Presence of Extra-Criteria Antiphospholipid Antibodies Is an Independent Risk Factor for Ischemic Stroke

Autor: Laura Naranjo, Fernando Ostos, Francisco Javier Gil-Etayo, Jesús Hernández-Gallego, Óscar Cabrera-Marante, Daniel Enrique Pleguezuelo, Raquel Díaz-Simón, Mercedes Cerro, David Lora, Antonio Martínez-Salio, Antonio Serrano

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Background: Ischemic stroke is the most common and severe arterial thrombotic event in Antiphospholipid syndrome (APS). APS is an autoimmune disease characterized by the presence of thrombosis and antiphospholipid antibodies (aPL), which provide a pr

Externí odkaz: https://doaj.org/article/d1c3e67efcfb4e84880ab119b1283413

Immune dysregulation is an important factor in the underlying complications in Influenza infection. ApoH, IL-8 and IL-15 as markers of prognosis

Autor: Sara Garcinuño, Antonio Lalueza, Francisco Javier Gil-Etayo, Raquel Díaz-Simón, Ignacio Lizasoain, Ana Moraga, Blanca Diaz-Benito, Laura Naranjo, Oscar Cabrera-Marante, Daniel Enrique Pleguezuelo, Maria Ruiz-Ruigomez, Blanca Ayuso, Estibaliz Arrieta, Dolores Folgueira, Estela Paz-Artal, Cecilia Cueto, Carlos Lumbreras, Antonio Serrano, Manuel Serrano

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionInfluenza virus infection can cause a range of clinical symptoms, including respiratory failure (RF) and even death. The mechanisms responsible for the most severe forms of the disease are not yet well understood. The objective is to asse

Externí odkaz: https://doaj.org/article/a11bb4784f4e45ccaa37f9348df97030

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Autor: Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andrés Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaïbi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarström, Nevin Hatipoğlu, Adem Karbuz, Sevgi Keles, Christèle Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarström, Rebeca Pérez de Diego, Laura Planas-Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Rivière, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlüter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M. Alsohime, Hagit Baris-Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, Yu-Lung Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-François Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, COVID Human Genetic Effort, COVIDeF Study Group, French COVID Cohort Study Group, CoV-Contact Cohort, COVID-STORM Clinicians, COVID Clinicians, Orchestra Working Group, Amsterdam UMC Covid-19 Biobank, NIAID-USUHS COVID Study Group, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D. Notarangelo, Stephanie Boisson-Dupuis, Helen C. Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, Aurélie Cobat

Publikováno v: Genome Medicine, Vol 15, Iss 1, Pp 1-25 (2023)

Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening

Externí odkaz: https://doaj.org/article/86e4db2aa39842caa8f2f5c9e6d95290

Case Report: Resetting the Humoral Immune Response by Targeting Plasma Cells With Daratumumab in Anti-Phospholipid Syndrome

Autor: Daniel E. Pleguezuelo, Raquel Díaz-Simón, Oscar Cabrera-Marante, Antonio Lalueza, Estela Paz-Artal, Carlos Lumbreras, Antonio Serrano Hernández

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

IntroductionMonoclonal antibodies (mAb) targeting plasma cells are malignant gammopathy designed and approved therapies. In recent years, these antibodies have also been increasingly introduced for non-malignant conditions such as autoimmune-mediated

Externí odkaz: https://doaj.org/article/b281d642ad8048009561e46d776c0a26

Perforin gene variant A91V in young patients with severe COVID-19

Autor: Oscar Cabrera-Marante, Edgard Rodríguez de Frías, Daniel E. Pleguezuelo, Luis M. Allende, Antonio Serrano, Rocío Laguna-Goya, María Esther Mancebo, Paloma Talayero, Luis Álvarez-Vallina, Pablo Morales, Maria José Castro-Panete, Estela Paz-Artal

Publikováno v: Haematologica, Vol 105, Iss 12 (2020)

Externí odkaz: https://doaj.org/article/dfa0eb2bbf964131975166a0d6e24a05