Zobrazeno 1 - 10
of 611
pro vyhledávání: '"Ús terapèutic"'
Autor:
Harry L A Janssen, Jinlin Hou, Tarik Asselah, Henry L Y Chan, Fabien Zoulim, Yasuhito Tanaka, Ewa Janczewska, Ronald G Nahass, Stefan Bourgeois, Maria Buti, Pietro Lampertico, Oliver Lenz, Thierry Verbinnen, Joris Vandenbossche, Willem Talloen, Ronald Kalmeijer, Maria Beumont, Michael Biermer, Umesh Shukla
Publikováno v:
Gut. BMJ Publishing Group
Scientia
Scientia
ObjectiveWe present the final analysis results of the phase 2 JADE study (ClinicalTrials.gov Identifier:NCT03361956).Design232 patients with chronic hepatitis B (CHB) not currently treated at study start (NCT) at study start or virologically suppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f702b8cc4a17edfe62562c85466ffa3f
https://doi.org/10.1136/gutjnl-2022-328041
https://doi.org/10.1136/gutjnl-2022-328041
Autor:
Evan Y. Yu, Josep M. Piulats, Gwenaelle Gravis, Peter C.C. Fong, Tilman Todenhöfer, Brigitte Laguerre, Jose A. Arranz, Stephane Oudard, Christophe Massard, Julia Heinzelbecker, Luke T. Nordquist, Joan Carles, Michael P. Kolinsky, Marinela Augustin, Howard Gurney, Ali Tafreshi, Xin Tong Li, Ping Qiu, Christian H. Poehlein, Charles Schloss, Johann S. de Bono
Publikováno v:
Scientia
Metastatic castration-resistant prostate cancer; Olaparib; Pembrolizumab Cáncer de próstata metastásico resistente a la castración; Olaparib; Pembrolizumab Càncer de pròstata metastàtic resistent a la castració; Olaparib; Pembrolizumab Backgr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca3f75fdc923eda1b2b738df1dc19c8
https://doi.org/10.1016/j.eururo.2022.08.005
https://doi.org/10.1016/j.eururo.2022.08.005
Autor:
Marina C. Garassino, Shirish Gadgeel, Giovanna Speranza, Enriqueta Felip, Emilio Esteban, Manuel Dómine, Maximilian J. Hochmair, Steven F. Powell, Helge G. Bischoff, Nir Peled, Francesco Grossi, Ross R. Jennens, Martin Reck, Rina Hui, Edward B. Garon, Takayasu Kurata, Jhanelle E. Gray, Paul Schwarzenberger, Erin Jensen, M. Catherine Pietanza, Delvys Rodríguez-Abreu
Publikováno v:
Scientia
Pembrolizumab; Non-small-cell lung cancer Pembrolizumab; Cáncer de pulmón de células no pequeñas Pembrolizumab; Càncer de pulmó de cèl·lules no petites Clinical trials frequently include multiple end points that mature at different times. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374e74c86ca13e92597e504ff2706d68
https://doi.org/10.1200/jco.22.01989
https://doi.org/10.1200/jco.22.01989
Autor:
Ruben A. Mesa, Stacie Hudgens, Lysbeth Floden, Claire N. Harrison, Jeanne Palmer, Vikas Gupta, Donal P. McLornan, Mary F. McMullin, Jean‐Jaques Kiladjian, Lynda Foltz, Uwe Platzbecker, M. Laura Fox, Adam J. Mead, David M. Ross, Stephen T. Oh, Andrew Perkins, Michael F. Leahy, Samineh Deheshi, Rafe Donahue, Barbara J. Klencke, Srdan Verstovsek
Publikováno v:
Mesa, R A, Hudgens, S, Floden, L, Harrison, C N, Palmer, J, Gupta, V, McLornan, D P, McMullin, M F, Kiladjian, J-J, Foltz, L, Platzbecker, U, Fox, M L, Mead, A J, Ross, D M, Oh, S T, Perkins, A, Leahy, M F, Deheshi, S, Donahue, R, Klencke, B J & Verstovsek, S 2023, ' Symptomatic benefit of momelotinib in patients with myelofibrosis: results from the SIMPLIFY phase III studies ', Cancer Medicine . https://doi.org/10.1002/cam4.5799
Scientia
Scientia
Momelotinib; Myelofibrosis; Patient-reported outcomes Momelotinib; Mielofibrosi; Resultats informats pel pacient Momelotinib; Mielofibrosis; Resultados informados por el paciente Background Myelofibrosis (MF)-associated constitutional symptoms can se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfbb9cc40d930868fce1d2a253b5f47
https://doi.org/10.1002/cam4.5799
https://doi.org/10.1002/cam4.5799
Autor:
Alessandro D Santin, Ignace Vergote, Antonio González-Martín, Kathleen Moore, Ana Oaknin, Ignacio Romero, Sami Diab, Larry J Copeland, Bradley J Monk, Robert L Coleman, Thomas J Herzog, Jonathan Siegel, Linda Kasten, Andreas Schlicker, Anke Schulz, Karl Köchert, Annette O Walter, Barrett H Childs, Cem Elbi, Iurie Bulat
Publikováno v:
Scientia
