Persistent directional cell migration requires ion transport proteins as direction sensors and membrane potential differences in order to maintain directedness

Autor: Sharma Priyanka, Perike Srikanth, Özkucur Nurdan, Funk Richard HW

Publikováno v: BMC Cell Biology, Vol 12, Iss 1, p 4 (2011)

Abstract Background Ion transport proteins generate small electric fields that can induce directional cell motility; however, little is known about their mechanisms that lead to directedness. We investigated Na, K-ATPase (NaKA) and Na+/H+ exchanger i

Externí odkaz: https://doaj.org/article/d418995dcbf94c91b9539dead01762c4

Phospho-NHE3 forms membrane patches and interacts with beta-actin to sense and maintain constant direction during cell migration

Autor: Perike, Srikanth, Özkucur, Nurdan, Sharma, Priyanka, Staroske, Wolfgang, Bläsche, Robert, Barth, Kathrin, Funk, Richard HW

Publikováno v: In Experimental Cell Research 15 May 2014 324(1):13-29

Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures.

Autor: Özkucur, Nurdan^1,2, Quinn, Kyle P.¹, Pang, Jin C.³, Du, Chuang^1,4, Georgakoudi, Irene¹, Miller, Eric³, Levin, Michael², Kaplan, David L.¹

Publikováno v: Brain & Behavior. Jan2015, Vol. 5 Issue 1, p24-N.PAG. 15p.

NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells

Autor: Özkucur, Nurdan, Song, Bing, Bola, Sharanya, Zhang, Lei, Reid, Brian, Fu, Guo, Funk, Richard HW, Zhao, Min

Publikováno v: Özkucur, N; Song, B; Bola, S; Zhang, L; Reid, B; Fu, G; et al.(2014). NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells. Cellular and Molecular Life Sciences, 71(23), 4653-4663. doi: 10.1007/s00018-014-1632-1. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6m9942ck
Cellular and molecular life sciences : CMLS, vol 71, iss 23

© 2014 Springer Basel. Endogenous electric fields (EF) may provide an overriding cue for directional cell migration during wound closure. Perceiving a constant direction requires active sodium-hydrogen exchanger (pNHE3) at the leading edge of HEK 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6a235c1cc41c35001edcb55865297c40
http://www.escholarship.org/uc/item/6m9942ck

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