Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Óttar, Rolfsson"'
Autor:
Pär I. Johansson, Hanne H. Henriksen, Sigurður T. Karvelsson, Óttar Rolfsson, Martin Schønemann-Lund, Morten H. Bestle, Sarah McGarrity
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-14 (2024)
Abstract Sepsis is a major cause of death worldwide, with a mortality rate that has remained stubbornly high. The current gold standard of risk stratifying sepsis patients provides limited mechanistic insight for therapeutic targeting. An improved ab
Externí odkaz:
https://doaj.org/article/738699080381430d9b45ae0de27a6d7f
Autor:
Freyr Jóhannsson, James T. Yurkovich, Steinn Guðmundsson, Ólafur E. Sigurjónsson, Óttar Rolfsson
Publikováno v:
Metabolites, Vol 14, Iss 2, p 91 (2024)
Temperature plays a fundamental role in biology, influencing cellular function, chemical reaction rates, molecular structures, and interactions. While the temperature dependence of many biochemical reactions is well defined in vitro, the effect of te
Externí odkaz:
https://doaj.org/article/9bfd54caf5d64a4fa3f6fc37421be371
Autor:
Aristotelis Kotronoulas, Adrián López García de Lomana, Helga Kristín Einarsdóttir, Hilmar Kjartansson, Randolph Stone, Óttar Rolfsson
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2076 (2023)
Burn wound healing is a complex process orchestrated through successive biochemical events that span from weeks to months depending on the depth of the wound. Here, we report an untargeted metabolomics discovery approach to capture metabolic changes
Externí odkaz:
https://doaj.org/article/04c745511c3c40fbaafbe03fe346c4c7
Autor:
Lea F. Buchweitz, James T. Yurkovich, Christoph Blessing, Veronika Kohler, Fabian Schwarzkopf, Zachary A. King, Laurence Yang, Freyr Jóhannsson, Ólafur E. Sigurjónsson, Óttar Rolfsson, Julian Heinrich, Andreas Dräger
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background New technologies have given rise to an abundance of -omics data, particularly metabolomic data. The scale of these data introduces new challenges for the interpretation and extraction of knowledge, requiring the development of inn
Externí odkaz:
https://doaj.org/article/d6b35fc262944f6188fb91f69512f3df
Autor:
Hanne H. Henriksen, Igor Marín de Mas, Lars K. Nielsen, Joseph Krocker, Jakob Stensballe, Sigurður T. Karvelsson, Niels H. Secher, Óttar Rolfsson, Charles E. Wade, Pär I. Johansson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2257 (2023)
In trauma patients, shock-induced endotheliopathy (SHINE) is associated with a poor prognosis. We have previously identified four metabolic phenotypes in a small cohort of trauma patients (N = 20) and displayed the intracellular metabolic profile of
Externí odkaz:
https://doaj.org/article/f54990fe50e240ebb44f0d7a0ed15e8c
Autor:
Thora Bjorg Sigmarsdottir, Sarah McGarrity, James T. Yurkovich, Óttar Rolfsson, Ólafur Eysteinn Sigurjónsson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Since their initial discovery in 1976, mesenchymal stem cells (MSCs) have been gathering interest as a possible tool to further the development and enhancement of various therapeutics within regenerative medicine. However, our current understanding o
Externí odkaz:
https://doaj.org/article/4719f0f069084b17be3552aa30376edd
Autor:
Joseph D. Krocker, Kyung Hyun Lee, Hanne H. Henriksen, Yao-Wei Willa Wang, Erwin M. Schoof, Sigurdur T. Karvelsson, Óttar Rolfsson, Pär I. Johansson, Claudia Pedroza, Charles E. Wade
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6213 (2022)
Background: The endotheliopathy of trauma (EoT) is associated with increased mortality following injury. Herein, we describe the plasma proteome related to EoT in order to provide insight into the role of the endothelium within the systemic response
Externí odkaz:
https://doaj.org/article/35a2115bcb4649e6a2bad66d2e89e3c6
Autor:
Adrián López García de Lomana, Arnar Ingi Vilhjálmsson, Sarah McGarrity, Rósa Sigurðardóttir, Ósk Anuforo, Alexía Rós Viktorsdóttir, Aris Kotronoulas, Andreas Bergmann, Leifur Franzson, Haraldur Halldórsson, Hanne H. Henriksen, Charles E. Wade, Pär Ingemar Johansson, Óttar Rolfsson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3162 (2022)
Disruption to endothelial cell homeostasis results in an extensive variety of human pathologies that are particularly relevant to major trauma. Circulating catecholamines, such as adrenaline and noradrenaline, activate endothelial adrenergic receptor
Externí odkaz:
https://doaj.org/article/cab676367f2749a5891e196438cbe300
Autor:
Þóra Sigmarsdóttir, Sarah McGarrity, Óttar Rolfsson, James T. Yurkovich, Ólafur E. Sigurjónsson
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the cor
Externí odkaz:
https://doaj.org/article/d108fcfe66af439fb9cad54dfeafff3b
Autor:
Sarah McGarrity, Ósk Anuforo, Haraldur Halldórsson, Andreas Bergmann, Skarphéðinn Halldórsson, Sirus Palsson, Hanne H. Henriksen, Pär Ingemar Johansson, Óttar Rolfsson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Endothelial dysfunction contributes to sepsis outcome. Metabolic phenotypes associated with endothelial dysfunction are not well characterised in part due to difficulties in assessing endothelial metabolism in situ. Here, we describe the con
Externí odkaz:
https://doaj.org/article/3346a06d5da14fb4a956f403770503f3