Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Ícaro P. Caruso"'
1
Akademický článek
Insights into the Substrate Uptake Mechanism of Mycobacterium Tuberculosis Ribose 5-Phosphate Isomerase and Perspectives on Drug Development
Autor: Leonardo Bartkevihi, Ícaro P. Caruso, Bruna Martins, José R. M. Pires, Danielle M. P. Oliveira, Cristiane Dinis Anobom, Fabio C. L. Almeida
Publikováno v: Biophysica, Vol 3, Iss 1, Pp 139-157 (2023)
The active site of the dimeric ribose 5-phosphate isomerase B (RpiB) contains a solvent-exposed barrier formed by residues H12, R113, R137, and R141, which is closed upon the complexation of phosphate. The substrate ribose 5-phosphate (R5P) has to ov
Externí odkaz: https://doaj.org/article/b2d1450f87724db8880684554c44bac8
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2
Akademický článek
Alterations in the Cellular Metabolic Footprint Induced by Mayaro Virus
Autor: Ceyla M. O. Castro, Mânlio T. O. Mota, Alessandra Vidotto, Ícaro P. Caruso, Milene R. Ribeiro, Fábio R. Moraes, Fátima P. Souza, Mauricio L. Nogueira
Publikováno v: BioMed, Vol 3, Iss 1, Pp 152-165 (2023)
Mayaro virus is a neglected virus that causes a mild, dengue-like febrile syndrome characterized by fever, headache, rash, retro-orbital pain, vomiting, diarrhea, articular edemas, myalgia, and severe arthralgia, symptoms which may persist for months
Externí odkaz: https://doaj.org/article/3844749b50a849ae9902b3a5c806c754
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3
Akademický článek
Searching for drug leads targeted to the hydrophobic cleft of dengue virus capsid protein
Autor: Liliane O. Ortlieb, Ícaro P. Caruso, Nathane C. Mebus-Antunes, Andrea T. Da Poian, Elaine da C. Petronilho, José Daniel Figueroa-Villar, Claudia J. Nascimento, Fabio C. L. Almeida
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 287-298 (2022)
We synthesised and screened 18 aromatic derivatives of guanylhydrazones and oximes aromatic for their capacity to bind to dengue virus capsid protein (DENVC). The intended therapeutic target was the hydrophobic cleft of DENVC, which is a region respo
Externí odkaz: https://doaj.org/article/ded108e4fe594222bc011e4fbb359cf6
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4
Akademický článek
Grb2 dimer interacts with Coumarin through SH2 domains: A combined experimental and molecular modeling study
Autor: Karoline Sanches, Raphael Vinicius Rodrigues Dias, Paulo Henrique da Silva, Marcelo Andrés Fossey, Ícaro Putinhon Caruso, Fátima Pereira de Souza, Leandro Cristante de Oliveira, Fernando Alves de Melo
Publikováno v: Heliyon, Vol 5, Iss 11, Pp e02869- (2019)
Grb2 is an important regulator of normal vs. oncogenic cell signaling transduction. It plays a pivotal role on kinase-mediated signaling transduction by linking Receptor Tyrosine kinases to Ras/MAPK pathway which is known to bring oncogenic outcome.
Externí odkaz: https://doaj.org/article/2e8b13c322784fc9aaea4b6a5af4bfb2
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5
Akademický článek
Biophysical and flavonoid-binding studies of the G protein ectodomain of group A human respiratory syncytial virus
Autor: Vitor Brassolatti Machado, Jéssica Maróstica de Sá, Ana Karla Miranda Prado, Karina Alves de Toledo, Luis Octávio Regasini, Fátima Pereira de Souza, Ícaro Putinhon Caruso, Marcelo Andres Fossey
Publikováno v: Heliyon, Vol 5, Iss 3, Pp e01394- (2019)
The human Respiratory Syncytial Virus (hRSV) is the major causative agent of lower respiratory tract diseases in infants, young children and elderly. The membrane protein G is embedded in the viral lipid envelope and plays an adhesion function of the
Externí odkaz: https://doaj.org/article/a8ba523822414a43af9a96595ca1959e
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7
Searching for drug leads targeted to the hydrophobic cleft of dengue virus capsid protein
Autor: Liliane O. Ortlieb, Ícaro P. Caruso, Nathane C. Mebus-Antunes, Andrea T. Da Poian, Elaine da C. Petronilho, José Daniel Figueroa-Villar, Claudia J. Nascimento, Fabio C. L. Almeida
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 287-298 (2022)
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2022-04-29T08:37:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 We synthesised and screened 18 aromatic derivatives of guanylhydrazones and oximes aromatic for their capacity to bind to dengue virus capsid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff60937b38568356ce3cd37d9634e3a0
https://pubmed.ncbi.nlm.nih.gov/34894959
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8
Molecular Docking Studies of Curcumin Analogues against SARS-CoV-2 Spike Protein
Autor: Felipe Garcia Nishimura, Ana Lúcia Fachin, Mozart Marins, Jonathan R. Dimmock, Jéssica R. Nogueira, Umashankar Das, Flávia Alves Verza, Ícaro P. Caruso
Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Journal of the Brazilian Chemical Society v.32 n.10 2021
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 32, Issue: 10, Pages: 1943-1955, Published: 01 OCT 2021
Made available in DSpace on 2022-04-29T08:33:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the etiolog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07115b472d6c7b56de282c032420c7e2
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9
NMR assignment of free
Autor: Karoline, Sanches, Ícaro P, Caruso, Fábio C L, Almeida, Fernando A, Melo
Publikováno v: Biomolecular NMR assignments. 13(2)
Growth factor receptor-bound protein 2 (Grb2) is an adaptor protein composed of three domains, an N-terminal SH3 (nSH3), SH2 and a C-terminal SH3 (cSH3) domains. This multi-domain protein has been reported to be a key factor in many signaling pathway
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56ecc3ee81547bba98c5bfac04c55f4c
https://pubmed.ncbi.nlm.nih.gov/31028611
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10
Binding investigation between M2-1protein from hRSV and acetylated quercetin derivatives
Autor: Giovana C, Guimarães, Hemily R M, Piva, Gabriela C, Araújo, Caroline S, Lima, Luis O, Regasini, Fernando A, de Melo, Marcelo A, Fossey, Ícaro P, Caruso, Fátima P, Souza
Publikováno v: International journal of biological macromolecules. 111
The human Respiratory Syncytial Virus (hRSV) is the main responsible for occurrences of respiratory diseases as pneumonia and bronchiolitis in children and elderly. M2-1 protein from hRSV is an important antitermination factor for transcription proce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e5bd4d954a5390c8a848dc24511c443
https://pubmed.ncbi.nlm.nih.gov/29292149
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