Výsledky vyhledávání - "Łukasz Olech"

Akademický článek

Increased Beta-Hydroxybutyrate Level Is Not Sufficient for the Neuroprotective Effect of Long-Term Ketogenic Diet in an Animal Model of Early Parkinson’s Disease. Exploration of Brain and Liver Energy Metabolism Markers

Autor: Katarzyna Z. Kuter, Łukasz Olech, Urszula Głowacka, Martyna Paleczna

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 14, p 7556 (2021)

The benefits of a ketogenic diet in childhood epilepsy steered up hope for neuroprotective effects of hyperketonemia in Parkinson’s disease (PD). There are multiple theoretical reasons but very little actual experimental proof or clinical trials. W

Externí odkaz: https://doaj.org/article/725ec4ce53d8480b9562fba552a40338

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Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinson's disease

Autor: Katarzyna Z. Kuter, Łukasz Olech, Norbert A. Dencher

Publikováno v: Mitochondrion. 47:227-237

Partial degeneration of dopaminergic neurons in the substantia nigra (SN), induces locomotor disability in animals but with time it is spontaneously compensated for by neurons surviving in the tissue by increasing their functional efficiency. Such co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c850d1adf9e50591b78ad098cbc948f1
https://doi.org/10.1016/j.mito.2018.12.002

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Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA

Autor: Katarzyna Kuter, Urszula Głowacka, Łukasz Olech

Publikováno v: Molecular Neurobiology

Progressive degeneration of dopaminergic neurons in the substantia nigra (SN) is the underlying cause of Parkinson’s disease (PD). The disease in early stages is difficult to diagnose, because behavioral deficits are masked by compensatory processe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06466e46805b91a5e11fb546a7bdb34d
https://doi.org/10.1007/s12035-017-0529-z

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Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration

Autor: Martyna Paleczna, Urszula Głowacka, Łukasz Olech, Katarzyna Kuter

Publikováno v: Journal of neurochemistry. 148(1)

Glial pathology precedes symptoms of Parkinson's disease and multiple other neurodegenerative diseases. Prolonged impairment of astrocytic functions could increase the vulnerability of dopaminergic neurons in the substantia nigra (SN), accelerate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57581d41e3011c6a62a8d4d2a2490672
https://pubmed.ncbi.nlm.nih.gov/30295916

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Antidepressant activity of zinc : further evidence for the involvement of the serotonergic system

Autor: Bernadeta Szewczyk, Agata Siwek, Katarzyna Kotarska, Katarzyna Kuter, Łukasz Olech

Background The present study sought to further evaluate the role of the serotonergic system especially the postsynaptic 5-HT1A receptors (5-HT1AR) in the mechanism of antidepressant action of zinc. Methods Messenger RNA (mRNA), protein level, and 5-H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74863468ecc9653e5284ec0962999cc7
https://ruj.uj.edu.pl/xmlui/handle/item/123098

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