Výsledky vyhledávání - "İsmail Akçok"

A new drug testing platform based on 3D tri-culture in lab-on-a-chip devices

Autor: Devrim Pesen-Okvur, Ali Cagir, İsmail Akçok, Begum Gokce

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 155

Drug discovery has a 90% rate of failure because preclinical platforms for drug testing do not mimic the in vivo conditions. Doxorubicin (DOX) is a commonly used drug to treat breast cancer patients even though it has side effects. Lab-on-a-chip (LOC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966a0881abc6241aeabf053c63f43e26
https://pubmed.ncbi.nlm.nih.gov/32927074

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Iron-Rich Natural Mineral Gibeon Meteorite Catalyzed N -formylation of Amines using CO2 as the C1 Source

Autor: Arnaud Magrez, Aswin Gopakumar, Florian Le Formal, Loris Lombardo, Ismail Akçok, Paul J. Dyson, Kevin Sivula

Publikováno v: ChemistrySelect. 3:10271-10276

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7d542c1318037974f2c3663e27a9fef
https://doi.org/10.1002/slct.201802646

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Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM

Autor: Murat, Delman, Sanem Tercan, Avcı, İsmail, Akçok, Tuğçe, Kanbur, Esra, Erdal, Ali, Çağır

Publikováno v: European journal of medicinal chemistry. 180

Cytotoxic effects of (R)-4'-methylklavuzon were investigated on hepatocellular carcinoma cells (HuH-7 and HepG2) and HuH-7 EpCAM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51bb559f3d92bed65d72dd2f7d544932
https://pubmed.ncbi.nlm.nih.gov/31306909

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Antiproliferative Activity Of (R)-4 '-Methylklavuzon On Hepatocellular Carcinoma Cells And Epcam(+)/Cd133(+) Cancer Stem Cells Via Sirt1 And Exportin-1 (Crm1) Inhibition

Autor: Sanem Tercan Avci, Ali Cagir, Murat Delman, İsmail Akçok, Esra Erdal, Tuğçe Kanbur

Cytotoxic effects of (R)-4'-methylklavuzon were investigated on hepatocellular carcinoma cells (HuH-7 and HepG2) and HuH-7 EpCAM(+)/CD133(+) cancer stem cells. IC50 of (R)-4'-methylklavuzon was found as 1.25 mu M for HuH-7 parental cells while it was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d344e8ec838c2b5954ab0ba7112d9376
https://aperta.ulakbim.gov.tr/record/74491

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CRM1 inhibitory and antiproliferative activities of novel 4'-alkyl substituted klavuzon derivatives

Autor: Aylin Alkan, İsmail Akçok, Ayhan Şen, Hasan Ozan Otaş, Ali Cagir, Meltem Kutluer, Tuğçe Kanbur, Murat Delman, Murat Kara

Publikováno v: Bioorganicmedicinal chemistry. 25(16)

Klavuzons are 6-(naphthalen-1-yl) substituted 5,6-dihydro-2H-pyran-2-one derivatives showing promising antiproliferative activities in variety of cancer cell lines. In this work, racemic syntheses of nine novel 4′-alkyl substituted klavuzon derivat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cbbcc35eaea2c6acd3e0cdfc1b5f05
https://pubmed.ncbi.nlm.nih.gov/28689976

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Synthesis and Topoisomerase I inhibitory properties of klavuzon derivatives

Autor: Kemal Sami Korkmaz, Pinar Kasaplar, Ayhan Şen, Derya Mete, İsmail Akçok, Ali Cagir

Publikováno v: Bioorganic chemistry. 71

Klavuzon is a naphthalen-1-yl substituted α,β-unsaturated δ-lactone derivative, and is one of the anti-proliferative members of this class of compounds. Asymmetric and racemic syntheses of novel α,β-unsaturated δ-lactone derivatives are importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5b6d00e2418bdf8f1bf0998a568994
https://pubmed.ncbi.nlm.nih.gov/28242062

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Evaluation Of Multifunctional Hybrid Analogs For Stilbenes, Chalcones And Flavanones

Autor: Ali Cagir, İsmail Akçok, Burcu Odaci, Ayşe Tansu Koparal, Özgür Okur, Mehmet Varol

WOS: 000424633600005
PubMed ID: 28554313
Aims: In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone der

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03621e380290fa92b0f1c9ec1cc2574
https://aperta.ulakbim.gov.tr/record/50229

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ChemInform Abstract: A Rhodium Nanoparticle-Lewis Acidic Ionic Liquid Catalyst for the Chemoselective Reduction of Heteroarenes

Autor: Aswin Gopakumar, Bastien L. Roulier, Sergey A. Katsyuba, Alena Karakulina, Thomas LaGrange, Shoubhik Das, İsmail Akçok, Paul J. Dyson

Publikováno v: ChemInform. 47

We describe a catalytic system composed of rhodium nanoparticles immobilized in a Lewis acidic ionic liquid. The combined system catalyzes the hydrogenation of quinolines, pyridines, benzofurans, and furan to access the corresponding heterocycles, im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75e39a6bc2e773f51ab6f8af01dd64a5
https://doi.org/10.1002/chin.201619036

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ChemInform Abstract: One-Pot Vinylogous Aldol Addition of β,γ-Unsaturated Esters under Mild Conditions

Autor: İsmail Akçok, Ali Cagir

Publikováno v: ChemInform. 46

We described a one-pot vinylogous aldol addition of methyl 3-butenoate to aromatic aldehydes in the presence of silver salts and the TMSCl–TBAF mixture. The reaction can be done simply by sequentially mixing reagents in situ, and it does not requir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe2d1595ebf52c4eab1687ba6f9b027e
https://doi.org/10.1002/chin.201545056

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