Výsledky vyhledávání - "Øystein Sandanger"

Akademický článek

Therapeutic drug monitoring of infliximab compared to standard clinical treatment with infliximab: study protocol for a randomised, controlled, open, parallel-group, phase IV study (the NOR-DRUM study)

Autor: Silje W Syversen, Guro L Goll, Kristin K Jørgensen, Inge C Olsen, Øystein Sandanger, Johanna E Gehin, David J Warren, Joseph Sexton, Cato Mørk, Jørgen Jahnsen, Tore K Kvien, Nils Bolstad, Espen A Haavardsholm

Publikováno v: Trials, Vol 21, Iss 1, Pp 1-14 (2020)

Abstract Background Infliximab (INX) and other tumour necrosis factor inhibitors (TNFi) have revolutionised the treatment of several immune mediated inflammatory diseases. Still, many patients do not respond sufficiently to therapy or lose efficacy o

Externí odkaz: https://doaj.org/article/11bb110f7ddd42829b9b89f716ce949f

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Akademický článek

Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis

Publikováno v: EBioMedicine, Vol 60, Iss , Pp 102985- (2020)

Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome. We investigated th

Externí odkaz: https://doaj.org/article/39981b8ba8fe4c45a1e11befa1b7bd07

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Akademický článek

Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1β Expression in Primary Mouse Cardiac Fibroblasts

Autor: May-Kristin Torp, Kuan Yang, Trine Ranheim, Knut Husø Lauritzen, Katrine Alfsnes, Leif E. Vinge, Pål Aukrust, Kåre-Olav Stensløkken, Arne Yndestad, Øystein Sandanger

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Background: IL-1β is a highly potent pro-inflammatory cytokine and its secretion is tightly regulated. Inactive pro-IL-1β is transcribed in response to innate immune receptors activating NFκB. If tissue damage occurs, danger signals released from

Externí odkaz: https://doaj.org/article/6eee4de1f29449818e0703c36db3558b

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Akademický článek

Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice

Autor: Yangchen Dhondup, Ivar Sjaastad, Øystein Sandanger, Jan Magnus Aronsen, Muhammad Shakil Ahmed, Håvard Attramadal, Alexandra Vanessa Finsen, Lili Zhang, Trine Ranheim, Katrine Alfsnes, Pål Aukrust, Geir Christensen, Arne Yndestad, Leif Erik Vinge

Publikováno v: Mediators of Inflammation, Vol 2017 (2017)

Aim. Inflammation is important in heart failure (HF). The role of the immune receptor toll-like receptor 9 (TLR9) in HF is not understood and not investigated in diastolic HF. We investigated the role of TLR9 in a murine diastolic HF model caused by

Externí odkaz: https://doaj.org/article/574432b69998439ab5a5f81e21132c63

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Akademický článek

Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation.

Autor: Ida Gregersen, Øystein Sandanger, Erik T Askevold, Ellen Lund Sagen, Kuan Yang, Sverre Holm, Turid M Pedersen, Mona Skjelland, Kirsten Krohg-Sørensen, Trond Vidar Hansen, Tuva Børresdatter Dahl, Kari Otterdal, Terje Espevik, Pål Aukrust, Arne Yndestad, Bente Halvorsen

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0188387 (2017)

Interleukin-27 (IL-27) is involved in different inflammatory diseases; however, its role in atherosclerosis is unclear. In this study we investigated the expression of IL-27 and its receptor in patients with carotid atherosclerosis and if IL-27 could

Externí odkaz: https://doaj.org/article/8ff1cd806d784a3d8345ac2aa7924a0a

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Akademický článek

Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice.

Autor: Yangchen Dhondup, Ivar Sjaastad, Helge Scott, Øystein Sandanger, Lili Zhang, Solveig Bjærum Haugstad, Jan Magnus Aronsen, Trine Ranheim, Sigve Dhondup Holmen, Katrine Alfsnes, Muhammad Shakil Ahmed, Håvard Attramadal, Lars Gullestad, Pål Aukrust, Geir Christensen, Arne Yndestad, Leif Erik Vinge

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0139715 (2015)

AIM:Cardiac inflammation is important in the pathogenesis of heart failure. However, the consequence of systemic inflammation on concomitant established heart failure, and in particular diastolic heart failure, is less explored. Here we investigated

Externí odkaz: https://doaj.org/article/430cff5cb94d46239bb2049bbba4ceda

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Akademický článek

Toll-like receptor 9 mediated responses in cardiac fibroblasts.

Autor: Ingrid Kristine Ohm, Katrine Alfsnes, Maria Belland Olsen, Trine Ranheim, Øystein Sandanger, Tuva Børresdatter Dahl, Pål Aukrust, Alexandra Vanessa Finsen, Arne Yndestad, Leif Erik Vinge

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104398 (2014)

Altered cardiac Toll-like receptor 9 (TLR9) signaling is important in several experimental cardiovascular disorders. These studies have predominantly focused on cardiac myocytes or the heart as a whole. Cardiac fibroblasts have recently been attribut

Externí odkaz: https://doaj.org/article/33f1cfe2816f446cb13229e88deea271

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Akademický článek

The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure.

Autor: Arne Yndestad, Alexandra Vanessa Finsen, Thor Ueland, Cathrine Husberg, Christen P Dahl, Erik Øie, Leif Erik Vinge, Ivar Sjaastad, Øystein Sandanger, Trine Ranheim, Kenneth Dickstein, John Kjekshus, Jan Kristian Damås, Arnt E Fiane, Denise Hilfiker-Kleiner, Martin Lipp, Lars Gullestad, Geir Christensen, Pål Aukrust

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33038 (2012)

BACKGROUND: CCL19 and CCL21, acting through CCR7, are termed homeostatic chemokines. Based on their role in concerting immunological responses and their proposed involvement in tissue remodeling, we hypothesized that these chemokines could play a pat

Externí odkaz: https://doaj.org/article/fa097ed2b7474920a2599b5b31aabb1c

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