Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Ørjan Samuelsen"'
Autor:
Tamim Khawaja, Tommi Mäklin, Teemu Kallonen, Rebecca A. Gladstone, Anna K. Pöntinen, Sointu Mero, Harry A. Thorpe, Ørjan Samuelsen, Julian Parkhill, Mateen Izhar, M. Waheed Akhtar, Jukka Corander, Anu Kantele
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Multi-drug resistant (MDR) E. coli constitute a major public health burden globally, reaching the highest prevalence in the global south yet frequently flowing with travellers to other regions. However, our comprehension of the entire geneti
Externí odkaz:
https://doaj.org/article/d635e9e4516f48f2a27f06a072b4c6c3
Autor:
Sergio Arredondo-Alonso, George Blundell-Hunter, Zuyi Fu, Rebecca A. Gladstone, Alfred Fillol-Salom, Jessica Loraine, Elaine Cloutman-Green, Pål J. Johnsen, Ørjan Samuelsen, Anna K. Pöntinen, François Cléon, Susana Chavez-Bueno, Miguel A. De la Cruz, Miguel A. Ares, Manivanh Vongsouvath, Agnieszka Chmielarczyk, Carolyne Horner, Nigel Klein, Alan McNally, Joice N. Reis, José R. Penadés, Nicholas R. Thomson, Jukka Corander, Peter W. Taylor, Alex J. McCarthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in
Externí odkaz:
https://doaj.org/article/e6fa52774e4f424f982560f7102a17a7
Autor:
Tommi Mäklin, Harry A. Thorpe, Anna K. Pöntinen, Rebecca A. Gladstone, Yan Shao, Maiju Pesonen, Alan McNally, Pål J. Johnsen, Ørjan Samuelsen, Trevor D. Lawley, Antti Honkela, Jukka Corander
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Opportunistic bacterial pathogen species frequently colonise the human gut as a normal part of the ecosystem but strain-level colonisation and competition dynamics in healthy hosts is yet to be established. Authors seek to understand the relationship
Externí odkaz:
https://doaj.org/article/8e93f7b998b34aaf9e526e352acf40b3
Autor:
Niclas Raffelsberger, Dorota Julia Buczek, Kristian Svendsen, Lars Småbrekke, Anna Kaarina Pöntinen, Iren H. Löhr, Lotte Leonore Eivindsdatter Andreassen, Gunnar Skov Simonsen, Arnfinn Sundsfjord, Kirsten Gravningen, Ørjan Samuelsen
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT The global prevalence of infections caused by extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) is increasing, and for Escherichia coli, observations indicate that this is partly driven by community-onset cases. The ESBL-E p
Externí odkaz:
https://doaj.org/article/92fbb9207ddf431b88472033122999bf
Autor:
Kenneth Lindstedt, Dorota Buczek, Torunn Pedersen, Erik Hjerde, Niclas Raffelsberger, Yutaka Suzuki, Sylvain Brisse, Kathryn Holt, Ørjan Samuelsen, Arnfinn Sundsfjord
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Klebsiella pneumoniae is an important opportunistic healthcare-associated pathogen and major contributor to the global spread of antimicrobial resistance. Gastrointestinal colonization with K. pneumoniae is a major predisposing risk factor for infect
Externí odkaz:
https://doaj.org/article/51c0447b2b644deb953b6957606d79a2
Autor:
Vidar Sørum, Emma L. Øynes, Anna S. Møller, Klaus Harms, Ørjan Samuelsen, Nicole L. Podnecky, Pål J. Johnsen
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Collateral sensitivity and resistance occur when resistance development toward one antimicrobial either potentiates or deteriorates the effect of others. Previous reports on collateral effects on susceptibility focus on newly acquired resist
Externí odkaz:
https://doaj.org/article/1ee931cbd5cf489abdfb3468fc1c94ac
Autor:
Hanna‐Kirsti S. Leiros, Ane Molden Thomassen, Ørjan Samuelsen, Carl‐Fredrik Flach, Stathis D. Kotsakis, D.G. Joakim Larsson
Publikováno v:
FEBS Open Bio, Vol 10, Iss 9, Pp 1821-1832 (2020)
Carbapenemases are the main cause of carbapenem resistance in Gram‐negative bacteria. How β‐lactamases with weak carbapenemase activity, such as the OXA‐10‐type class D β‐lactamases, contribute to anti‐bacterial drug resistance is uncle
Externí odkaz:
https://doaj.org/article/62cb712f7c1a4858bec1f689a4a0fc63
Autor:
Supathep Tansirichaiya, Richard N. Goodman, Xinyu Guo, Issra Bulgasim, Ørjan Samuelsen, Mohammed Al-Haroni, Adam P. Roberts
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT Mobile genetic elements (MGEs) are often associated with antimicrobial resistance genes (ARGs). They are responsible for intracellular transposition between different replicons and intercellular conjugation and are therefore important agents
Externí odkaz:
https://doaj.org/article/7dda22f69fa741fcafdb9bf740794772
Autor:
Aleksandra Jakovljev, Jan Egil Afset, Kjersti Haugum, Harald Otto Steinum, Torunn Gresdal Rønning, Ørjan Samuelsen, Christina Gabrielsen Ås
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270256 (2022)
IntroductionThymine auxotrophic in vitro mutants of Escherichia coli were first reported in the mid-20th century. Later, thymine-dependent clinical strains of E. coli as well as other Enterobacterales, Enterococcus faecalis and Staphylococcus aureus
Externí odkaz:
https://doaj.org/article/69d3f00457cf4725885aa3e588b31350
Autor:
Jónína S. Guðmundsdóttir, Elizabeth G.A. Fredheim, Catharina I.M. Koumans, Joachim Hegstad, Po-Cheng Tang, Dan I. Andersson, Ørjan Samuelsen, Pål J. Johnsen
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103742- (2021)
Background: Understanding drivers of antibiotic resistance evolution is fundamental for designing optimal treatment strategies and interventions to reduce the spread of antibiotic resistance. Various cytotoxic drugs used in cancer chemotherapy have a
Externí odkaz:
https://doaj.org/article/ec68090bd0bc46cbb788a8646dfb8f2d