ObjectivesAnetumab ravtansine is an antibody-drug conjugate consisting of a fully human anti-mesothelin monoclonal antibody conjugated to cytotoxic maytansinoid tubulin inhibitor DM4. Mesothelin is highly expressed in ovarian cancer. This phase Ib st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a0c0b8ed9cef8add723b9465b06491
https://doi.org/10.1136/ijgc-2022-003927
https://doi.org/10.1136/ijgc-2022-003927
Autor:
Neeltje Steeghs, Aaron R. Hansen, Glenn J. Hanna, Elena Garralda, Haeseong Park, James Strauss, Michael Adam, Gossett Campbell, Jennifer Carver, Rachael Easton, Katherine Mays, Peter Skrdla, Herbert Struemper, Michael L. Washburn, Christopher Matheny, Sarina A. Piha‐Paul
Publikováno v:
Scientia
Biological activity; Solid tumors Actividad biológica; Tumores sólidos Activitat biològica; Tumors sòlids A phase I trial (NCT03447314; 204686) evaluated the safety and efficacy of GSK1795091, a Toll-like receptor 4 (TLR4) agonist, in combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52a2c776e6853dfc712d9d3e7b04e11
https://doi.org/10.1111/cts.13387
https://doi.org/10.1111/cts.13387
Autor:
Marco Falcone, Michael Bauer, Ricard Ferrer, Gaëtan Gavazzi, Juan Gonzalez del Castillo, Alberto Pilotto, Philipp Schuetz
Publikováno v:
Scientia
Purpose Optimal treatment of infections in the elderly patients population is challenging because clinical symptoms and signs may be less specific potentially resulting in both, over- and undertreatment. Elderly patients also have a less pronounced i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042d2c9a4fd13ec04d686ffead7f43f5
https://doi.org/10.1007/s40520-023-02388-w
https://doi.org/10.1007/s40520-023-02388-w
Autor:
Caterina Carbonell, Joan Frigola, Nuria Pardo, Ana Callejo, Patricia Iranzo, Augusto Valdivia, Ilaria Priano, Susana Cedrés, Alex Martinez‐Marti, Alejandro Navarro, Laura Lenza, Mireia Soleda, Javier Gonzalo‐Ruiz, Ana Vivancos, Miriam Sansó, Enric Carcereny, Teresa Morán, Ramon Amat, Enriqueta Felip
Publikováno v:
Scientia
Immune checkpoint inhibitors; Liquid biopsy Inhibidores del punto de control inmunitario; Biopsia líquida Inhibidors del punt de control immunitari; Biòpsia líquida Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis are the main the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4156dbba9cbf2c8c3049073dd52fe1ee
https://doi.org/10.1002/1878-0261.13409
https://doi.org/10.1002/1878-0261.13409
Autor:
Josep Tabernero, Eric Van Cutsem, Elena Garralda, David Tai, Filippo De Braud, Ravit Geva, Mark T J van Bussel, Katia Fiorella Dotti, Elena Elez, María J de Miguel, Kevin Litwiler, Danielle Murphy, Michelle Edwards, Van Karlyle Morris
Publikováno v:
Scientia
Background WNT974 is a small molecule inhibitor of Wnt signaling that specifically inhibits porcupine O-acyltransferase. This phase Ib dose-escalation study evaluated the maximum tolerated dose of WNT974 in combination with encorafenib and cetuxima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5f044abd821df8649f422f22924992
https://doi.org/10.1093/oncolo/oyad007
https://doi.org/10.1093/oncolo/oyad007
Autor:
Beatriz Mateos-Muñoz, María Buti, Inmaculada Fernández Vázquez, Marta Hernández Conde, Vanesa Bernal-Monterde, Fernando Díaz-Fontenla, Rosa María Morillas, Luisa García-Buey, Ester Badía, Mireia Miquel, Alberto Amador-Navarrete, Sergio Rodríguez-Tajes, Lucía Ramos-Merino, Antonio Madejón, Montserrat García-Retortillo, Juan Ignacio Arenas, Joaquín Cabezas, Jesús Manuel González Santiago, Conrado Fernández-Rodríguez, Patricia Cordero, Moisés Diago, Antonio Mancebo, Alberto Pardo, Manuel Rodríguez, Elena Hoyas, Jose Javier Moreno, Juan Turnes, Miguel Ángel Simón, Cristina Marcos-Fosch, Jose Luis Calleja, Rafael Bañares, Sabela Lens, Javier Garcia-Samaniego, Javier Crespo, Manuel Romero-Gomez, Francisco Gea, Enrique Rodríguez de Santiago, Santiago Moreno, Agustin Albillos
Publikováno v:
Scientia
COVID-19; Hepatitis B; Tenofovir COVID-19; Hepatitis B; Tenofovir COVID-19; Hepatitis B; Tenofovir Background and Aims HIV-positive patients on tenofovir hydroxyl fumarate (TDF)/emtricitabine have a lower risk of COVID-19 and hospitalization than tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932ba24b491187cb9df755c7b3aa7bd2
https://doi.org/10.1007/s10620-022-07817-w
https://doi.org/10.1007/s10620-022-07817-w