Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Özdemirhan Serçin"'
Autor:
Salvatore Benfatto, Özdemirhan Serçin, Francesca R. Dejure, Amir Abdollahi, Frank T. Zenke, Balca R. Mardin
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-22 (2021)
Abstract Background Synthetic lethality describes a genetic interaction between two perturbations, leading to cell death, whereas neither event alone has a significant effect on cell viability. This concept can be exploited to specifically target tum
Externí odkaz:
https://doaj.org/article/ff8c47867c32418e8423c70dbf2b4ab1
Autor:
Paris Roidos, Stephanie Sungalee, Salvatore Benfatto, Özdemirhan Serçin, Adrian M. Stütz, Amir Abdollahi, Jan Mauer, Frank T. Zenke, Jan O. Korbel, Balca R. Mardin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Cells employ different repair pathways to repair DNA double strand breaks. Here, the authors develop a CRISPR/Cas9-dependent method to study choices in DNA repair called the Color Assay Tracing-Repair (CAT-R) which simultaneously measure outcomes of
Externí odkaz:
https://doaj.org/article/229117b82514431a854b76cda0b7c54e
Autor:
Özdemirhan Serçin, Sabine Reither, Paris Roidos, Nadja Ballin, Spyridon Palikyras, Anna Baginska, Katrin Rein, Maria Llamazares, Aliaksandr Halavatyi, Hauke Winter, Thomas Muley, Renata Z Jurkowska, Amir Abdollahi, Frank T Zenke, Beate Neumann, Balca R Mardin
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 6, Pp n/a-n/a (2020)
Externí odkaz:
https://doaj.org/article/794bf89ed59d4f77b1ffbbe5e6ffea7e
Autor:
Alexandros P. Drainas, Ruxandra A. Lambuta, Irina Ivanova, Özdemirhan Serçin, Ioannis Sarropoulos, Mike L. Smith, Theocharis Efthymiopoulos, Benjamin Raeder, Adrian M. Stütz, Sebastian M. Waszak, Balca R. Mardin, Jan O. Korbel
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: TP53 deficiency is the most common alteration in cancer; however, this alone is typically insufficient to drive tumorigenesis. To identify genes promoting tumorigenesis in combination with TP53 deficiency, we perform genome-wide CRISPR-Cas9
Externí odkaz:
https://doaj.org/article/b32ada33421547e3bbddbb495b192552
Autor:
Özdemirhan Serçin, Sabine Reither, Paris Roidos, Nadja Ballin, Spyridon Palikyras, Anna Baginska, Katrin Rein, Maria Llamazares, Aliaksandr Halavatyi, Hauke Winter, Thomas Muley, Renata Z Jurkowska, Amir Abdollahi, Frank T Zenke, Beate Neumann, Balca R Mardin
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 12, Pp n/a-n/a (2019)
Abstract Arrayed CRISPR‐based screens emerge as a powerful alternative to pooled screens making it possible to investigate a wide range of cellular phenotypes that are typically not amenable to pooled screens. Here, we describe a solid‐phase tran
Externí odkaz:
https://doaj.org/article/6ccf8258efa147ae81dc59c197e3f2c6
Autor:
Uwe Schwartz, Maria Llamazares Prada, Stephanie T Pohl, Mandy Richter, Raluca Tamas, Michael Schuler, Corinna Keller, Vedrana Mijosek, Thomas Muley, Marc A Schneider, Karsten Quast, Joschka Hey, Claus P Heußel, Arne Warth, Hauke Winter, Özdemirhan Serçin, Harry Karmouty‐Quintana, Soma SK Jyothula, Manish K Patel, Felix Herth, Ina Koch, Giuseppe Petrosino, Alexandru Titimeaua, Balca R Mardin, Dieter Weichenhan, Tomasz P Jurkowski, Charles D Imbusch, Benedikt Brors, Vladimir Benes, Birgit Jung, David Wyatt, Heiko F Stahl, Christoph Plass, Renata Z Jurkowska
Publikováno v:
The EMBO Journal.
Autor:
Uwe Schwartz, Maria Llamazares Prada, Stephanie T. Pohl, Mandy Richter, Raluca Tamas, Michael Schuler, Corinna Keller, Vedrana Mijosek, Thomas Muley, Marc A. Schneider, Karsten Quast, Joschka Hey, Claus P. Heußel, Arne Warth, Hauke Winter, Özdemirhan Serçin, Harry Karmouty-Quintana, Felix Herth, Ina Koch, Giuseppe Petrosino, Balca R. Mardin, Dieter Weichenhan, Tomasz P. Jurkowski, Charles D. Imbusch, Benedikt Brors, Vladimir Benes, Brigit Jung, David Wyatt, Heiko Stahl, Christoph Plass, Renata Z. Jurkowska
Patients with chronic obstructive pulmonary disease (COPD) are still waiting for curative treatments. Considering the environmental cause of COPD (e.g., cigarette smoke) and disease phenotypes, including stem-cell senescence and impaired differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85bd90abe91fb9904d07649ca3115e87
https://doi.org/10.1101/2022.03.28.486023
https://doi.org/10.1101/2022.03.28.486023
Autor:
Renata Z. Jurkowska, Aliaksandr Halavatyi, Paris Roidos, Amir Abdollahi, Sabine Reither, Nadja Ballin, Özdemirhan Serçin, Frank Zenke, Thomas Muley, Spyridon Palikyras, Maria Llamazares, Hauke Winter, Katrin Rein, Anna Baginska, Balca R. Mardin, Beate Neumann
Publikováno v:
Mol Syst Biol
Molecular Systems Biology, Vol 16, Iss 6, Pp n/a-n/a (2020)
Molecular Systems Biology, Vol 15, Iss 12, Pp n/a-n/a (2019)
Molecular Systems Biology
Molecular Systems Biology, Vol 16, Iss 6, Pp n/a-n/a (2020)
Molecular Systems Biology, Vol 15, Iss 12, Pp n/a-n/a (2019)
Molecular Systems Biology
Arrayed CRISPR‐based screens emerge as a powerful alternative to pooled screens making it possible to investigate a wide range of cellular phenotypes that are typically not amenable to pooled screens. Here, we describe a solid‐phase transfection
Autor:
Özdemirhan Serçin, Michael G. Kemp
Publikováno v:
Cell Cycle. 10:1599-1606
Claspin is a mediator of the ATR-dependent DNA replication checkpoint in human cells and also promotes DNA replication fork progression and stability. Though Claspin has been shown to bind DNA and co-immunoprecipitate with other replication fork-asso
Autor:
Andrea E. Karambelas, Véronique Marthiens, Virginie Moers, Özdemirhan Serçin, Marie Le Mercier, Bram Boeckx, Jean-Christophe Larsimont, Renata Basto, Diether Lambrechts, Cédric Blanpain
Publikováno v:
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2016, 18 (1), pp.100-110. ⟨10.1038/ncb3270⟩
Nature Cell Biology, Nature Publishing Group, 2016, 18 (1), pp.100-110. ⟨10.1038/ncb3270⟩
Aneuploidy is found in most solid tumours, but it remains unclear whether it is the cause or the consequence of tumorigenesis. Using Plk4 overexpression (PLK4OE) during epidermal development, we assess the impact of centrosome amplification and aneup