Výsledky vyhledávání - "Örn Almarsson"

Akademický článek

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

Autor: Siddharth Patel, N. Ashwanikumar, Ema Robinson, Yan Xia, Cosmin Mihai, Joseph P. Griffith, Shangguo Hou, Adam A. Esposito, Tatiana Ketova, Kevin Welsher, John L. Joyal, Örn Almarsson, Gaurav Sahay

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Endosomal sequestration of lipid-based nanoparticles is a barrier to delivery of nucleic acids. Here the authors test an array of cholesterol variants and perform in-depth investigation of nanoparticle shape, internal structure and intracellular traf

Externí odkaz: https://doaj.org/article/9657095ce49a4c28856fa65a8bc45d65

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Akademický článek

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

Autor: Kimberly J. Hassett, Kerry E. Benenato, Eric Jacquinet, Aisha Lee, Angela Woods, Olga Yuzhakov, Sunny Himansu, Jessica Deterling, Benjamin M. Geilich, Tatiana Ketova, Cosmin Mihai, Andy Lynn, Iain McFadyen, Melissa J. Moore, Joseph J. Senn, Matthew G. Stanton, Örn Almarsson, Giuseppe Ciaramella, Luis A. Brito

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 15, Iss , Pp 1-11 (2019)

mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and well-tolerated delivery technology is integral to fully realizing the potential of mRNA vaccines.

Externí odkaz: https://doaj.org/article/a67efab35a6f4ecb83f57432db8444c0

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Akademický článek

Author Correction: Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://doaj.org/article/128cc779536244378fda8c2ba44fd836

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Crystal Chemist, Crooner, Coach: A Transform Tribute to Professor Roger J. Davey

Autor: Örn Almarsson, Sherry Collier, Matthew L. Peterson, Magali B. Hickey, Eugene Y. Cheung, Mark Oliveira, Renato A. Chiarella, Edwin A. Collier

Publikováno v: Crystal Growth & Design. 22:3575-3578

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1667d6f824edfd841ae46a6d4485798e
https://doi.org/10.1021/acs.cgd.1c01399

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Biodistribution of Lipid 5, mRNA, and Its Translated Protein Following Intravenous Administration of mRNA-Encapsulated Lipid Nanoparticles in Rats

Autor: Lei Ci, Marjie Hard, Hannah Zhang, Srujan Gandham, Serenus Hua, John Wickwire, Tod Wehrman, Richard Slauter, Andrew Auerbach, Matthew Kenney, Greg Mercer, Tracy Hendrick, Örn Almarsson, Eugene Cheung, Douglas Burdette

Publikováno v: Drug Metabolism and Disposition. :DMD-AR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7dd70bfcf868b4c75fc634a8c6aceb3
https://doi.org/10.1124/dmd.122.000980

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Systemic Exposure, Metabolism, and Elimination of [14C]-Labeled Amino Lipid, Lipid 5,After a Single Administration of mRNA Encapsulating Lipid Nanoparticles to Sprague Dawley Rats

Autor: Douglas Burdette, Lei Ci, Barclay Shilliday, Richard Slauter, Andrew Auerbach, Matthew Kenney, Örn Almarsson, Eugene Cheung, Tracy Hendrick

Publikováno v: Drug Metabolism and Disposition. :DMD-AR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be235ffe977a32eb3bda60b40d26182b
https://doi.org/10.1124/dmd.122.001194

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Quinoline Binding Site on Malaria Pigment Crystal: A Rational Pathway for Antimalaria Drug Design

Autor: Leslie Leiserowitz, and Örn Almarsson, Matthew L. Peterson, R. Buller

Publikováno v: Crystal Growth & Design. 2:553-562

Human malaria, one of the most striking, reemerging infectious diseases, is caused by several types of Plasmodium parasites. As the parasite digests hemoglobin in human red blood cells, the heme by...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3fe614d4292f882641717a46dfa7642
https://doi.org/10.1021/cg025550i

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Meropenem Exists in Equilibrium with a Carbon Dioxide Adduct in Bicarbonate Solution

Autor: Suzanne M. Mayr, Mark A. Petrich, Örn Almarsson, Yunhui Wu, J. Michael Williams, John D. Stong, Michael J. Kaufman

Publikováno v: Journal of Pharmaceutical Sciences. 87:663-666

□ Evidence is provided for the existence of a second discrete chemical form of meropenem at clinically relevant concentrations prepared from the marketed formulation of the drug. Proton and carbon-13 NMR spectra in D 2 O, coupled with tandem mass s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db110ac6fd2acbe0c738f50461185729
https://doi.org/10.1021/js970370u

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The preparation of homogeneous triglycerides of eicosapentaenoic acid and docosahexaenoic acid by lipase

Autor: Birgir Ö. Gudmundsson, Gudmundur G. Haraldsson, Örn Almarsson

Publikováno v: Tetrahedron Letters. 34:5791-5794

A highly efficient synthesis of homogeneous triglycerides of either pure eicosapentaenoic acid, 1, or docosahexaenoic acid, 2, by an immobilized non-regiospecific yeast lipase from Candida antarctica is described. Two methods were used: Interesterifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::340558f9f0c4008251e228c4463be041
https://doi.org/10.1016/s0040-4039(00)73862-7

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