Increased mTOR Signaling and Impaired Autophagic Flux Are Hallmarks of SARS-CoV-2 Infection

Autor: Érika Pereira Zambalde, Thomaz Luscher Dias, Grazielle Celeste Maktura, Mariene R. Amorim, Bianca Brenha, Luana Nunes Santos, Lucas Buscaratti, João Gabriel de Angeli Elston, Mariana Camargo Silva Mancini, Isadora Carolina Betim Pavan, Daniel A. Toledo-Teixeira, Karina Bispo-dos-Santos, Pierina L. Parise, Ana Paula Morelli, Luiz Guilherme Salvino da Silva, Ícaro Maia Santos de Castro, Tatiana D. Saccon, Marcelo A. Mori, Fabiana Granja, Helder I. Nakaya, Jose Luiz Proenca-Modena, Henrique Marques-Souza, Fernando Moreira Simabuco

Publikováno v: Current Issues in Molecular Biology, Vol 45, Iss 1, Pp 327-336 (2022)

The COVID-19 (Coronavirus Disease 2019), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), severely affects mainly individuals with pre-existing comorbidities. Here our aim was to correlate the mTOR (mammalian/mechanistic Ta

Externí odkaz: https://doaj.org/article/100e2fe393e1485f9350e2393da3bc1e

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

Autor: Fernanda Crunfli, Victor C. Carregari, Flavio P. Veras, Lucas S. Silva, Mateus Henrique Nogueira, André Saraiva Leão Marcelo Antunes, Pedro Henrique Vendramini, Aline Gazzola Fragnani Valença, Caroline Brandão-Teles, Giuliana da Silva Zuccoli, Guilherme Reis-de-Oliveira, Lícia C. Silva-Costa, Verônica Monteiro Saia-Cereda, Bradley J. Smith, Ana Campos Codo, Gabriela F de Souza, Stéfanie P. Muraro, Pierina Lorencini Parise, Daniel A. Toledo-Teixeira, Ícaro Maia Santos de Castro, Bruno Marcel Melo, Glaucia M. Almeida, Egidi Mayara Silva Firmino, Isadora Marques Paiva, Bruna Manuella Souza Silva, Rafaela Mano Guimarães, Niele D. Mendes, Raíssa L. Ludwig, Gabriel P. Ruiz, Thiago L. Knittel, Gustavo G. Davanzo, Jaqueline Aline Gerhardt, Patrícia Brito Rodrigues, Julia Forato, Mariene Ribeiro Amorim, Natália S. Brunetti, Matheus Cavalheiro Martini, Maíra Nilson Benatti, Sabrina S. Batah, Li Siyuan, Rafael B. João, Ítalo K. Aventurato, Mariana Rabelo de Brito, Maria J. Mendes, Beatriz A. da Costa, Marina K. M. Alvim, José Roberto da Silva Júnior, Lívia L. Damião, Iêda Maria P. de Sousa, Elessandra D. da Rocha, Solange M. Gonçalves, Luiz H. Lopes da Silva, Vanessa Bettini, Brunno M. Campos, Guilherme Ludwig, Lucas Alves Tavares, Marjorie Cornejo Pontelli, Rosa Maria Mendes Viana, Ronaldo B. Martins, Andre Schwambach Vieira, José Carlos Alves-Filho, Eurico Arruda, Guilherme Gozzoli Podolsky-Gondim, Marcelo Volpon Santos, Luciano Neder, André Damasio, Stevens Rehen, Marco Aurélio Ramirez Vinolo, Carolina Demarchi Munhoz, Paulo Louzada-Junior, Renê Donizeti Oliveira, Fernando Q. Cunha, Helder I. Nakaya, Thais Mauad, Amaro Nunes Duarte-Neto, Luiz Fernando Ferraz da Silva, Marisa Dolhnikoff, Paulo Hilario Nascimento Saldiva, Alessandro S. Farias, Fernando Cendes, Pedro Manoel M. Moraes-Vieira, Alexandre T. Fabro, Adriano Sebollela, José L. Proença-Modena, Clarissa L. Yasuda, Marcelo A. Mori, Thiago M. Cunha, Daniel Martins-de-Souza

