DNA methylation markers for sensitive detection of circulating tumor DNA in patients with gastroesophageal cancers

Autor: Øgaard, N., Iden, C.R., Jensen, S.Ø., Mustafa, S.M., Aagaard, E., Bramsen, J.B., Ahlborn, L.B., Hasselby, J.P., Rohrberg, K.S., Achiam, M.P., Andersen, C.L., Mau-Sørensen, M.

Publikováno v: In ESMO Gastrointestinal Oncology December 2024 6

Circulating tumour DNA and risk of recurrence in patients with asymptomatic versus symptomatic colorectal cancer.

Autor: Øgaard N; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark., Jensen SØ; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark., Ørntoft MW; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Surgery, Gødstrup Hospital, Herning, Denmark., Demuth C; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark., Rasmussen MH; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark., Henriksen TV; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark., Nors J; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark., Frydendahl A; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark., Lyskjær I; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark., Nesic M; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark., Therkildsen C; Gastro Unit, Surgical Section, Copenhagen University Hospital, Amager-Hvidovre, Denmark., Kleif J; Gastro Unit, Surgical Section, Copenhagen University Hospital, Amager-Hvidovre, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Gögenur M; Center for Surgical Science, Department of Surgery, Zealand University Hospital, Køge, Denmark., Jørgensen LN; Digestive Disease Centre, Bispebjerg Hospital, Copenhagen, Denmark., Vilandt J; Department of Surgery, Nordsjællands Hospital, Hillerød, Denmark., Seidelin JB; Department of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark., Gotschalck KA; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.; Department of Surgery, Horsens Hospital, Horsens, Denmark., Jaensch C; Department of Surgery, Gødstrup Hospital, Herning, Denmark., Andersen B; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.; Department of Public Health Programs and University Research Clinic for Cancer Screening, Randers Regional Hospital, Randers, Denmark., Løve US; Department of Surgery, Viborg Hospital, Viborg, Denmark., Thorlacius-Ussing O; Clinical Cancer Research Center, Aalborg University, Aalborg, Denmark., Andersen PV; Department of Surgery, Odense University Hospital, Odense, Denmark., Kolbro T; Department of Surgery, Odense University Hospital, Svendborg, Denmark., Monti A; Department of Surgery, North Denmark Regional Hospital Hjørring, Hjørring, Denmark., Kildsig J; Department of Surgery, Copenhagen University Hospital, Herlev, Denmark., Bondeven P; Department of Surgery, Regional Hospital Randers, Randers, Denmark., Schlesinger NH; Digestive Disease Centre, Bispebjerg Hospital, Copenhagen, Denmark., Iversen LH; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.; Department of Surgery, Aarhus University Hospital, Aarhus, Denmark., Rasmussen M; Digestive Disease Centre, Bispebjerg Hospital, Copenhagen, Denmark., Gögenur I; Center for Surgical Science, Department of Surgery, Zealand University Hospital, Køge, Denmark., Bramsen JB; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark., Andersen CL; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark. cla@clin.au.dk.; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark. cla@clin.au.dk.

Publikováno v: British journal of cancer [Br J Cancer] 2024 Nov; Vol. 131 (10), pp. 1707-1715. Date of Electronic Publication: 2024 Oct 10.

Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment.

Autor: Widman AJ; New York Genome Center, New York, NY, USA. widmana@mskcc.org.; Memorial Sloan Kettering Cancer Center, New York, NY, USA. widmana@mskcc.org., Shah M; New York Genome Center, New York, NY, USA., Frydendahl A; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Halmos D; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Khamnei CC; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Øgaard N; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Rajagopalan S; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Arora A; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Deshpande A; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Hooper WF; New York Genome Center, New York, NY, USA., Quentin J; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Bass J; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Zhang M; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Langanay T; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Andersen L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Steinsnyder Z; New York Genome Center, New York, NY, USA., Liao W; New York Genome Center, New York, NY, USA., Rasmussen MH; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Henriksen TV; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Jensen SØ; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nors J; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Therkildsen C; Gastro Unit, Copenhagen University Hospital, Amager - Hvidovre Hospital, Hvidovre, Denmark., Sotelo J; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Brand R; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Schiffman JS; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Shah RH; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cheng AP; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Maher C; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Spain L; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London, UK., Krause K; Mass General Cancer Center, Massachusetts General Hospital, Boston, MA, USA., Frederick DT; Mass General Cancer Center, Massachusetts General Hospital, Boston, MA, USA., den Brok W; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Lohrisch C; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Shenkier T; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Simmons C; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Villa D; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Mungall AJ; Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Moore R; Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Zaikova E; Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Cerda V; Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Kong E; Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Lai D; Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Malbari MS; Weill Cornell Medicine, New York, NY, USA., Marton M; New York Genome Center, New York, NY, USA., Manaa D; New York Genome Center, New York, NY, USA., Winterkorn L; New York Genome Center, New York, NY, USA., Gelmon K; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Callahan MK; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boland G; Mass General Cancer Center, Massachusetts General Hospital, Boston, MA, USA., Potenski C; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Wolchok JD; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Saxena A; Weill Cornell Medicine, New York, NY, USA., Turajlic S; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London, UK., Imielinski M; New York Genome Center, New York, NY, USA.; Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA., Berger MF; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Aparicio S; Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Altorki NK; Weill Cornell Medicine, New York, NY, USA., Postow MA; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Robine N; New York Genome Center, New York, NY, USA., Andersen CL; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Landau DA; New York Genome Center, New York, NY, USA. dlandau@nygenome.org.; Weill Cornell Medicine, New York, NY, USA. dlandau@nygenome.org.

Publikováno v: Nature medicine [Nat Med] 2024 Jun; Vol. 30 (6), pp. 1655-1666. Date of Electronic Publication: 2024 Jun 14.

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[Circulating tumour DNA in the treatment of cancer].

Autor: Iden CR, Johansen AFB, Øgaard N, Kongsfelt IB, Egebjerg K, Andersen CL, Mau-Sørensen M; mms@rh.regionh.dk.

Publikováno v: Ugeskrift for laeger [Ugeskr Laeger] 2021 Aug 09; Vol. 183 (32).