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Identification of Boronic Acid Derivatives as an Active Form of N‑Alkylaminoferrocene-Based Anticancer Prodrugs and Their Radiolabeling with ¹⁸F.

Autor: Daum, Steffen, Toms, Johannes, Reshetnikov, Viktor, Özkan, Hülya Gizem, Hampel, Frank, Maschauer, Simone, Hakimioun, Amir, Beierlein, Frank, Sellner, Leopold, Schmitt, Michael, Prante, Olaf, Mokhir, Andriy

Publikováno v: Bioconjugate Chemistry; Apr2019, Vol. 30 Issue 4, p1077-1086, 10p

Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers.

Autor: Xu HG; Organic Chemistry Chair II, Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058 Erlangen, Germany., Reshetnikov V; Organic Chemistry Chair II, Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058 Erlangen, Germany., Wondrak M; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany., Eckhardt L; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany., Kunz-Schughart LA; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.; National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany., Janko C; Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Universitätsklinikum Erlangen, 91054 Erlangen, Germany., Tietze R; Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Universitätsklinikum Erlangen, 91054 Erlangen, Germany., Alexiou C; Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Universitätsklinikum Erlangen, 91054 Erlangen, Germany., Borchardt H; Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Faculty of Medicine, Leipzig University, 04107 Leipzig, Germany., Aigner A; Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Faculty of Medicine, Leipzig University, 04107 Leipzig, Germany., Gong W; Department of Medicine V, Heidelberg University Hospital, 69120 Heidelberg, Germany.; Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215006, China., Schmitt M; Department of Medicine V, Heidelberg University Hospital, 69120 Heidelberg, Germany., Sellner L; Department of Medicine V, Heidelberg University Hospital, 69120 Heidelberg, Germany.; Takeda Pharmaceuticals, Cambridge, MA 02139, USA., Daum S; Organic Chemistry Chair II, Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058 Erlangen, Germany.; Merck, Im Laternenacker 5, 8200 Schaffhausen, Switzerland., Özkan HG; Organic Chemistry Chair II, Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058 Erlangen, Germany., Mokhir A; Organic Chemistry Chair II, Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058 Erlangen, Germany.

Publikováno v: Cancers [Cancers (Basel)] 2021 Dec 31; Vol. 14 (1). Date of Electronic Publication: 2021 Dec 31.