Publikováno v: Proceedings of the National Academy of Sciences. 119

Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently characterized as part of “long COVID-19” syndrome) has been frequently observ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47ddeff3c7b9a059a857e00fd4d3c15
https://doi.org/10.1073/pnas.2200960119

Increased mTOR signaling, impaired autophagic flux and cell-to-cell viral transmission are hallmarks of SARS-CoV-2 infection

Autor: Thomaz Luscher Dias, Mariene R. Amorim, Raissa G. Ludwig, Ícaro Maia Santos de Castro, Thiago L. Knittel, Stéfanie Primon Muraro, Luana Nunes Santos, Mariana Camargo Silva Mancini, Bianca de Freitas Brenha, Grazielle C. Maktura, Marcelo A. Mori, Pierina Lorencini Parise, Guilherme Oliveira Barbosa, Daniel A. Toledo-Teixeira, Helder I. Nakaya, Henrique Marques-Souza, Tatiana D. Saccon, Karina Bispo-dos-Santos, José Luiz Proença-Módena, Cynthia Mara, Lucas I. Buscaratti, Erika Pereira Zambalde, Hernandes F. Carvalho, Fernando Moreira Simabuco, Luiz Guilherme Salvino da Silva, Fabiana Granja, Isadora Carolina Betim Pavan, Ana Paula Morelli, Gabriela Fabiano de Souza, Luis Lamberti Pinto da Silva, Joao Gabriel de Angeli Elston

The COVID-19 disease caued by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has two characteristics that distinguish it from other viral infections. It affects more severely people with pre-existing comorbidities and viral load pea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ce9ef80acdf7b2c73920914b5445ef8
https://doi.org/10.1101/2021.10.13.464225

Sepsis expands a CD39 + plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity

Autor: Paulo Henrique Melo, Luisa Menezes-Silva, Fernando Q. Cunha, Marcos C. Borges, Bernhard Ryffel, Daniel Zoppi, Ícaro Maia Santos de Castro, Juliana E Toller-Kawahisa, Diego B. Caetite, Paula Ramos Viacava, Antonio Edson Rocha Oliveira, Raphael S. Peres, Helder I. Nakaya, Daniele C. Nascimento, Joel Linden, Thiago M. Cunha, Dario S. Zamboni, Gilles Kauffenstein, José C. Alves-Filho, Raphael Gomes Ferreira, Valérie F. J. Quesniaux, Denise Morais da Fonseca, Flávio P. Veras, Paula B. Donate, Annie R. Piñeros, Jonas Augusto Rizzato Paschoal, Marina Alves Damaceno

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Immunity
Immunity, Elsevier, 2021, 54 (9), pp.2024-2041.e8. ⟨10.1016/j.immuni.2021.08.005⟩

Sepsis results in elevated adenosine in circulation. Extracellular adenosine triggers immunosuppressive signaling via the A2a receptor (A2aR). Sepsis survivors develop persistent immunosuppression with increased risk of recurrent infections. We utili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478195521c4469e00f8cd9a0d748fe20

The Potential Effect of Oral Bacterial Community in Melanophryniscus Admirabilis (Admirable Red-Belly Toads) Conservation

Autor: Janira Prischula, Ana Paula Guedes Frazzon, Valentina Caorsi, Márcio Borges-Martins, Juliana Mello Severo, Jeverson Frazzon, Ícaro Maia Santos de Castro, Thayná Mendes De Freitas Lima, Michelle Abadie, Michele Bertoni Mann

Melanophryniscus admirabilis (admirable red-belly toad) is a microendemic and critically endangered species found exclusively along 700 meters of the Forqueta River, in a fragment of Atlantic Forest in southern Brazil. One of the greatest concerns re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392b342486bb2433fa21b42f9e35fc26