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List of Contributors

Autor: Abu S.I. Ahmed, Piero Anversa, Fnu Apoorva, Christopher K. Arakawa, David J. Baylink, Laila Benameur, Jonathan Bernhard, Mickie Bhatia, Michael Blatchley, Jeffrey T. Borenstein, Nathalie Brandenberg, David T. Breault, Caroline E. Brun, Rebecca L. Carrier, Naniye Malli Cetinbas, Wanqiu Chen, Yu-Hao Cheng, Fabien P. Chevalier, Hans Clevers, Michael J. Conboy, Irina M. Conboy, Joanne C. Conover, Cole A. DeForest, Henry J. Donahue, Nicolas A. Dumont, Kimberly M. Ferlin, Michael W. Findlay, John P. Fisher, Uwe Freudenberg, Makoto Funaki, Sharon Gerecht, Polina Goichberg, Linda G. Griffith, Géraldine Guasch, Joshua Guild, Ting Guo, Geoffrey C. Gurtner, Pamela Habibovic, Amranul Haque, Xi C. He, Victor Hernandez-Gordillo, Toru Hosoda, Jie Huang, Yoshihiro Ito, Paul A. Janmey, Lei Jiang, Peter Anthony Jones, David S. Kaplan, Jeffrey M. Karp, Christina Klecker, Abigail N. Koppes, Arthur Krause, Maria Leena, Annarosa Leri, Shulamit Levenberg, Xiaowei Li, Yingying Li, Yan Li, Linheng Li, Jung Yul Lim, Yijun Liu, Matthias P. Lutolf, Teng Ma, Kay Maeda, Angad Malhotra, Geetha Manivasagam, Hongli Mao, Hai-Quan Mao, Todd C. McDevitt, Mina Mekhail, Tiziano Moccetti, Eike Müller, Lakshmi S. Nair, Mio Nakanishi, Johnathan Ng, Renu Pasricha, John Perry, Tilo Pompe, Murugan Ramalingam, Keerthana Ramasamy, Deepti Rana, Alexander Revzin, Brandon D. Riehl, Jose Roman, Jatin Roper, Dekel Rosenfeld, Marcello Rota, Jeroen Rouwkema, Michael A. Rudnicki, Marc Ruel, Borja Saez, Nobuo Sasaki, Toshiro Sato, David T. Scadden, Sanaya N. Shroff, Ankur Singh, Quinton Smith, Kara Spiller, Erik J. Suuronen, Maryam Tabrizian, Xiaolei Tang, Krysti L. Todd, Ang-Chen Tsai, Clemens van Blitterswijk, Aparna Venkatraman, Ajaykumar Vishwakarma, Gordana Vunjak-Novakovic, Jane Wang, Shutao Wang, Samiksha Wasnik, Carsten Werner, Jenna L. Wilson, Ömer H. Yılmaz, Xuegang Yuan, Rushdia Z. Yusuf, Xiao-Bing Zhang, Meng Zhao

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fef9dce4b5f201dc72eaa954fe783817
https://doi.org/10.1016/b978-0-12-802734-9.01002-7

Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

Autor: Yi Wen Kong, Erik C. Dreaden, Sandra Morandell, Wen Zhou, Sanjeev S. Dhara, Ganapathy Sriram, Fred C. Lam, Jesse C. Patterson, Mohiuddin Quadir, Anh Dinh, Kevin E. Shopsowitz, Shohreh Varmeh, Ömer H. Yilmaz, Stephen J. Lippard, H. Christian Reinhardt, Michael T. Hemann, Paula T. Hammond, Michael B. Yaffe

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents. Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity t

Externí odkaz: https://doaj.org/article/968af14e7f93410d8098ad17f0bc993d

Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction

Autor: Nadja Gebert, Chia-Wei Cheng, Joanna M. Kirkpatrick, Domenico Di Fraia, Jina Yun, Patrick Schädel, Simona Pace, George B. Garside, Oliver Werz, K. Lenhard Rudolph, Henri Jasper, Ömer H. Yilmaz, Alessandro Ori

Publikováno v: Cell Reports, Vol 31, Iss 4, Pp - (2020)

Summary: The small intestine is responsible for nutrient absorption and one of the most important interfaces between the environment and the body. During aging, changes of the epithelium lead to food malabsorption and reduced barrier function, thus i

Externí odkaz: https://doaj.org/article/6ec250b7c1924a2c8eabf6e16788b454

PKM2 is not required for colon cancer initiated by APC loss

Autor: Allison N. Lau, William J. Israelsen, Jatin Roper, Mark J. Sinnamon, Larissa Georgeon, Talya L. Dayton, Alissandra L. Hillis, Omer H. Yilmaz, Dolores Di Vizio, Kenneth E. Hung, Matthew G. Vander Heiden

Publikováno v: Cancer & Metabolism, Vol 5, Iss 1, Pp 1-7 (2017)

Abstract Background Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential i

Externí odkaz: https://doaj.org/article/3bf4659aa6f34c888e367c4a1462dc96