The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

Autor: Elizabeth L. Hardaker, Emilio Sanseviero, Ankur Karmokar, Devon Taylor, Marta Milo, Chrysis Michaloglou, Adina Hughes, Mimi Mai, Matthew King, Anisha Solanki, Lukasz Magiera, Ricardo Miragaia, Gozde Kar, Nathan Standifer, Michael Surace, Shaan Gill, Alison Peter, Sara Talbot, Sehmus Tohumeken, Henderson Fryer, Ali Mostafa, Kathy Mulgrew, Carolyn Lam, Scott Hoffmann, Daniel Sutton, Larissa Carnevalli, Fernando J. Calero-Nieto, Gemma N. Jones, Andrew J. Pierce, Zena Wilson, David Campbell, Lynet Nyoni, Carla P. Martins, Tamara Baker, Gilberto Serrano de Almeida, Zainab Ramlaoui, Abdel Bidar, Benjamin Phillips, Joseph Boland, Sonia Iyer, J. Carl Barrett, Arsene-Bienvenu Loembé, Serge Y. Fuchs, Umamaheswar Duvvuri, Pei-Jen Lou, Melonie A. Nance, Carlos Alberto Gomez Roca, Elaine Cadogan, Susan E. Critichlow, Steven Fawell, Mark Cobbold, Emma Dean, Viia Valge-Archer, Alan Lau, Dmitry I. Gabrilovich, Simon T. Barry

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract The Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical benefit in melanoma and lung cancer patients who progressed on immunotherapy. Here we

Externí odkaz: https://doaj.org/article/189773f2417346dcbdf8b6281d57effa

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

Autor: James C. Kaufman, C. Butter, Charlotte Durant, Clemens Hermann, Susan M. Lea, Paul E. Chappell, Laura Mears, Alejandro Madrigal, Pietro Roversi, William Mwangi, Łukasz Magiera, Venugopal Nair, A.G. Wrobel, El Kahina Meziane, Michael Harrison, Nicola Ternette, Søren Buus, Trudy Ahyee, Lise Lotte Nielsen, Richard Duggleby

Publikováno v: eLife
Chappell, P E, Meziane, E K, Harrison, M, Magiera, Ł, Hermann, C, Mears, L, Wrobel, A G, Durant, C, Nielsen, L L, Buus, S, Ternette, N, Mwangi, W, Butter, C, Nair, V, Ahyee, T, Duggleby, R, Madrigal, A, Roversi, P, Lea, S M & Kaufman, J 2015, ' Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding ', eLIFE, vol. 4, e05345 . https://doi.org/10.7554/eLife.05345
'eLife ', vol: 4, pages: e05345-1-e05345-22 (2015)
eLife, Vol 4 (2015)

Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f2c8367cbb789814503b0acf5cc922
https://www.repository.cam.ac.uk/handle/1810/248451

Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer

Autor: Matthew King, Melissa Chapman, Vasu Sah, Paul Lyne, Alexey Revenko, Charles Sinclair, Ben Johnson, Maneesh Singh, Andrew Watt, Maelle Mairesse, Larissa S Carnevalli, Alison Peter, Molly Taylor, Lisa Hettrick, Stephanie Klein, Anisha Solanki, Danielle Gattis, Adina M Hughes, Lukasz Magiera, Gozde Kar, Lucy Ireland, Deanna A Mele, Josephine Walton, Mark Edbrooke, Simon T Barry, Stephen Fawell, Frederick W Goldberg, A Robert MacLeod

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 4 (2022)

Externí odkaz: https://doaj.org/article/f65818566663472ca06c1db1ef39c009