleksyszyn, Christian Rainer Wirtz, Uwe Knippschild, Timo Burster
Publikováno v:
ACS Omega, Vol 7, Iss 7, Pp 5929-5936 (2022)
Externí odkaz:
https://doaj.org/article/8054992f457a40bb980f1b248e750204
Autor:
Renata Grzywa, Łukasz Winiarski, Magdalena Wysocka, Marcin Sieńczyk, Adam Lesner, Ewa Burchacka, Timo Burster, Maria Łęcka, Maciej A. Walczak, Agnieszka Łupicka-Słowik, Keri Csencsits-Smith, Kamila Bobrek
Publikováno v:
Chembiochem : a European journal of chemical biology. 15(17)
Neutrophils are a type of granulocyte important in the "first line of defense" of the innate immune system. Upon activation, they facilitate the destruction of invading microorganisms by the production of superoxide radicals, as well as the release o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4446ae15e36284e8c30dc9ca9d3c86
https://pubmed.ncbi.nlm.nih.gov/25236966
https://pubmed.ncbi.nlm.nih.gov/25236966