Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Óscar Fernández-Capetillo"'
Autor:
Sina Atashpaz, Sara Samadi Shams, Javier Martin Gonzalez, Endre Sebestyén, Negar Arghavanifard, Andrea Gnocchi, Eliene Albers, Simone Minardi, Giovanni Faga, Paolo Soffientini, Elisa Allievi, Valeria Cancila, Angela Bachi, Óscar Fernández-Capetillo, Claudio Tripodo, Francesco Ferrari, Andrés Joaquin López-Contreras, Vincenzo Costanzo
Publikováno v:
eLife, Vol 9 (2020)
Unrepaired DNA damage during embryonic development can be potentially inherited by a large population of cells. However, the quality control mechanisms that minimize the contribution of damaged cells to developing embryos remain poorly understood. He
Externí odkaz:
https://doaj.org/article/91525f93557a4ea295fba0e2fcd0a4fa
Publikováno v:
Biology Open, Vol 2, Iss 12, Pp 1402-1411 (2013)
Summary Asynchronous replication of the genome has been associated with different rates of point mutation and copy number variation (CNV) in human populations. Here, our aim was to investigate whether the bias in the generation of CNV that is associa
Externí odkaz:
https://doaj.org/article/9748bff1a2844e6a92d43df4f826d3c8
Publikováno v:
Biology Open, Vol 3, Iss 3, Pp 231-231 (2014)
Externí odkaz:
https://doaj.org/article/099186d9307e4ebcb0abdea3ce00042e
Autor:
Matilde Murga, Gema Lopez-Pernas, Robert Soliva, Elena Fueyo-Marcos, Corina Amor, Ignacio Faustino, Marina Serna, Alicia G. Serrano, Lucía Díaz, Sonia Martínez, Carmen Blanco-Aparicio, Marta Elena Antón, Brinton Seashore-Ludlow, Joaquín Pastor, Rozbeh Jafari, Miguel Lafarga, Oscar Llorca, Modesto Orozco, Oscar Fernández-Capetillo
Publikováno v:
Cell Death and Disease, Vol 15, Iss 9, Pp 1-11 (2024)
Abstract SETD8 is a methyltransferase that is overexpressed in several cancers, which monomethylates H4K20 as well as other non-histone targets such as PCNA or p53. We here report novel SETD8 inhibitors, which were discovered while trying to identify
Externí odkaz:
https://doaj.org/article/954f96d3983d491f8d462549b44cbd7d
Autor:
Cristina Sayago, Jana Sánchez-Wandelmer, Fernando García, Begoña Hurtado, Vanesa Lafarga, Patricia Prieto, Eduardo Zarzuela, Pilar Ximénez-Embún, Sagrario Ortega, Diego Megías, Oscar Fernández-Capetillo, Marcos Malumbres, Javier Munoz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Protein methylation is an important modification beyond epigenetics. However, systems analyses of protein methylation lag behind compared to other modifications. Recently, thermal stability analyses have been developed which provide a proxy
Externí odkaz:
https://doaj.org/article/7354965a01904389904458d4abac3798
Publikováno v:
Molecular Oncology, Vol 16, Iss 21, Pp 3757-3760 (2022)
Externí odkaz:
https://doaj.org/article/d770dcdcce6549449dc1c7195a1f3faf
Autor:
Valeria Colicchia, Maria Häggblad, Oleksandra Sirozh, Bartlomiej Porebski, Mirela Balan, Xuexin Li, Louise Lidemalm, Jordi Carreras‐Puigvert, Daniela Hühn, Oscar Fernandez‐Capetillo
Publikováno v:
FEBS Open Bio, Vol 12, Iss 10, Pp 1896-1908 (2022)
The tetracycline repressor (tetR)‐regulated system is a widely used tool to specifically control gene expression in mammalian cells. Based on this system, we generated a human osteosarcoma cell line, which allows for the inducible expression of an
Externí odkaz:
https://doaj.org/article/ec127910a33a46728af06e40f73ca107
Autor:
Laura Sanchez‐Burgos, Belén Navarro‐González, Santiago García‐Martín, Oleksandra Sirozh, Jorge Mota‐Pino, Elena Fueyo‐Marcos, Héctor Tejero, Marta Elena Antón, Matilde Murga, Fátima Al‐Shahrour, Oscar Fernandez‐Capetillo
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 9, Pp 1-18 (2022)
Abstract FBXW7 is one of the most frequently mutated tumor suppressors, deficiency of which has been associated with resistance to some anticancer therapies. Through bioinformatics and genome‐wide CRISPR screens, we here reveal that FBXW7 deficienc
Externí odkaz:
https://doaj.org/article/256932fb4a3044ed836a66ac7c89974f
Autor:
Daniela Hühn, Pablo Martí‐Rodrigo, Silvana Mouron, Catherine Hansel, Kirsten Tschapalda, Bartlomiej Porebski, Maria Häggblad, Louise Lidemalm, Miguel Quintela‐Fandino, Jordi Carreras‐Puigvert, Oscar Fernandez‐Capetillo
Publikováno v:
Molecular Oncology, Vol 16, Iss 1, Pp 148-165 (2022)
Among others, expression levels of programmed cell death 1 ligand 1 (PD‐L1) have been explored as biomarkers of the response to immune checkpoint inhibitors in cancer therapy. Here, we present the results of a chemical screen that interrogated how
Externí odkaz:
https://doaj.org/article/e389dadc9b3b45f49229c98f0233ae28
Autor:
Leo Hanke, Hrishikesh Das, Daniel J. Sheward, Laura Perez Vidakovics, Egon Urgard, Ainhoa Moliner-Morro, Changil Kim, Vivien Karl, Alec Pankow, Natalie L. Smith, Bartlomiej Porebski, Oscar Fernandez-Capetillo, Erdinc Sezgin, Gabriel K. Pedersen, Jonathan M. Coquet, B. Martin Hällberg, Ben Murrell, Gerald M. McInerney
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Here, the authors isolate and characterize a bispecific monomeric nanobody that induces dimerization of SARS-CoV-2 spike trimers, neutralizes variants of concerns as well as SARS-CoV, and inhibits SARS-CoV-2 infection in mice.
Externí odkaz:
https://doaj.org/article/f14234a7e3914ec1bbba1c457db3bda6