Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Üzen Savas"'
Publikováno v:
Molecular Pharmacology. 93:14-24
The contributions of cytochrome P450 3A5 to the metabolic clearance of marketed drugs is unclear, but its probable role is to augment the metabolism of several drugs that are largely cleared by P450 3A4. Selective metabolism by 3A4 is often a concern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae3d5eeeb2378fe1629e6b05b4d9f44
https://doi.org/10.1124/mol.117.109744
https://doi.org/10.1124/mol.117.109744
Autor:
Chul-Ho Yun, Matthew E. Albertolle, Donghak Kim, Üzen Savas, Ambra Pozzi, Leslie D. Nagy, Eric F. Johnson, F. Peter Guengerich
Publikováno v:
Journal of Biological Chemistry. 292:11230-11242
Cytochrome P450 (P450, CYP) 4A11 is a human fatty acid ω-hydroxylase that catalyzes the oxidation of arachidonic acid to the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE), which plays important roles in regulating blood pressure regulation. V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8e70c9930650e82c8d5f1871a48256
https://doi.org/10.1074/jbc.m117.792200
https://doi.org/10.1074/jbc.m117.792200
Autor:
F. Peter Guengerich, John R. Falck, Mei Hui Hsu, Jorge H. Capdevila, Üzen Savas, Shouzou Wei, Eric F. Johnson
Publikováno v:
Journal of Biological Chemistry. 291:16904-16919
Male and female homozygous 129/Sv mice carrying four copies of the human cytochrome P450 4A11 gene (CYP4A11) under control of its native promoter (B-129/Sv-4A11(+/+)) develop hypertension (142 ± 8 versus 113 ± 7 mm Hg systolic blood pressure (BP)),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57dc5e2fcffc190446321cc3dd2c031d
https://doi.org/10.1074/jbc.m116.732297
https://doi.org/10.1074/jbc.m116.732297
Publikováno v:
Journal of Biological Chemistry. 287:10834-10843
Human cytochrome P450 2D6 contributes to the metabolism of >15% of drugs used in clinical practice. This study determined the structure of P450 2D6 complexed with a substrate and potent inhibitor, prinomastat, to 2.85 A resolution by x-ray crystallog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869bdc16213870f31f890a9863dbce25
https://doi.org/10.1074/jbc.m111.307918
https://doi.org/10.1074/jbc.m111.307918
Publikováno v:
Archives of Biochemistry and Biophysics. 409:212-220
HepG2 cells that stably overexpress PPARalpha were used to examine the regulation of the two known human CYP4A genes by Wy14643. Specific PCR amplification across intron 5 and restriction endonuclease analysis indicated that HepG2 cells possess genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce8190aa62909c417c53c3647b5636e
https://doi.org/10.1016/s0003-9861(02)00499-x
https://doi.org/10.1016/s0003-9861(02)00499-x
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 337(1)
Activators of AMP-activated protein kinase (AMPK) increase the expression of the human microsomal fatty acid ω-hydroxylase CYP4F2. A 24-h treatment of either primary human hepatocytes or the human hepatoma cell line HepG2 with 5-aminoimidazole-4-car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429521476a162e802a0d92048be71bf6
https://pubmed.ncbi.nlm.nih.gov/21205922
https://pubmed.ncbi.nlm.nih.gov/21205922
Autor:
Jerome M. Lasker, Mei-Hui Hsu, Pryce Gaynor, Daniel E. W. Machemer, Eric F. Johnson, Üzen Savas, Robert H. Tukey
Publikováno v:
The Journal of biological chemistry. 284(24)
CYP4A11 transgenic mice (CYP4A11 Tg) were generated to examine in vivo regulation of the human CYP4A11 gene. Expression of CYP4A11 in mice yields liver and kidney P450 4A11 levels similar to those found in the corresponding human tissues and leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47a9e1e3712042115364fca932e04fb
https://pubmed.ncbi.nlm.nih.gov/19366684
https://pubmed.ncbi.nlm.nih.gov/19366684
Publikováno v:
Drug metabolism reviews. 39(2-3)
The microsomal cytochrome P450 (CYP) family 4 monooxygenases are the major fatty acid omega-hydroxylases. These enzymes remove excess free fatty acids to prevent lipotoxicity, catabolize leukotrienes and prostanoids, and also produce bioactive metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c161df2ae094a0c26e81d704c05688
https://pubmed.ncbi.nlm.nih.gov/17786636
https://pubmed.ncbi.nlm.nih.gov/17786636
Publikováno v:
Archives of biochemistry and biophysics. 436(2)
Cytochrome P450 genes (CYPs) encoding two new subfamilies designated CYP4X1 and CYP4Z1 were identified in the human genome and the Expressed Sequence Tags database. Partial cDNAs encoding both P450s were isolated from human kidney and used to determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3810b9a294ead5ec7a42e412e825cef2
https://pubmed.ncbi.nlm.nih.gov/15797250
https://pubmed.ncbi.nlm.nih.gov/15797250
Publikováno v:
Toxicology.
The induction of P450 4A enzymes by peroxisome proliferators (PPs) and fatty acids is mediated by the peroxisome proliferator activated receptor alpha (PPAR alpha) that binds to response elements in target genes as a heterodimer with the retinoid X r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2304289e1e0887311e2dcfe72186522
https://pubmed.ncbi.nlm.nih.gov/12505311
https://pubmed.ncbi.nlm.nih.gov/12505311